Welcome to Principal Scientist Jobs

Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.

Why Principal Scientist Jobs?

As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.

Our Offerings

We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.

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$151K - $175K *

Elevate NGS diagnostic innovation by leading algorithm development to enhance clinical outcomes. Drive analytical validation, regulatory readiness, and algorithm performance in oncology, focusing on s...

US-AnywhereRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $125K *

Join a team that's revolutionizing materials innovation by applying computational science and machine learning. Collaborate with cross-functional experts to transform research breakthroughs into scala...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$213K - $355K *

Tackle high-impact research in frontier industrial AI, developing innovative models, algorithms, and evaluation frameworks. Lead initiatives that push the boundaries of technology while collaborating...

US-AnywhereRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $140K *

Join a dynamic team as a Senior Research Scientist, where you will lead innovative projects in evidence synthesis. Collaborate with experts while managing deliverables and mentoring junior researchers...

US-AnywhereRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Join us to elevate quality standards in radiopharmaceutical development. Lead GMP compliance and quality systems while mentoring junior staff. Drive improvement across our portfolio, ensuring regulato...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$275K - $350K *

Join a team that builds integrated nonclinical safety strategies for oligonucleotide therapeutics, guiding studies from candidate selection through clinical development while ensuring scientific rigor...

US-AnywhereRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$167K - $278K *

Elevate your career by shaping AI governance and compliance frameworks that ensure responsible AI deployment while driving measurable business impact in clinical research. Lead a team committed to tra...

US-AnywhereRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead the charge in advancing quality assurance for cutting-edge radiopharmaceuticals. Oversee development quality, regulatory compliance, and team leadership, ensuring alignment with GMP and enhancing...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that’s dedicated to enhancing national bathymetric models. Engage in data processing and validation, optimizing workflows, and contributing to improved marine navigation and hydrodynamic m...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$145K - $180K *

Champion innovative AI-driven solutions as you lead cross-functional teams to design, optimize, and deploy impactful biologic products. Play a vital role in bridging AI research and product developmen...

US-AnywhereRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$225K - $250K *

Transform your career by leading a high-performing Epidemiology team to deliver scientifically rigorous projects. Manage cross-functional collaborations and strategic initiatives to enhance client out...

US-AnywhereRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$200K - $300K *

Shape the future of embodied intelligence by leading groundbreaking research in Vision AI and multimodal foundation models. Collaborate with a dynamic team to create innovative solutions that advance...

US-AnywhereRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$175K - $210K *

Pioneer advancements in oncology by leading global product development for late-stage radiopharmaceuticals. Collaborate across functions to meet objectives, manage risks, and ensure regulatory complia...

US-AnywhereRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $190K *

Shape the future of AI alignment research by owning and accelerating innovative projects. Collaborate with engineers and scientists, publish findings, and engage with the AI community while developing...

US-AnywhereRemote

3 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$100K - $120K *

Elevate clinical research by assisting with study design, medical monitoring, and compliance to ensure effective execution of clinical trials and contribute positively to patient outcomes in alignment...

US-AnywhereRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Shape health technology assessments as a Senior Research Scientist. Collaborate on cutting-edge projects, mentor junior researchers, and manage client interactions to deliver impactful evidence synthe...

US-AnywhereRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$165K - $290K *

Unlock potential by leading real-world evidence strategies for Cardiometabolic Health. Drive innovative data solutions, oversee impactful research initiatives, and collaborate cross-functionally to en...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Manage and lead a team of Medical Scientists, ensuring compliance and support for clinical studies while driving medical innovation and operational excellence in life-saving projects...

US-AnywhereRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $146K *

Join a team that's dedicated to optimizing bioprocess technologies. Leverage your expertise in cell culture and bioprocessing to deliver technical support and solutions for customers, enhancing their...

US-AnywhereRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$153K - $290K *

Champion scientific excellence by providing leadership in toxicology and nonclinical safety strategies across drug discovery and development, focusing on small-molecule therapeutics and ensuring progr...

US-AnywhereRemote

3 days ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$125K - $157K *

Lead the transformation of R&D through digital innovation, managing product roadmaps, coordinating diverse teams, and ensuring user-centric software solutions deliver real business value and foster sc...

US-AnywhereRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$177K - $338K *

Champion DMPK project leadership by ensuring high-quality data delivery and supporting drug candidate progression through innovative modeling and cross-functional collaboration in a dynamic biotech en...

US-AnywhereRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$144K - $215K *

Drive cross-functional excellence by leading complex, enterprise-level programs, ensuring alignment with corporate goals while facilitating collaboration among diverse stakeholders for impactful outco...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$167K - $278K *

Drive innovation by scaling AI engineering and platforms, ensuring operational excellence and robust delivery systems that enhance clinical research capabilities and streamline drug development proces...

US-AnywhereRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What is the role of a Principal Scientist?question toggle

    A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.

  • How much does a Principal Scientist earn on average?question toggle

    The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.

  • What qualifications are required for Principal Scientist jobs?question toggle

    Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.

  • Can I find remote Principal Scientist jobs on Ladders?question toggle

    Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.