Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$110K - $130K *

Unlock innovation by designing scalable system architectures for rail solutions. Collaborate with cross-functional teams to ensure robust, future-ready systems that enhance mobility and safety, drivin...

Today

  •   Less than 5 years exp.  •   Energy & Utilities

$85K - $100K *

Join a team that's dedicated to enhancing the health of frail elderly participants through comprehensive assessments and care management, collaborating with specialists to ensure optimal health outcom...

Today

  •   Less than 5 years exp.  •   Healthcare

$188K - $265K *

Accelerate progress at the forefront of AI infrastructure by leading technical direction, ensuring platform architecture meets company ambitions, and fostering collaboration across engineering teams f...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$124K - $158K *

Transform patient care by leading the pharmacy team, ensuring compliance, and delivering exceptional pharmacy services. Support the continuous improvement of health outcomes while fostering a culture...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$124K - $158K *

Champion patient care and pharmacy excellence while leading a dedicated team. Drive operations and compliance in a fast-paced environment, supporting health improvements through accurate dispensing, c...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$81K - $95K *

Shape the future of payments by supporting sales teams with tailored presentations and analytics. Collaborate with C-Level executives to foster new business relationships and enhance client engagement...

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$113K - $155K *

Champion quality excellence by executing business programs across manufacturing sites, collaborating with cross-functional teams to enhance product standards, manage consumer insights, and drive conti...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Food & Beverages

$120K - $170K *

Partner with us to drive business development and consulting efforts in environmental investigations. Leverage your expertise in analytical chemistry and project management to enhance client engagemen...

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$120K - $170K *

Drive business growth by engaging clients and leading environmental consulting projects. Leverage expertise in analytical chemistry and project management to deliver high-quality solutions while maint...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$214K - $309K *

Unlock potential by leading the design and implementation of advanced identity solutions for AI agents. Collaborate across teams to build scalable frameworks and drive technical excellence in a dynami...

RemoteRemote

Today

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$180K - $220K *

Lead the charge in global product distribution quality management, overseeing strategies, compliance, and organizational development across all Olympus locations while ensuring regulatory communicatio...

Today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$87K - $105K *

Drive revenue growth by clinically selling EndoTherapy devices to the Gastroenterology community. Build relationships with key stakeholders, provide product training, and implement strategic business...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Oversee security operations and ensure the safety of all visitors while optimizing department goals. Collaborate with teams to establish best practices, manage budgets, and implement emergency respons...

Reposted today

  •   5 - 7 years exp.  •   Business Services

$108K - $130K *

Drive project success by leveraging technical expertise and leadership skills. Collaborate with cross-functional teams to ensure timely delivery of milestones while fostering continuous improvement in...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$200K *

Drive technical excellence by translating creative visions into actionable plans. Oversee pre-production, CAD drafting, and on-site execution, ensuring projects are delivered safely, on time, and with...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$100K - $148K *

Transform customer experiences by engaging early in renewal processes, leveraging technical expertise to address challenges and enhance product value. Collaborate cross-functionally to drive successfu...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$62K - $103K *

Join a team that's dedicated to maximizing revenue through strategic account management, focusing on military bases. Drive sales growth by understanding customer needs and implementing effective solut...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$78K - $87K *

Shape environmental solutions by conducting assessments and remediations. Collaborate with engineers and scientists on diverse projects, ensuring regulatory compliance and delivering impactful results...

Today

  •   Less than 5 years exp.  •   Technical Services

$78K - $87K *

Shape the future of environmental consulting by conducting assessments, analyzing data, and developing remediation strategies. Collaborate with a dynamic team to tackle challenging projects across the...

Today

  •   Less than 5 years exp.  •   Technical Services

$80K - $95K *

Lead the charge in teaching enterprise technology integration, focusing on real-world applications. Collaborate with faculty to innovate curricula while mentoring students in capstone projects. Engage...

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Lead the delivery of reporting and analytics solutions, ensuring alignment with business objectives. Collaborate with stakeholders to gather requirements, validate data quality, and drive continuous i...

Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$92K - $154K *

Join a team that's redefining digital design verification for high-performance networking IP. Contribute to scalable verification environments, collaborate with cross-functional teams, and ensure the...

Today

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Elevate your career by supporting AI-driven strategies, collaborating globally, and enhancing student experiences through innovative feedback mechanisms and project management. Drive impactful change...

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$137K - $235K *

Shape the future of quality assurance by leading strategic initiatives that enhance compliance, operational effectiveness, and inspection readiness while driving innovation in the pharmaceutical indus...

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Lead the charge in transforming identity security marketing strategies, driving growth and market leadership. Oversee a dynamic team to enhance product positioning, execute go-to-market plans, and sha...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.