Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Associate Director/Director, Asset Acquisition
$190K - $250K *
Analyze and evaluate therapeutic opportunities to drive innovation and business development. Collaborate with interdisciplinary teams to assess scientific and commercial viability, ensuring alignment...
Today
Senior Director, Contact Center
$150K - $180K *
Lead the future of patient experience by driving strategic initiatives and operational excellence in a high-volume healthcare contact center. Collaborate with cross-functional teams to enhance service...
Reposted yesterday
Behavioral Health Medical Director
$223K - $313K *
Shape the future of behavioral health care strategy and operations. Leverage your medical expertise to enhance quality, operational efficiency, and patient outcomes while navigating complex regulatory...
Reposted yesterday
$95K - $115K *
Champion data-driven decision-making by bridging clinical operations and analytics. Lead projects, deliver actionable insights, and enhance performance across clinics while managing stakeholder commun...
6 days ago
$90K - $110K *
Unlock potential by driving new business sales in a dynamic, AI-enabled environment. Own your territory, create a robust pipeline, and engage sophisticated buyers to deliver consistent revenue growth...
Yesterday
Management Analyst (Human Resources)
$80K - $95K *
Help us enhance federal human capital operations through independent analysis, strategic recommendations, and effective program delivery. Collaborate on data-driven insights to improve efficiency and...
Reposted 1 week ago
Remote Quality Improvement Data Analyst
$70K - $106K *
Transform operational data into actionable insights while collaborating with cross-functional teams to support business decisions and enhance efficiency. Leverage analytical skills to drive performanc...
Reposted 3 days ago
Account Manager, Molecular Diagnostics, QIAstat (Midwest)
$100K - $120K *
Advance healthcare solutions by driving sales of innovative diagnostic instruments. Engage with key stakeholders to promote QIAstat-Dx systems, ensuring successful adoption and customer satisfaction t...
3 days ago
Executive Director, Key Accounts Lead
$228K - $285K *
Shape the future of market access by leading strategic account initiatives, fostering key relationships, and driving collaboration across teams to enhance product access and reimbursement in the oncol...
1 week ago
$90K - $115K *
Join a dynamic team as a Senior Project Planner, driving financial health and vendor coordination across multiple brands while ensuring project success through strategic planning and effective communi...
3 days ago
$130K *
Shape the future of non-profit engagement by leading sales initiatives, driving pipeline growth, and fostering client relationships. Leverage your strategic sales expertise to elevate our impact and a...
Reposted 3 weeks ago
Head of Business Development, Pharma/Life Sciences
$200K *
Transform the landscape of life sciences partnerships by driving co-developed deals. Leverage your extensive network and expertise to source, pitch, and close high-value agreements that enhance patien...
Today
Director, Client Coding Integration
$97K - $145K *
Join a dynamic team to lead physician coding integration initiatives, ensuring operational readiness and compliance. Collaborate across departments to enhance coding practices and drive revenue cycle...
Yesterday
Director, Client Coding Integration
$120K - $145K *
Execute accurate coding practices to ensure compliance and optimal reimbursement in a dynamic healthcare environment. Collaborate with clinical teams to maintain integrity and efficiency in revenue cy...
Reposted 1 week ago
$78K - $98K *
Transform customer experiences by leading complex software implementations, ensuring seamless onboarding, testing, and launch activities. Leverage advanced product knowledge and project coordination s...
4 weeks ago
Senior Business Analyst – Electronic Health Record (EHR) Systems
$97K - $125K *
Drive impactful change by analyzing user needs and defining requirements for clinical applications. Collaborate with diverse teams to enhance electronic health record systems, ensuring effective docum...
5 days ago
DRG Quality Analyst IV - Healthcare
$85K - $110K *
Optimize clinical DRG audits by ensuring accuracy and consistency in coding. Mentor auditors, recommend process improvements, and conduct quality reviews to enhance performance and compliance in a rem...
1 week ago
Director, Business Improvement
$150K - $180K *
Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...
1 week ago
Assistant General Counsel, Corporate & Securities
$160K - $190K *
Transform corporate governance and compliance by advising on legal matters, preparing SEC filings, and managing risk programs. Collaborate with stakeholders to ensure adherence to regulations while dr...
Today
$61K - $98K *
Transform the landscape of risk management by overseeing collections and funding returns, analyzing transaction patterns, and collaborating with teams to resolve complex cases while driving process im...
1 week ago
$110K - $130K *
Accelerate your career by driving revenue growth with enterprise clients. Leverage your sales expertise in the fashion industry to build relationships, identify needs, and deliver tailored solutions t...
2 days ago
Director, Access Strategy & Marketing
$201K - $251K *
Elevate access strategies and marketing initiatives for oncology products, focusing on non-clinical value propositions. Collaborate cross-functionally to ensure successful product launches and effecti...
3 days ago
$150K - $180K *
Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...
3 weeks ago
Senior Manager, Solutions Consulting
$230K - $280K *
Lead a high-performing team to enhance Solutions Consulting, drive cross-functional collaboration and ensure the success of strategic accounts through innovative, accountable deal execution and contin...
Reposted 3 weeks ago
Senior Manager, Discovery Operations
$120K - $145K *
Shape the future of discovery operations by leveraging your legal expertise and leadership skills to enhance service delivery and team performance, ensuring top-quality results and efficient workflows...
Reposted 4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.