Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $116,335
Nurse Practitioner Palliative Care
$95K - $115K *
Join a dedicated team as you provide advanced palliative care, enhancing patients' quality of life while managing complex medical needs. Collaborate with healthcare professionals to deliver compassion...
1 week ago
Senior Software Engineer - Virtual Machines (RD222)
$125K - $150K *
Transform your career by owning complex software features that integrate virtual machines into a secure platform. Collaborate across teams to deliver innovative solutions while establishing strong eng...
1 week ago
Principal Solution Architect - Security
$165K - $231K *
Transform complex security challenges into innovative solutions for public-sector and commercial clients. Lead technical pre-sales efforts, collaborating with sales teams to deliver tailored architect...
1 week ago
Senior Digital Product Owner (FinOps)
$110K - $130K *
Lead FinOps strategy and governance, enhancing cost transparency and accountability across cloud and AI services. Collaborate with stakeholders to optimize financial management practices and drive inf...
1 week ago
$160K - $185K *
Unlock your potential by leading a dynamic team to drive channel partnerships, transforming opportunities into revenue-generating relationships across diverse verticals in a fast-growing ecosystem...
1 week ago
$172K - $222K *
Pioneer innovative production techniques as you lead creative projects from concept to delivery. Collaborate with teams to explore AI-driven methods while ensuring exceptional quality across diverse f...
1 week ago
Security Control Assessor - Intermediate
$80K - $95K *
Manage comprehensive security assessments to evaluate IT system controls, ensuring compliance with NIST standards. Collaborate on risk management strategies and develop security processes to enhance o...
1 week ago
$165K - $195K *
Engage in strategic solution development for Federal Government initiatives, translating client needs into innovative technical strategies. Collaborate with cross-functional teams to deliver compellin...
1 week ago
$105K - $132K *
Join a team that's dedicated to optimizing employee benefits programs. You'll manage US benefits operations, enhance vendor performance, and shape global strategies, ensuring a seamless, employee-cent...
1 week ago
Hematology Therapeutic Specialist (LA North)
$110K - $130K *
Join a team that's dedicated to advancing hematology care by educating healthcare providers and driving demand for innovative therapies. Leverage your expertise to foster relationships and ensure a po...
1 week ago
D&T Sr Project Management Consultant - Talent Community
$110K - $130K *
Elevate your project management career by leading a strategic platform within investor client coverage, enhancing client engagement and driving technology integration across CBRE's commercial real est...
Reposted 1 week ago
Oil & Gas/Chemical Segment Leader
$119K - $190K *
Deliver strategic growth in the Oil & Gas and Chemical sectors by identifying opportunities, building executive relationships, and enabling sales. Leverage industry expertise to shape market strategie...
1 week ago
Workday Ecosystem Business Development Senior Manager
$122K - $261K *
Accelerate strategic growth by driving opportunities in Workday technologies, fostering executive relationships, and leading transformative initiatives across industries to enhance client engagement a...
1 week ago
(USA) Assistant General Manager II
$116K - $174K *
Shape the future of transportation operations by leading teams to optimize freight movement, enhance service levels, and drive continuous improvement initiatives within a dynamic distribution network...
1 week ago
$80K - $130K *
Lead dealership implementations by managing go-lives, training teams, and ensuring seamless integrations. Collaborate with stakeholders to optimize workflows and drive adoption, while traveling freque...
1 week ago
$80K - $95K *
Drive your career with a Senior Compensation Analyst role focused on designing and administering competitive compensation programs. Collaborate with HR and finance leaders to enhance talent strategies...
Reposted 1 week ago
$100K - $120K *
Advance global clinical trials by leading cross-functional teams, ensuring compliance and operational excellence while managing timelines and budgets to deliver impactful results in Oncology research...
1 week ago
Head and Neck Oncology ENT Mercy Springfield MO Comprehensive Cancer Program at 886 bed Hospital
$240K - $300K *
Contribute to a leading cancer program by joining a collaborative team of experts in head & neck surgery, focusing on microvascular reconstruction and oncology, while enjoying a balanced lifestyle and...
Reposted 1 week ago
$80K - $95K *
Champion radiation safety across multiple departments, ensuring compliance with federal and state regulations. Oversee the safe use of radioactive materials and x-rays, while leading a team of profess...
Reposted 1 week ago
Forward Deployed Engineer (TypeScript + AI) - Remote - USA
$120K - $145K *
Accelerate progress at the intersection of engineering and AI, embedding with enterprise teams to architect and deliver robust AI solutions that meet real-world demands in regulated industries...
1 week ago
$135K *
Elevate client success by leading innovative training programs that enhance learning experiences. Drive product adoption and satisfaction through tailored onboarding and ongoing education, ensuring cl...
1 week ago
Customer Success Manager (Public Sector)
$95K - $115K *
Join a team that's dedicated to enhancing customer success in cybersecurity. Leverage your expertise to build trusted relationships, drive product adoption, and ensure client satisfaction while naviga...
1 week ago
Sr. Manager, Provider Data Operations & Attribution Integrity
$67K - $199K *
Empower operational excellence by leading provider data governance and attribution processes. Collaborate across departments to ensure data integrity, enhance reporting accuracy, and drive continuous...
1 week ago
Talent & Workforce Industry & Process Advisor Manager, Banking
$94K - $293K *
Unlock potential by leading transformative talent strategies that integrate AI and workforce analytics. Drive innovation in talent processes, enhance client relationships, and shape the future of work...
1 week ago
HR Reinvention Industry & Process Advisor Manager, Banking
$87K - $253K *
Elevate your career by leading HR transformation initiatives that integrate AI and process redesign. Drive impactful change for clients, enhancing HR functions to deliver superior business outcomes an...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.