Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.
As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.
We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.
Principal Scientist, Analytical Sciences
$170K - $215K *
Join our innovative R&D team to lead analytical development for therapeutics in microgravity. Drive projects from conception to regulatory filing, while mentoring junior scientists, shaping product st...
5 days ago
$111K - $120K *
Lead the charge in R&D for cutting-edge filtration technologies across diverse sectors, driving innovation in microelectronics and aerospace. Collaborate with cross-functional teams to enhance product...
Reposted 5 days ago
$80K - $95K *
Optimize E&L study execution and compliance through strategic leadership, ensuring high-quality data for regulatory submissions while mentoring teams and aligning goals with product development initia...
2 days ago
Principal Scientist - Bioseparation & Analytical Development
$120K - $150K *
Lead the charge in advancing bioseparation analytical methods for large molecules. Drive innovation in biologics characterization, supporting drug development through hands-on execution and scientific...
3 weeks ago
$100K - $130K *
Elevate your scientific career by leading innovative LCMS initiatives, defining analytical strategies, and delivering impactful results within the pharmaceutical industry while mentoring emerging scie...
Reposted today
Principal Application Scientist | ELN/LUMA
$120K - $150K *
Unlock potential by leveraging deep scientific expertise and technical skills to partner with customers, ensuring the delivery of complex SaaS solutions while driving integration and data architecture...
2 weeks ago
$90K - $120K *
Innovate your career by providing analytical support for pharmaceutical development, conducting method validation, and leading studies while ensuring compliance and collaboration within a dynamic team...
2 weeks ago
$110K - $120K *
Lead innovative hair care formulation development from concept to market, utilizing advanced chemistry and collaboration across teams to overcome formulation challenges, ensure product safety, and dri...
2 weeks ago
Principal Scientist, Drug Substance Process Development & Manufacturing
$160K - $224K *
Join a team that drives Drug Substance development, overcoming complex challenges in monoclonal antibody manufacturing and scaling processes, while ensuring compliance and quality at every stage of pr...
3 weeks ago
$122K - $156K *
Join the forefront of scientific inquiry by leading impactful exposure science projects. Collaborate with diverse teams to mitigate health risks while enhancing your expertise through mentorship and c...
Reposted 4 days ago
Principal Associate Scientist, Biology
$108K - $122K *
Drive advancements in RNAi target discovery by independently executing molecular biology assays, managing cell cultures, and analyzing data to support neuroscience projects in a collaborative lab envi...
5 days ago
Principal Scientist, Analytical Development
$130K - $179K *
Unlock your potential as an analytical development lead, guiding innovative monoclonal antibody projects from preclinical to commercialization, ensuring compliance and delivering analytical excellence...
4 days ago
Principal Scientist, Specialty Toxicology
$135K - $150K *
Lead the charge in expanding preclinical studies in toxicology for cell and gene therapy programs. Ensure safety evaluations, provide expert guidance, and drive scientific innovation while mentoring j...
3 weeks ago
Senior Research Scientist, High Throughput Biology
$120K - $150K *
Take ownership of high throughput biology capabilities, designing and executing robust biochemical and cell-based assays while collaborating across teams to drive small molecule discovery and deliver...
3 weeks ago
$114K - $228K *
Drive clinical innovation by leading trial design and execution in collaboration with internal and external stakeholders to support regulatory submissions and strategic business goals within the vascu...
Reposted today
Expert Pharma Discovery Biologist
$120K - $150K *
Lead the charge in advancing oncology through in vitro discovery biology, collaborating across programs to validate targets and drive innovative therapeutic solutions...
1 week ago
Expert Pharma Discovery Biologist
$100K - $130K *
Join a team that's pioneering in vitro discovery biology to advance oncology programs, conducting target validation and developing innovative therapies across various modalities while driving research...
1 week ago
Managing Scientist (Ph.D. or M.S.)
$131K - $161K *
Lead and oversee pre-market approval projects in food safety; provide strategic regulatory guidance, manage multi-disciplinary projects, and mentor team members in this dynamic role focused on health...
Reposted 4 days ago
Principal Computational Scientist, Discovery Chemistry
$144K - $269K *
Lead advances in peptide therapeutic discovery by developing innovative computational methods and machine learning models to optimize peptide properties and streamline workflows for drug discovery...
2 weeks ago
Principal Scientist, Process Development (Expression Systems)
$142K - $256K *
Join a team that's pioneering microbial production strategies for recombinant enzymes and plasmids, driving high-performance screening workflows, and ensuring robust process development to support inn...
1 week ago
Senior Principal Scientist, Pre-Formulation and Materials Science
$124K - $207K *
Drive early-stage drug design and delivery as a Senior Principal Scientist, providing leadership and scientific strategy across multi-disciplinary teams to optimize molecular and drug formulation stra...
2 weeks ago
Principal Scientist, Clinical Biomarkers
$140K - $187K *
Drive biomarker strategy for clinical studies, ensuring data quality and compliance. Collaborate across functions and external partners to enhance clinical outcomes in solid organ transplant research...
1 week ago
$130K - $150K *
Unlock potential by joining a dynamic R&D team as a Senior Scientist in DMPK. Lead drug development through strategic planning, research execution, and collaboration to drive therapies from discovery...
3 weeks ago
Senior Scientist, Computational Safety
$140K - $222K *
Lead the charge in developing advanced AI/ML models for predictive toxicity assessments. Collaborate with cross-functional teams to integrate multi-modal biological data, driving insights that improve...
2 weeks ago
$100K - $130K *
Champion advanced sterile manufacturing processes, driving optimization and compliance in liquid and lyophilized parenteral operations while collaborating cross-functionally to enhance performance and...
1 week ago
What is the role of a Principal Scientist?
A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.
How much does a Principal Scientist earn on average?
The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.
What qualifications are required for Principal Scientist jobs?
Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.
Can I find remote Principal Scientist jobs on Ladders?
Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.