High-Paying Principal Scientist Jobs

At Ladders, we host a range of top-tier Principal Scientist jobs from verified employers, all with salaries over $100,000. As a Principal Scientist, your role combines leadership skills with deep scientific expertise. Our platform allows you to explore, apply, and rise in your career.

Why Choose Ladders?

At Ladders, we pride ourselves on hosting only verified jobs from accredited employers, ensuring that you focus on opportunities that match your skills and pay scale expectations. Start your journey towards becoming a high-earning Principal Scientist today!

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$143K - $299K *

The Senior Research Scientist will develop and apply advanced machine learning and deep learning models to enhance personalization and user modeling for Yahoo Mail. This role involves conducting resea...

US-AnywhereRemote

1 month ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $180K *

The Principal Scientist will lead the development of scalable and user-centric machine learning solutions for Infor's AI/ML strategy. This role involves defining the vision for ML engines, translating...

US-AnywhereRemote

2 weeks ago

  •     Information Technology

$130K - $180K *

The Principal Scientist will lead the development of scalable and user-centric machine learning solutions for Infor's AI/ML strategy across various industry-specific domains. This role involves defini...

US-AnywhereRemote

5 days ago

  •     Information Technology

$142K - $179K *

The Senior Scientist / NRDA Lead will manage Stantec's NRDA Program, leading multi-disciplinary projects related to hazardous waste releases or oil spills. The role requires strong communication skill...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$120K - $160K *

The Research Scientist Sr will support the Numerical Weather Prediction (NWP) research and development program by creating software for Navy NWP and Aerosol models. This role involves developing vario...

US-AnywhereRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $120K *

The Research Scientist will contribute to the NRL METOC R&D program by developing software for Navy Numerical Weather Prediction and Aerosol models. Key responsibilities include leading the PyroCb pre...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $120K *

The Scientist, Analytical Sciences / QC will be responsible for the analytical aspects of drug product development and manufacturing activities, ensuring high-quality support for a late-stage small mo...

US-AnywhereRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$65K - $117K *

The Research Scientist position at Leidos involves utilizing AI and machine learning skills to support Cyber AI projects. The role includes designing and implementing AI/ML models, creating prototypes...

US-AnywhereRemote

1 month ago

  •   Less than 5 years exp.  •   Technical Services

$120K - $180K *

Leonardo.Ai is seeking a Senior Research Scientist to lead research in multimodal AI, focusing on image, video, 3D, and language modeling. The role involves architecting, training, and evaluating foun...

US-AnywhereRemote

1 month ago

  •     Information Technology

$120K - $180K *

Leonardo.Ai is seeking a Senior Research Scientist to lead research in multimodal AI, focusing on image, video, 3D, and language modeling. The role involves architecting, training, and evaluating foun...

US-AnywhereRemote

1 month ago

  •     Information Technology

$117K - $194K *

The Senior Research Scientist will lead and oversee major research projects, develop externally funded research programs, and contribute to peer-reviewed publications. This role requires providing men...

US-AnywhereRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$128K - $266K *

The Research Scientist role at Yahoo involves developing and implementing machine learning algorithms to enhance the quality of Yahoo Search products. Candidates will work collaboratively to solve com...

US-AnywhereRemote

1 month ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $240K *

The Senior Scientist in Molecular Design will lead efforts in small molecule design using high-throughput computational tools and vast chemical datasets. This role involves collaboration with chemistr...

US-AnywhereRemote

1 month ago

  •     Pharmaceuticals & Biotech

$70K - $100K *

The R&D Scientist at Alphia is responsible for managing research and development projects related to new product and process development in the pet food industry. This role involves formulating pet fo...

US-AnywhereRemote

1 month ago

  •   5 - 7 years exp.  •   Food & Beverages

$112K - $208K *

Thomson Reuters Labs is seeking a Senior Applied Scientist with expertise in Machine Learning and Natural Language Processing to design and deliver AI solutions that enhance their products. The role i...

US-AnywhereRemote

1 month ago

  •   5 - 7 years exp.  •   Media

$80K - $120K *

The Senior Project Manager, Process Excellence will lead and manage multiple projects focused on utilizing Lean Six Sigma methodologies to enhance workflows and reduce costs within the organization. T...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$66K - $127K *

The Scientist, Quality Systems role at Viatris involves fostering continuous improvements in quality system practices to meet global regulatory requirements. The position requires independent research...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$113K - $170K *

The Staff Program Manager will lead critical initiatives within the software business segment of the Transplant Diagnostics division, focusing on the development of Research Use Only (RUO) and In Vitr...

US-AnywhereRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $169K *

The Senior Global Product Support Scientist at 10X Genomics is responsible for providing advanced product support and serving as a subject matter expert to ensure customer success across various produ...

US-AnywhereRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $169K *

The Senior Global Product Support Scientist at 10X Genomics is responsible for providing advanced product support and serving as a subject matter expert to ensure customer success across various produ...

US-AnywhereRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$171K - $275K *

The Virtual Screening Applications Expert will lead small molecule virtual screening activities at Lilly, collaborating with various teams to enhance drug discovery efforts. This role requires a visio...

US-AnywhereRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$83K - $145K *

Parsons is seeking a Principal Geologist/Engineer to join their team in the Rocky Mountain region, focusing on environmental site characterization, investigation, and remediation. The role involves pe...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Staffing

$120K - $180K *

The ARPA-H Senior Scientist (Chemist) Technical SETA will support the Advanced Research Projects Agency for Health by providing expertise in biomedical research and assisting in the development and ma...

US-AnywhereRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$126K - $173K *

The Lead Research Scientist will spearhead the identification and development of opportunities to enhance healthcare delivery and improve member health outcomes using advanced data science methods. Th...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$126K - $173K *

The Lead Research Scientist will spearhead the identification and development of opportunities to enhance healthcare delivery and improve member health outcomes using advanced data science methods. Th...

US-AnywhereRemote

2 weeks ago

  •   5 - 7 years exp.  •   Staffing

Frequently Asked Questions (FAQ)

  • What does a Principal Scientist do?question toggle

    A Principal Scientist is a senior scientific research role. They lead a team of scientists in research and development efforts, ensuring projects are completed correctly and on time. This includes designing and prepping experiments, analysing data, and presenting findings.

  • What qualifications are required for a Principal Scientist job?question toggle

    The qualifications depend on the field, but typically include a PhD or master’s degree in a relevant scientific discipline, strong research skills, and experience in leading projects or teams of scientists.

  • What salary can a Principal Scientist expect?question toggle

    The compensation for a Principal Scientist role varies based on location, industry, level of experience and size of the company. However, rest assured, all Principal Scientist jobs listed on Ladders pay $100,000 or more.