Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$366K - $472K *

Lead the charge in incubating Multicloud Fabric, driving customer acquisition and sales strategies while collaborating cross-functionally to ensure product success and market fit...

1 week ago

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$90K - $110K *

Champion patient care by conducting psychiatric evaluations and medication management, collaborating with healthcare teams to ensure timely and effective treatment while maintaining compliance with re...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $190K *

Lead the charge in shaping user experiences by driving product design strategy, mentoring teams, and collaborating with cross-functional partners to tackle complex enterprise challenges and enhance de...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Transportation

$105K - $155K *

Join a team that's redefining social media in healthcare. Lead strategic initiatives, drive impactful campaigns, and mentor talent while collaborating with clients to elevate their social presence acr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$194K - $270K *

Shape the future of our strategic initiatives by leading high-impact projects that drive innovation and collaboration across teams. Partner closely with executive leadership to deliver measurable resu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the charge in transforming product vision into market success by leveraging customer insights, strategic positioning, and cross-functional collaboration to drive impactful go-to-market strategies...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $140K *

Drive impactful design solutions for developer tools, collaborating closely with engineers and PMs. Own workflows from discovery to delivery, enhancing user experiences and contributing to a robust de...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$88K - $124K *

Drive the resolution of complex Surety Claims through investigation, evaluation, and negotiation. Collaborate with internal and external resources while mentoring junior staff to ensure effective clai...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$127K - $260K *

Transform your career by leading the design and implementation of a comprehensive learning ecosystem for Assurance teams, fostering high-performance and collaboration across the organization to enhanc...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$120K - $145K *

Shape the future of digital transformation by leading a dynamic team to deliver innovative solutions that enhance business efficiency and customer experience across multi-functional AWS programs...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$200K - $250K *

Join us to architect and lead the development of scalable fintech solutions. As a technical leader, you'll drive innovation, mentor teams, and ensure architectural integrity while shaping the future o...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$129K - $173K *

Join a team that's redefining API integration by leveraging your expertise to guide customers in automating service processes. Collaborate with technical sellers and enhance API adoption through effec...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$104K - $176K *

Lead the operational strategy for partner ecosystems, managing processes and technology to enhance partner engagement and streamline workflows. Drive automation and data integrity while collaborating...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $165K *

Lead traffic engineering projects, driving analysis and design for major transportation initiatives. Collaborate with teams to ensure compliance with standards while mentoring engineers and managing p...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$73K - $110K *

Drive coding quality and compliance by analyzing data, supporting audits, and enhancing documentation practices. Collaborate with teams to ensure accurate coding and adherence to regulatory standards...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Empower patient care by leveraging your nursing expertise in the Operating Room. Collaborate with a dynamic team to enhance surgical outcomes and support innovative practices in a fast-paced environme...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Contribute to transformative healthcare by supervising APPs in a dynamic neurosurgery department, ensuring exceptional patient care and leading a collaborative team focused on innovative neurointerven...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Join a team that's redefining retail technology by architecting innovative merchandising software solutions. Collaborate remotely while leading projects that enhance asset management and streamline wo...

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Join a team that's dedicated to delivering exceptional pharmaceutical care by reviewing medication records, dispensing medications, and supervising pharmacy staff while ensuring compliance with regula...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$83K - $125K *

Drive the operational health of mission-critical Appian environments, ensuring reliability and performance. Collaborate with cross-functional teams to manage configurations, deployments, and incident...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$70K - $114K *

Transform your career by advancing our Enterprise Risk Management Program. Collaborate with teams to identify, assess, and mitigate risks, ensuring alignment with strategic objectives and regulatory s...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $150K *

Lead complex project management initiatives across multiple channels in the pharmaceutical advertising sector. Oversee cross-functional teams, ensuring timely delivery within budget while mentoring ju...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$79K - $91K *

Transform lives by providing individualized behavioral therapy to children and adolescents. Collaborate with multidisciplinary teams to develop treatment plans, train caregivers, and monitor progress...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$113K - $151K *

Join a team that's transforming digital marketing solutions by developing innovative strategies and engaging presentations for enterprise clients, while collaborating across functions to drive impactf...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$126K - $157K *

Drive your career forward by leading complex software projects, collaborating with diverse teams, and leveraging cutting-edge technologies to deliver high-quality solutions that meet client needs and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.