Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$120K - $145K *

Drive the future of AI & Analytics by leading client relationships, providing strategic guidance, and delivering innovative solutions. Leverage your expertise to enhance service delivery and ensure al...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$120K - $150K *

Accelerate progress at the forefront of newborn health by leading strategic initiatives, managing multi-country programs, and driving impactful interventions to reduce neonatal mortality and stillbirt...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $100K *

Help us optimize Epic applications by leading projects, troubleshooting issues, and ensuring seamless integration. Collaborate with teams to enhance workflows and provide expert support, all while mai...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $220K *

Join a team that's shaping clinical sales strategies and enhancing client relationships. Lead initiatives that drive market growth and improve patient satisfaction while collaborating across disciplin...

Harrisburg, PARemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $95K *

Transform patient care by leading a neuro rehabilitation team while providing hands-on therapy. This role combines clinical expertise with leadership, ensuring quality outcomes for individuals recover...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in building strategic relationships with key travel agencies, optimizing settlement operations, and enhancing distribution technologies to drive efficiency and growth in the travel eco...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$100K - $200K *

Unlock potential by engaging homeowners to assess comfort needs and deliver tailored HVAC solutions. Leverage company-generated leads in a consultative sales role with strong support and industry-lead...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$90K - $110K *

Transform client relationships by delivering tailored financial advice and solutions. Leverage your expertise to support diverse clients, ensuring a holistic approach to their financial needs while fo...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Unlock your potential as you provide tailored financial planning and advice to diverse clients. Leverage your expertise to build relationships and deliver exceptional service, fostering a culture of i...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$79K - $124K *

Elevate nursing leadership by supervising care operations, ensuring compliance, and fostering a collaborative environment to enhance resident outcomes and staff performance in a dynamic healthcare set...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $149K *

Unlock potential by leading commissioning and testing for electrical power systems. Collaborate with teams to ensure operational excellence, technical quality, and customer satisfaction while troubles...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$190K - $300K *

Build strategic relationships with scientific leaders to drive innovation in Pulmonary Hypertension. Engage in scientific exchange, support research initiatives, and enhance understanding of therapeut...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$93K *

Drive the future of fundraising by managing donor relationships and securing major gifts. Collaborate with leadership and teams to cultivate prospects, implement strategies, and achieve financial goal...

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$67K - $100K *

Drive operational excellence by supporting the development and maintenance of standardized playbooks, SOPs, and workflows. Collaborate with cross-functional teams to ensure clarity and consistency in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$150K - $250K *

Explore a rewarding outside sales role where you design customized bath solutions for homeowners, leveraging cutting-edge technology and a proven sales process to achieve unlimited earning potential i...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Optimize fundraising operations by leading a dynamic team, enhancing data practices, and driving strategic initiatives to support sustainable philanthropic growth and effective donor engagement...

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$112K - $236K *

Drive strategic decision-making by evaluating investment alternatives and lifecycle opportunities. Collaborate with cross-functional teams to optimize portfolio value and support program planning thro...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead the charge in building a secure, self-service developer sandbox on Azure, delivering non-persistent desktops and managing the entire stack from landing zone to golden image while ensuring complia...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Accelerate your career by leading Army business development, transforming priorities into funded opportunities. Drive strategy from engagement to award, collaborating with key stakeholders to ensure s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$157K - $185K *

Analyze and own AI Security sales in your territory, driving the full sales cycle from prospecting to closing. Collaborate with Account Executives to penetrate enterprise accounts and shape product of...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$183K - $220K *

Lead talent acquisition and relations, managing a team to secure top instructors. Drive strategic partnerships and streamline operations while maintaining high-profile relationships and ensuring succe...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Elevate manufacturing processes by optimizing operations, conducting trials, and leading engineering initiatives. Collaborate across teams to enhance safety, quality, and efficiency while driving cont...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Oversee and manage engineering and administrative functions for advanced technology projects, ensuring effective communication and compliance across all project teams while maintaining safety and qual...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Optimize data infrastructure by leading the design and development of scalable data pipelines, ensuring efficient processing and actionable insights through visualization, while mentoring junior team...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $90K *

Drive innovative advertising strategies by transforming customer insights and performance data into compelling creative content. Collaborate with cross-functional teams to enhance product visibility a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.