Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.
As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.
We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.
$126K - $159K *
Drive innovative chemoproteomics workflows, collaborating with cross-functional teams to support drug discovery and platform advancements in a fast-paced research environment, leveraging mass spectrom...
1 week ago
Senior Scientist, Drug Metabolism and Pharmacokinetics
$140K - $222K *
Join a team that's driving innovation in drug development by designing and executing advanced assays to evaluate immunogenicity, while mentoring staff and enhancing R&D initiatives in a collaborative...
Reposted today
Senior Principal Research Scientist
$150K - $200K *
Contribute to scientific excellence by leading advanced research initiatives aimed at integrating emerging technologies, mentoring top talent, and advancing sustainable practices in biomedical researc...
3 weeks ago
Principal Scientist, Global Upstream Production
$120K - $150K *
Lead and empower global production operations through immersive training in China before transitioning to a senior role abroad, shaping future biopharmaceutical leadership with a blend of local insigh...
Reposted 6 days ago
Principal Scientist, Global Upstream Production
$120K - $150K *
Accelerate progress at a global scale by leading upstream production initiatives. Develop talent and optimize processes through deep immersion in local systems for impactful project delivery and cross...
Reposted 5 days ago
Research Scientist, Life Sciences
$300K - $320K *
Explore the intersection of AI and biology, driving advancements in computational biology and empowering scientific workflows through innovative tools and model capabilities that bridge biology and ma...
3 days ago
$99K - $120K *
Reimagine research excellence as a Senior Scientist II, driving projects in PhysChem to advance technologies, support market innovations, and collaborate across teams, while leading junior researchers...
1 week ago
Senior Scientist, Analytical Development and Quality Control (Drug Product)
$161K - $185K *
Grow your career with our team as a Senior Scientist in Analytical Development. Leverage your expertise in drug product analytical methods, supporting regulatory submissions and guiding cross-function...
3 weeks ago
Principal Scientist/ Senior Principal Scientist, Large Molecule Biology
$71K - $187K *
Advance your career by leading innovative oncology research initiatives. Design and execute in vitro studies, develop bioanalytical methods, and collaborate cross-functionally to drive drug discovery...
2 days ago
Principal Scientist, Mechanistic & Cellular Pharmacology
$120K - $150K *
Join our team to lead the development of innovative cellular assays in immunology, drive cross-functional collaborations, and integrate cutting-edge AI/ML methods for drug discovery projects aiming to...
Yesterday
Principal Scientist, Mechanistic & Cellular Pharmacology
$120K - $150K *
Innovate with us in developing transformative therapies by leading drug discovery projects in immunology. Collaborate with multidisciplinary teams to progress from target identification to clinical de...
Yesterday
Scientist/Sr. Scientist - Protein Engineering
$71K - $187K *
Engage with a dynamic team to engineer, characterize, and optimize biotherapeutics, focusing on antibody development. Collaborate across disciplines to drive innovation and improve therapeutic outcome...
3 weeks ago
Senior Scientist, Stuctural Biology
$172K - $221K *
Join a team that's at the leading edge of structural biology, driving innovative drug discovery. Lead protein biochemistry efforts, mentor talent, and collaborate across functions to unlock new insigh...
2 weeks ago
Senior Research Associate , Automated Chemistry
$80K - $118K *
Join a team that's at the forefront of high-throughput Chemistry innovation, driving hands-on experimentation and automation. Contribute to critical projects using advanced technologies to impact scie...
4 days ago
$113K - $165K *
Transform innovative ideas into practical ML and AI applications by collaborating with multi-disciplinary teams to develop state-of-the-art solutions and prototypes for diverse projects in autonomous...
Yesterday
Staff / Senior Scientist, Assay Development (Automation)
$123K - $187K *
Champion the development of innovative assay workflows for nanopore sequencing, translating bench methods into automated protocols. Collaborate cross-functionally to optimize and validate processes, d...
2 weeks ago
Principal Scientist - Agentic Product
$248K - $360K *
Champion innovative engineering solutions by leading the architecture and development of cutting-edge AI-native products, while transforming workflows through AI tools and driving scalable, high-quali...
1 week ago
Principal Scientist - Agentic Product
$248K - $360K *
Join a team that's reshaping AI engineering by defining scalable architectures and fostering innovative practices that integrate generative models and AI tools in the development workflow for cutting...
1 week ago
Principal Scientist - Agentic Product
$190K - $360K *
Innovate in AI-driven engineering as a Principal Scientist, shaping architectures and enhancing developer experiences across diverse platforms. Collaborate with cross-functional teams, adopting best p...
1 week ago
Principal Scientist - Agentic Product
$190K - $360K *
Elevate the future of AI engineering by guiding architectural innovation and hands-on implementation for a transformative AI-native product. Collaborate across teams to define technical strategies and...
1 week ago
Principal Scientist, Upstream Development
$173K - $272K *
Elevate your career by leading the development of innovative upstream processes for biotherapeutics, guiding technical strategies, fostering collaboration, and mentoring junior scientists in a fast-pa...
2 weeks ago
Senior Scientist I, Potency and Impurities
$126K - $140K *
Partner with us to advance biotherapeutics by developing and qualifying potency assays, driving analytical strategies, and mentoring junior scientists in a collaborative, innovative environment...
2 days ago
Senior Scientist - Principal Scientist, Computational Chemistry
$120K - $150K *
Transform drug discovery processes by leveraging advanced computational chemistry techniques. Collaborate with scientists to synthesize innovative compounds and develop workflows that prioritize compo...
2 weeks ago
Principal Scientist, Upstream Process Development
$173K - $272K *
Grow your career with an opportunity to lead cross-functional teams in developing innovative CMC strategies for biologic processes, ensuring successful progression from early to late-stage clinical de...
6 days ago
Senior Scientist, Early Formulation Science and Drug Delivery, Drug Product Design
$93K - $156K *
Lead the charge in enhancing early drug delivery strategies by leveraging expertise in pharmaceutical sciences. Collaborate with cross-functional teams to evaluate drug candidates and design formulati...
2 weeks ago
What is the role of a Principal Scientist?
A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.
How much does a Principal Scientist earn on average?
The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.
What qualifications are required for Principal Scientist jobs?
Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.
Can I find remote Principal Scientist jobs on Ladders?
Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.