Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,459

Sort By: Relevance

$190K - $210K *

Collaborate with cross-functional teams to drive clinical biomarker strategy and execution, translating discovery insights into actionable approaches that enhance patient outcomes in early neuroscienc...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Take ownership of payroll operations, ensuring accuracy and compliance while leading a team to deliver timely wage payments and manage tax obligations effectively across the organization...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Accelerate progress at the forefront of digital transformation by leading high-impact Microsoft initiatives. Drive adoption of AI and low-code solutions, manage cross-functional teams, and shape strat...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$116K - $229K *

Transform commercial operations by leveraging AI and analytics to drive innovative solutions for Life Sciences clients. Collaborate with high-performing teams to enhance data-driven decision-making an...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$116K - $229K *

Innovate data-driven solutions for Life Sciences, leveraging AI and analytics to transform commercial operations. Collaborate with teams to deliver insights and optimize strategies for pharma clients...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$126K - $158K *

Lead sales operations to drive revenue growth and optimize team performance. Oversee planning, forecasting, and reporting while ensuring alignment with organizational goals. Collaborate with cross-fun...

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$90K - $130K *

Manage visual inspection operations, ensuring compliance with safety and quality standards while driving efficiency and team performance. Lead investigations and audits, fostering a culture of continu...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$126K - $158K *

Unlock potential by leading sales operations to drive revenue growth and team productivity. Collaborate with cross-functional leaders to optimize strategies, enhance performance, and ensure alignment...

Pittsburgh, PARemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$128K - $205K *

Engage with Thai Cuisine restaurants to drive growth through consultative sales. Utilize your bilingual skills to convert leads, conduct demos, and build relationships, ensuring a tailored experience...

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$145K - $180K *

Transform retail operations by serving as the primary SAP POS expert for DoD S/4HANA implementations, ensuring alignment with operational goals and financial reporting while bridging technical teams a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $185K *

Unlock your potential as a Project Director, leading innovative health research initiatives. Drive strategic planning and capture opportunities while managing a dynamic team to tackle complex public h...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Redefine pharmaceutical care by managing staff and overseeing medication processes. Ensure quality, safety, and cost-effectiveness in drug therapy while collaborating with healthcare professionals to...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$63K - $111K *

Empower mission success by assessing utility vulnerabilities and enhancing infrastructure resilience against diverse threats. Collaborate with a multidisciplinary team to ensure operational continuity...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$150K - $250K *

Transform financial services by leading complex banking operations and technology projects. Collaborate with clients to enhance performance, drive innovation, and shape a new practice within a dynamic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$99K - $165K *

Transform sourcing strategies by leading initiatives across key spend categories, collaborating with stakeholders to optimize supplier performance, mitigate risks, and drive cost savings while ensurin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$137K - $245K *

Shape the future of physical operations by driving AI-powered product innovation. Collaborate across teams to identify customer needs, prototype solutions, and deliver impactful products that enhance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$162K - $243K *

Elevate your career by leading the development of optimization models and digital tools that enhance decision-making across the NG & NGL value chain, collaborating with cross-functional teams to drive...

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$65K - $99K *

Execute geotechnical field and lab testing for infrastructure projects, ensuring compliance with safety and quality standards. Collaborate with senior technicians and engineers to support drilling ope...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Shape the future of healthcare by leading complex implementations across provider and payor organizations. Drive project success through collaboration, strategic planning, and innovative solutions whi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$133K - $237K *

Contribute to patient safety by overseeing medical product surveillance, analyzing data, and ensuring compliance with regulations. Collaborate on risk management and support clinical studies to enhanc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$102K - $184K *

Elevate your career by leading market-level financial reporting and performance management in value-based healthcare. Collaborate with stakeholders to drive insights and outcomes, ensuring disciplined...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Shape the future of manufacturing operations by leading cross-departmental initiatives, optimizing processes, and driving efficiency. Collaborate with teams to implement policies and achieve organizat...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead and coordinate business development, customer relations, and quality management activities to enhance private pay services, ensuring operational excellence and growth in a dynamic healthcare envi...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Champion privacy solutions by engaging with clients, delivering tailored demos, and driving sales success. Leverage your expertise to influence product development and navigate the intersection of AI...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$230K - $300K *

Elevate your career by leading commercial due diligence engagements, partnering with corporate and private equity clients to assess growth potential and risks. Drive insights that influence strategic...

1 week ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.