Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$129K - $162K *

Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$69K - $104K *

Advance the quality of child and youth services by evaluating agency performance, analyzing data, and providing strategic guidance to ensure compliance with state and federal standards, fostering cont...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Transform operations by driving safety, quality, and productivity in a collaborative environment. Coach talent, enhance customer satisfaction, and lead continuous improvement initiatives to elevate pe...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $235K *

Join a team that's redefining business processes through digital transformation. Lead cross-functional initiatives, ensuring scalable and standardized practices that align with strategic goals while f...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower enterprise automation by designing, developing, and optimizing solutions using Automation Anywhere, Python, and Power Apps. Collaborate with cross-functional teams to deliver scalable, secure...

Pennsylvania, USRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Drive the end-to-end revenue lifecycle and lead a high-performing team in optimizing order-to-cash operations. Collaborate cross-functionally to ensure compliance with ASC 606 while enhancing automati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $95K *

Drive operational excellence across multiple retail locations, enhancing customer experience and achieving KPIs. Lead, mentor, and develop diverse teams while ensuring compliance with standards and fo...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$120K - $145K *

Lead the Validation and Process Engineering teams to ensure compliance and efficiency in pharmaceutical manufacturing. Oversee equipment validation, project management, and cross-department collaborat...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a dynamic team to drive sales of AI solutions to community banks and credit unions. Manage the full sales cycle, from pipeline generation to closing, while exceeding quotas in a fast-paced, high...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$102K - $163K *

Lead the charge in designing and overseeing digital instrumentation and control systems, ensuring compliance with industry regulations while coordinating workflows and schedules with subcontractors to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$75K - $100K *

Reimagine talent acquisition by leading full-cycle recruiting efforts, collaborating with leadership to forecast hiring needs, and enhancing employer branding to attract top talent while ensuring comp...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$103K - $181K *

Transform user experiences by developing and enhancing frontend applications using JavaScript, React, and TypeScript. Collaborate in an Agile environment to deliver high-quality software solutions whi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $120K *

Lead the charge in delivering high-quality patient care as an Advanced Practice Provider. Collaborate closely with a dynamic surgical oncology team, utilizing clinical expertise to support patients th...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Transform health care delivery by collaborating with primary care leaders to drive value-based reimbursement strategies that enhance clinical and financial outcomes for all stakeholders...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$88K - $154K *

Analyze and enhance compensation strategies, ensuring competitive and compliant practices. Collaborate with HR and management to optimize job descriptions, conduct market analysis, and deliver insight...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$80K - $95K *

Manage respiratory services across the Patient Care Division, promoting interdisciplinary collaboration, staff development, and quality patient care while overseeing clinical operations and budget adh...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$182K - $200K *

Unlock innovative solutions by leading a distributed team, driving software quality, and promoting best practices for scalable applications in a collaborative and agile environment...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$100K - $152K *

Unlock your potential by designing high-voltage transmission lines, leading project teams, and collaborating with clients. Utilize your engineering expertise to drive innovative solutions and mentor j...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$95K - $178K *

Unlock your potential by providing systems administration and security support for diverse IT environments. Collaborate on automation development and ensure compliance while enhancing operational effi...

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$95K - $115K *

Analyze employment law issues, provide strategic advice, and manage litigation phases while collaborating with diverse teams to support clients in HR and compliance matters...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$120K - $150K *

Join a team that's transforming marketing workflows through AI and automation. Leverage your marketing expertise to enhance efficiency and effectiveness across various platforms, driving impactful cha...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Drive business growth by leading end-to-end capture efforts in cybersecurity and intelligence sectors. Engage customers, shape strategies, and close deals while owning the full lifecycle of opportunit...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $200K *

Lead high-impact client delivery operations, ensuring quality execution and resource optimization across diverse projects. Collaborate with cross-functional teams to drive performance and enhance cust...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$144K - $184K *

Join an innovative engineering team to transform product delivery through AI-driven development, ensuring high standards and compliance while combining product, design, and engineering leadership acro...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Oversee construction inspections to ensure compliance with project specifications, proactively identify issues, and document findings. Collaborate with project management to provide effective solution...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.