Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$95K - $115K *

Join a dedicated team as you provide advanced palliative care, enhancing patients' quality of life while managing complex medical needs. Collaborate with healthcare professionals to deliver compassion...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Transform your career by owning complex software features that integrate virtual machines into a secure platform. Collaborate across teams to deliver innovative solutions while establishing strong eng...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$165K - $231K *

Transform complex security challenges into innovative solutions for public-sector and commercial clients. Lead technical pre-sales efforts, collaborating with sales teams to deliver tailored architect...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead FinOps strategy and governance, enhancing cost transparency and accountability across cloud and AI services. Collaborate with stakeholders to optimize financial management practices and drive inf...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $185K *

Unlock your potential by leading a dynamic team to drive channel partnerships, transforming opportunities into revenue-generating relationships across diverse verticals in a fast-growing ecosystem...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$172K - $222K *

Pioneer innovative production techniques as you lead creative projects from concept to delivery. Collaborate with teams to explore AI-driven methods while ensuring exceptional quality across diverse f...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Manage comprehensive security assessments to evaluate IT system controls, ensuring compliance with NIST standards. Collaborate on risk management strategies and develop security processes to enhance o...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$165K - $195K *

Engage in strategic solution development for Federal Government initiatives, translating client needs into innovative technical strategies. Collaborate with cross-functional teams to deliver compellin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $132K *

Join a team that's dedicated to optimizing employee benefits programs. You'll manage US benefits operations, enhance vendor performance, and shape global strategies, ensuring a seamless, employee-cent...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's dedicated to advancing hematology care by educating healthcare providers and driving demand for innovative therapies. Leverage your expertise to foster relationships and ensure a po...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate your project management career by leading a strategic platform within investor client coverage, enhancing client engagement and driving technology integration across CBRE's commercial real est...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$119K - $190K *

Deliver strategic growth in the Oil & Gas and Chemical sectors by identifying opportunities, building executive relationships, and enabling sales. Leverage industry expertise to shape market strategie...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$122K - $261K *

Accelerate strategic growth by driving opportunities in Workday technologies, fostering executive relationships, and leading transformative initiatives across industries to enhance client engagement a...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$116K - $174K *

Shape the future of transportation operations by leading teams to optimize freight movement, enhance service levels, and drive continuous improvement initiatives within a dynamic distribution network...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $130K *

Lead dealership implementations by managing go-lives, training teams, and ensuring seamless integrations. Collaborate with stakeholders to optimize workflows and drive adoption, while traveling freque...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Drive your career with a Senior Compensation Analyst role focused on designing and administering competitive compensation programs. Collaborate with HR and finance leaders to enhance talent strategies...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Advance global clinical trials by leading cross-functional teams, ensuring compliance and operational excellence while managing timelines and budgets to deliver impactful results in Oncology research...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$240K - $300K *

Contribute to a leading cancer program by joining a collaborative team of experts in head & neck surgery, focusing on microvascular reconstruction and oncology, while enjoying a balanced lifestyle and...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Champion radiation safety across multiple departments, ensuring compliance with federal and state regulations. Oversee the safe use of radioactive materials and x-rays, while leading a team of profess...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Accelerate progress at the intersection of engineering and AI, embedding with enterprise teams to architect and deliver robust AI solutions that meet real-world demands in regulated industries...

Jefferson City, MORemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K *

Elevate client success by leading innovative training programs that enhance learning experiences. Drive product adoption and satisfaction through tailored onboarding and ongoing education, ensuring cl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Join a team that's dedicated to enhancing customer success in cybersecurity. Leverage your expertise to build trusted relationships, drive product adoption, and ensure client satisfaction while naviga...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$67K - $199K *

Empower operational excellence by leading provider data governance and attribution processes. Collaborate across departments to ensure data integrity, enhance reporting accuracy, and drive continuous...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$94K - $293K *

Unlock potential by leading transformative talent strategies that integrate AI and workforce analytics. Drive innovation in talent processes, enhance client relationships, and shape the future of work...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$87K - $253K *

Elevate your career by leading HR transformation initiatives that integrate AI and process redesign. Drive impactful change for clients, enhancing HR functions to deliver superior business outcomes an...

1 week ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.