Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$219K - $285K *

Shape and lead a centralized commercial analytics function, transforming complex data into actionable insights. Drive performance measurement, growth identification, and strategic decision-making acro...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$235K - $350K *

Transform the future of cyber defense by architecting cutting-edge AI systems that autonomously protect against real-world threats. Lead technical direction, mentor teams, and drive innovation from re...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$100K - $145K *

Elevate your career by managing Kubernetes clusters across diverse environments. Collaborate with senior engineers to automate processes, troubleshoot issues, and enhance platform performance while de...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $160K *

Play a key role in managing a team of engineers, fostering collaboration, and driving technical excellence in innovative chemical solutions while ensuring project efficiency and quality compliance...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Collaborate with HR and legal teams to provide comprehensive employment law support, drafting and negotiating contracts while ensuring compliance with regulations. Balance legal risks with business ob...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$174K - $234K *

Shape the future of Hematology analytics by leading strategic insights and performance initiatives. Collaborate with cross-functional teams to enhance field execution and drive commercial success thro...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$105K - $140K *

Lead the charge in monitoring clinical study sites, ensuring data integrity and patient safety while collaborating with diverse teams to enhance study delivery and compliance with regulatory standards...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$74K - $124K *

Elevate compensation strategies by transforming complex data into actionable insights. Collaborate with stakeholders to manage compensation programs, analyze trends, and recommend solutions that ensur...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$485K *

Transform franchise growth in the Extended Stay sector by leading strategic initiatives, managing a team of Regional Vice Presidents, and building key relationships to enhance development opportunitie...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$162K - $207K *

Lead the charge in implementing and optimizing SAP Vistex solutions, translating business strategies into technical architecture while managing cross-functional teams and project deliverables for enha...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$129K - $185K *

Unlock potential by leading the Customer Identity & Access Management function, overseeing CIAM platform operations, and driving identity strategy across global digital ecosystems while collaborating...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $135K *

Unlock potential by leading the technical architecture and roadmap for email marketing. Collaborate across teams to enhance platform capabilities, ensuring effective audience targeting and reliable de...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $162K *

Unlock potential by developing effective strategies and relationships to drive sales growth in the territory, ensuring compliance with regulations and high levels of customer engagement through effect...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$75K - $105K *

Lead and elevate the customer experience while managing daily operations of the Collision Center. Drive performance through effective coaching, budget management, and adherence to quality standards, e...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$115K - $135K *

Lead the charge in managing complex credit workouts, evaluating borrower plans, and negotiating exit strategies while ensuring compliance and integrity in loan documentation and processes...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$104K - $145K *

Elevate product development by defining, designing, and prototyping features for a merchant portal, leveraging AI tools and user feedback to enhance payment processing solutions rapidly and effectivel...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$89K - $134K *

Explore your potential as a key analytical consultant, leveraging data to optimize drug pricing and enhance pharmacy relationships while collaborating across multiple functions to drive strategic grow...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Engage in leading a dynamic team to enhance IAM/IGA capabilities, ensuring secure access and operational excellence while driving automation and collaboration across technology and business stakeholde...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Drive innovative digital financial solutions by leading product management efforts, collaborating with cross-functional teams, and enhancing user experiences to empower participants in their financial...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$105K - $165K *

Shape the future of AI platforms by leading strategy, architecture, and engineering for scalable, secure solutions. Drive innovation while ensuring compliance and operational excellence across enterpr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $192K *

Drive your career with a dynamic team focused on neurology sales. Collaborate with healthcare professionals and internal partners to exceed launch objectives and enhance patient care in your territory...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $192K *

Shape the future of neurology sales by collaborating with healthcare professionals and driving demand generation. Leverage your expertise to meet launch objectives and enhance patient care through str...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$136K - $187K *

Lead patient education and support initiatives for individuals affected by generalized Myasthenia Gravis. Collaborate with caregivers and healthcare teams to enhance treatment coordination and empower...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$136K - $187K *

Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $192K *

Empower healthcare professionals by driving demand in the Neurology Franchise. Collaborate with local teams to execute strategies, support launches, and exceed sales objectives while maintaining a pat...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.