Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From positions in Jackson and the Gulf Coast to opportunities in communities across the state, find roles that match your experience, skills, and career goals.

Professional Opportunities Across Mississippi

Mississippi employers hire experienced professionals across industries such as healthcare, finance, manufacturing, technology, energy, and business operations. Available roles and compensation vary by employer, location, and qualifications, so review each listing for details about responsibilities, salary, and requirements.

Search in Mississippi Cities and Regions

Find opportunities in major employment centers including Jackson, Gulfport, and Southaven, as well as other Mississippi communities. Use location and job-title filters to focus your search, and consider remote or hybrid listings when available.

Find a Role That Fits Your Career

Compare opportunities by seniority, specialty, and work arrangement. Keep your résumé current, highlight measurable results, and tailor your application to the qualifications in each listing. Ladders helps professionals explore vetted jobs with salaries of at least $100,000.

Start Your Mississippi Job Search

Browse Mississippi jobs on Ladders and take the next step toward a professional opportunity aligned with your expertise and compensation goals. Listings change frequently, so check back for new roles.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$110K - $130K *

Transform pharmacy outcomes by leading managed care initiatives that optimize clinical programs, enhance stakeholder collaboration, and drive cost efficiencies in pharmacy benefit management...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$96K - $207K *

Lead the charge in managing complex credit liquidations and rehabilitations. Collaborate with Portfolio Managers to optimize returns while ensuring compliance and risk management, fostering a positive...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$97K - $151K *

Unlock potential by managing agency relationships and driving sales growth in assigned territories. Utilize training, data analysis, and strategic initiatives to enhance performance and engagement, en...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$286K - $326K *

Champion engineering excellence by leading high-performing teams to innovate scalable, customer-centric solutions. Drive technical strategy and architecture while fostering a culture of continuous lea...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Join a team that's dedicated to optimizing privacy management processes and compliance technology. This role supports platform administration, user engagement, and operational improvements, ensuring e...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Manage the operational backbone of multiple HCI portfolios by coordinating and executing initiatives, engaging with diverse stakeholders, and overseeing project timelines, budgets, and deliverables fo...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$227K - $313K *

Elevate your career by leading strategic reimbursement initiatives, optimizing revenue cycles, and collaborating with key stakeholders to enhance patient access and billing processes in a dynamic heal...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$129K - $218K *

Join a team that's redefining business communications for agent and broker sectors. As a strategic leader, you'll shape narratives, prioritize initiatives, and ensure cohesive messaging across channel...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $195K *

Empower quality assurance excellence by leading GMP oversight for contract manufacturing and validation projects, ensuring compliance and collaboration across technical operations to support drug deve...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $180K *

Join a team that's revolutionizing the CI/CD landscape by automating golden image lifecycle management across Linux, macOS, and Windows. Contribute your expertise to enhance image deployment efficienc...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Innovate user experiences by leveraging AI tools to enhance design processes, ensuring intuitive and accessible digital solutions. Collaborate with cross-functional teams to drive strategic UX initiat...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$121K - $170K *

Drive your career forward as a strategic leader, guiding enterprise-level technology solutions. Engage with executive stakeholders, architect innovative multi-practice solutions, and influence digital...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $220K *

Join us to lead the strategic management and optimization of software systems across a global organization, ensuring reliability, innovation, and efficiency while fostering strong partnerships between...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Empower our rehabilitation team by leading operations, ensuring compliance, and enhancing patient care. Drive financial success and foster strong relationships with staff and clients while maintaining...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $160K *

Drive your career with a data-driven Performance Marketing Manager role, optimizing paid acquisition programs across multiple channels to convert marketing investments into qualified leads and new cus...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$129K - $216K *

Drive impactful partnerships in oncology research by managing site relationships, optimizing clinical trial execution, and enhancing operational efficiency for successful outcomes in a dynamic researc...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Transform patient care as a lead dermatology APP, delivering high-quality medical services while establishing a new practice. Collaborate with physician leadership to shape workflows and grow a loyal...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $215K *

Shape the future of our commercial launch by leading a regional sales team to drive market entry, foster customer relations, and exceed performance goals in a dynamic, cross-functional environment...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $125K *

Grow key accounts in the Casino Gaming sector by driving business expansion, identifying opportunities, and delivering tailored computing solutions. Engage with C-level executives to enhance partnersh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $200K *

Elevate the engineering department by driving delivery, managing teams, and ensuring production quality. Lead hands-on development while fostering innovation in AI-driven systems to enhance operationa...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Optimize end-to-end project delivery by developing customer-facing products and internal tools. Collaborate with stakeholders to rapidly turn needs into functional solutions, leveraging AI and modern...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $110K *

Elevate your career by building key relationships and driving sales growth in the medical device sector. Leverage your expertise to expand accounts and enhance profitability while providing essential...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Pioneer innovative reinsurance solutions by leveraging your expertise and relationships. Drive business growth through strategic client engagement, deal structuring, and market insights while collabor...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$102K - $170K *

Lead strategic initiatives and operational excellence as a key partner to the VP/GM, driving accountability and cross-functional coordination to enhance business performance and accelerate growth acro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Drive strategic partnerships and optimize alliances to enhance revenue growth. Lead co-sell initiatives and ensure seamless partner engagement, leveraging data insights to maximize impact in AI and cl...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of jobs can I find in Mississippi on Ladders?question toggle

    You can explore professional opportunities across fields such as healthcare, finance, manufacturing, technology, energy, and business operations. Roles and availability vary over time.

  • Are Mississippi jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs that pay $100,000 or more. Check each listing for compensation details, qualifications, and other job-specific information.

  • Where in Mississippi can I search for jobs?question toggle

    Search across the state, including employment centers such as Jackson, Gulfport, and Southaven. You can use location filters to narrow results.

  • How can I find remote or hybrid jobs based in Mississippi?question toggle

    Use available work-arrangement filters or review listing details to identify remote and hybrid opportunities. Availability depends on the employer and role.

  • How do I improve my chances of getting hired for a Mississippi job?question toggle

    Tailor your résumé to the role, emphasize relevant experience and measurable outcomes, and ensure you meet the listed qualifications before applying.