Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $122,395

Sort By: Relevance

$95K - $115K *

Lead the design and development of innovative VG Systems, enhancing product quality and operational efficiency. Collaborate with cross-functional teams to drive technical improvements and influence st...

6 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$53K - $132K *

Engineer financial forecasts for clinical trials, collaborating with teams to ensure accuracy and enhance processes. Analyze data, manage stakeholder communications, and drive operational excellence t...

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$53K - $132K *

Unlock client potential by ensuring maximum value from products and services. Collaborate with teams to build relationships, monitor performance, and deliver tailored solutions that enhance satisfacti...

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in defining and activating brand strategies across multiple channels, enhancing donor engagement and retention through innovative content and social communications while collaborating...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$317K - $409K *

Lead the charge in clinical strategy design and execution, guiding cross-functional teams to ensure high-quality clinical development aligned with regulatory standards and project goals. Drive innovat...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $130K *

Champion innovative solutions in FinTech as a Sales Engineer, providing technical expertise and support for SEC/EDGAR products. Engage with clients through demos, build relationships, and drive sales...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$106K - $160K *

Lead complex contract negotiations and drive strategic supplier relationships. Collaborate with stakeholders to assess risks, develop negotiation strategies, and enhance contracting practices while me...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$95K - $115K *

Join our team to enhance clinical systems for medication management, focusing on optimizing workflows and supporting pharmacy operations. Collaborate with stakeholders to ensure accuracy and efficienc...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$168K - $231K *

Unlock potential by leading the design and development of innovative software solutions for medical devices. Collaborate with cross-functional teams to ensure high-quality, secure software that enhanc...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $189K *

Support Department of Defense operations by configuring SAP S/4HANA for finance and logistics. Collaborate with stakeholders to enhance enterprise systems, ensuring seamless integration and compliance...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$63K - $129K *

Shape your career by driving Agile execution excellence in federal HCM modernization. Lead cross-functional teams, facilitate SAFe ceremonies, and foster a continuous improvement culture within a larg...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$69K - $141K *

Transform infrastructure through innovative DevSecOps practices, collaborating with a skilled team to enhance software deployment and operational efficiency while ensuring security and compliance in a...

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $189K *

Empower our team as a Product Owner, leading strategic execution and collaboration with engineering to define features, manage backlogs, and ensure successful delivery of mission-critical software sol...

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$114K - $252K *

Unlock potential by leading software development initiatives, ensuring system integration, and guiding teams through agile methodologies to deliver high-quality solutions that meet customer requiremen...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $150K *

Champion innovative workforce solutions by leading strategic initiatives that enhance education and training programs, driving revenue growth and community engagement to meet evolving regional workfor...

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Champion innovative marketing and pricing strategies to drive growth and enhance brand visibility. Lead a dynamic team to analyze market trends, optimize customer journeys, and implement data-driven d...

6 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$110K - $130K *

Lead and execute regulatory strategies for multi-region clinical trials, ensuring compliance and timely submissions. Collaborate with project teams to manage risks and drive operational excellence thr...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$118K - $180K *

Join a dynamic team enhancing nuclear power plants through advanced engineering. Leverage your expertise in thermodynamics and fluid mechanics to drive power uprate projects, mentor junior staff, and...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $152K *

Empower progress in environmental compliance by developing air permitting strategies for complex industrial projects. Collaborate with multi-disciplined teams to ensure adherence to air quality regula...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Technical Services

$145K - $222K *

Lead a structural engineering team, guiding projects for nuclear facilities. Utilize your expertise in design and analysis while collaborating with clients and multidisciplinary teams to deliver innov...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Technical Services

$132K - $174K *

Shape the future of environmental consulting by leading complex projects, fostering client relationships, and driving strategic initiatives. Collaborate with multidisciplinary teams to ensure excellen...

RemoteRemote

6 days ago

  •   11 - 15 years exp.  •   Energy & Utilities

$110K - $130K *

Elevate product execution by translating client needs into actionable requirements, collaborating with engineering and data science teams to deliver standardized measurement solutions across various c...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$89K - $113K *

Transform data integrity by assisting in the analysis and cleansing of Enterprise Business Systems. Collaborate with teams to resolve anomalies and ensure compliance with DoD standards while supportin...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$82K - $99K *

Advance your career by providing exceptional outpatient orthopedic care. Collaborate with a diverse patient mix and orthopedic physicians in a supportive environment focused on compliance and communic...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$84K - $100K *

Advance your career as a Physical Therapist in a dynamic outpatient setting. Collaborate with a diverse patient population and orthopedic specialists while ensuring compliance and delivering exception...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.