Position Summary:We are seeking a Senior Scientist, DMPK, to join our R&D group and work with an enthusiastic team of highly skilled scientists in a fast-pace environment. Reporting to the Senior Director, DMPK, this individual will be responsible for the design, execution, reviewing and interpreting the non-clinical DMPK data. This work supports the progression of therapies from discovery through first in human and proof of concept clinical studies. This is a great opportunity to contribute to an efficient DMPK function while being part of an exciting early-stage company.
Key Responsibilities:- Representative DMPK as a member of preclinical teams.
- Function as a key member of Atavistik Bio's scientific team, providing scientific expertise, strategic planning, and goal-oriented execution.
- Effectively communicate scientific planning, progress, results and challenges to R&D teams, and external audiences.
- Propose ADME/PK, biodistribution and PK-PD approaches at team discussions of high impact on project progression.
- Manage consultants and vendors to support DMPK studies.
- Partner with the discovery group to optimize preclinical models and inform on first in human clinical dosing strategies.
- Review preclinical study reports, in conjunction with Pharmacokinetics/DMPK and prepare regulatory submission documentation.
- Lead and oversee in-vitro ADME/DMPK assays (metabolic stability, CYP, PPB, permeability, solubility).
- Interpret DMPK data to guide structure-property relationships and compound selection.
- Support and interpret in-vivo PK and bioanalytical data (LC-MS/MS) and work collaboratively with the pharmacology leads to understand the PK/PD/Efficacy relationships.
- Develop DMPK strategies for hit-to-lead and lead optimization programs and inform on first in human clinical dosing strategies.
- Interface with CROs and external partners when needed.
- Collaborate cross functionally with all relevant areas to support strategic objectives.
Required Qualifications:- PhD., Pharm. D. or equivalent training in pharmacokinetics, pharmaceutical sciences, or related disciplines.
- 5+ years of experience in bio/pharmaceutical industry, combined with drug development.
- Excellent communication and collaborative skills to work on multiple project teams including chemists, biologists and platform scientists.
- Highly organized, self-motivated with a desire to succeed in a fast-paced organization.
- Solid understanding of drug metabolism, bioanalysis, pharmacokinetics, preclinical pharmacology, and PK/PD modeling.
- Expertise in SAR analysis and IVIVC.
- Expertise managing CROs, GLP and other regulated activities.
- Ability to operate objectively and independently as a leader and as a member of a team.
- Experience with regulatory submissions for small molecules with a focus on preclinical is a plus.
- Experience in nonclinical toxicology is a plus.
$130,000 - $150,000 a year
Benefits:Atavistik Bio offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.
