Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Principal Engineer - Product Testing
$121K - $205K *
Lead the charge in optimizing pressure decay leak test systems across manufacturing lines. As a subject matter expert, you'll ensure compliance and reliability in testing processes, driving continuous...
1 week ago
$80K - $90K *
Empower the future of fusion energy by maintaining and enhancing complex electrical systems in a cutting-edge research environment. Collaborate with multidisciplinary teams to drive innovation and ens...
1 week ago
Lead Principal Technical Program Manager
$116K - $264K *
Shape the future of technical programs by leading cross-functional initiatives, managing risks, and optimizing processes to drive transformational change and enhance organizational efficiency across m...
Today
Lead Principal Technical Program Manager
$116K - $264K *
Lead the charge in integrated technical execution across scientific computing, laboratory automation, and AI workflows. Drive complex programs, resolve dependencies, and ensure successful delivery fro...
2 days ago
Lead Principal Technical Program Manager
$116K - $264K *
Drive integrated technical execution across scientific computing and laboratory automation. Lead complex programs, manage dependencies, and ensure successful delivery from planning to production readi...
2 days ago
Lead Principal Technical Program Manager
$116K - $264K *
Transform integrated technical execution across scientific computing and laboratory automation. Lead complex programs, resolve dependencies, and drive delivery from planning to production readiness wh...
2 days ago
Lead Principal Technical Program Manager
$116K - $264K *
Lead complex, high-impact technical programs by aligning cross-functional teams and driving strategic execution. Manage risks and dependencies while ensuring successful delivery and continuous improve...
4 days ago
Lead Principal Technical Program Manager
$116K - $264K *
Drive large-scale infrastructure initiatives as a Senior Principal Technical Program Manager, coordinating complex programs across engineering and operations to support rapid global expansion and enha...
2 weeks ago
Scientist I/II, Adsorbent Chemistry
$100K - $125K *
Transform the future of adsorbent materials by developing in-house resin synthesis and characterization methods. Collaborate with cross-functional teams to enhance process performance and drive innova...
2 weeks ago
$65K - $120K *
Join a team that's pioneering research at the intersection of geriatrics, dementia, and emergency care. Lead innovative projects, manage data analysis, and collaborate with diverse stakeholders to enh...
2 weeks ago
$120K - $140K *
Lead the charge in advancing quantitative research on substance use and mental health. Collaborate with diverse partners to enhance treatment quality and health outcomes for vulnerable populations thr...
2 weeks ago
$85K - $100K *
Lead innovative research in statistical genetics, driving advancements in complex traits and disease prediction. Collaborate with a dynamic team to analyze large datasets and mentor emerging scientist...
2 weeks ago
Medicinal Chemistry Senior Principal Research Scientist
$164K - $246K *
Champion innovative medicinal chemistry solutions driving small-molecule drug discovery. Lead multidisciplinary teams to optimize drug candidates, mentor talent, and advance research goals through str...
Reposted 2 weeks ago
$101K - $152K *
Lead the charge in advancing high-energy diagnostics through innovative design and operational excellence. Collaborate with top-tier facilities to enhance experimental capabilities and ensure precisio...
3 days ago
Senior Scientist - Project Manager - Stormwater Compliance
$90K - $140K *
Unlock your potential by leading stormwater compliance projects, providing technical expertise, and mentoring junior staff. Collaborate with clients and regulatory agencies to ensure effective environ...
2 days ago
Senior Scientist - Project Manager - Stormwater Compliance
$90K - $140K *
Accelerate progress at stormwater compliance projects, providing technical leadership, project management, and regulatory guidance. Mentor junior staff and ensure high-quality deliverables while manag...
Reposted 5 days ago
Scientist/Senior Scientist In Vitro Biology
$110K - $130K *
Drive high-throughput screening initiatives to evaluate siRNA efficacy in mammalian cells. Lead a team in developing automated processes and assays, collaborating across projects to enhance drug devel...
1 week ago
$123K - $197K *
Transform the landscape of AI by architecting and optimizing cutting-edge LLMs while collaborating with diverse tech teams to innovate and enhance applications for performance and accuracy in resource...
Reposted 4 weeks ago
Director, Scientific Capability Engineering
$150K - $180K *
Lead the strategic direction and operational management of scientific tools and APIs, driving capability enablement across multiple scientific domains while fostering a culture of excellence and innov...
2 weeks ago
Chemical Development, Senior Scientist II
$95K - $115K *
Elevate the development of innovative chemical processes by optimizing existing routes and synthesizing key intermediates. Collaborate with teams to ensure project success while maintaining safety and...
3 weeks ago
Senior Director, Product Management
$169K - $355K *
Pioneer innovative product strategies by leading market analysis and aligning teams to customer needs. Drive product lifecycle management and foster collaboration across business units to enhance cust...
3 days ago
Senior Director, Product Management
$169K - $355K *
Elevate product strategy by leading market research and analysis teams, aligning product portfolios with strategic goals, and driving innovation through customer insights and data-driven decision-maki...
3 days ago
Senior Director, Product Management
$165K - $355K *
Drive strategic leadership and execution for managing complex customer demand at scale. Lead a high-performing team, establish governance frameworks, and influence cross-organizational decisions to al...
1 month ago
Project Manager, Technical Operations
$95K - $115K *
Lead the charge in managing cross-functional projects with CMOs and suppliers, ensuring compliance and timely execution of manufacturing programs. Collaborate with stakeholders to drive project succes...
1 week ago
$120K - $145K *
Drive innovation and efficiency in extrusion technology by leading process development, scale-up, and commercialization efforts. Collaborate cross-functionally to ensure robust manufacturing processes...
2 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.