Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$95K - $125K *

Elevate security practices by integrating SAST/DAST into CI/CD pipelines, hardening infrastructure with Ansible, and ensuring compliance with federal standards. Collaborate on vulnerability management...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $97K *

Accelerate progress at our team by developing and deploying full-stack solutions. Collaborate on REST APIs, enhance legacy applications, and ensure secure coding practices while delivering high-qualit...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $125K *

Join a team that's shaping the future of federal technology solutions. As a Technical Lead, you'll guide product development, oversee architecture, and mentor teams while ensuring compliance and secur...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $105K *

Drive cloud infrastructure excellence by managing environments, automating deployments, and ensuring security. Collaborate on cloud migrations and capacity planning while producing essential documenta...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$105K - $125K *

Engage as a Technical Lead, guiding product architecture and sprint execution while mentoring teams and ensuring compliance with VA standards. Drive technical strategy and oversee troubleshooting for...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $92K *

Empower teams to excel by facilitating Agile practices, coaching on SAFe 6.0, and managing sprint processes. Collaborate with stakeholders to ensure project success and drive continuous improvement in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $90K *

Elevate patient care by preparing individuals for surgery through thorough assessments, education, and collaboration with surgical teams, ensuring a seamless and compassionate preoperative experience...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$101K - $146K *

Lead the charge in managing complex casualty claims, ensuring timely evaluations and settlements while collaborating with stakeholders to uphold coverage standards and compliance. Drive efficiency in...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$95K - $115K *

Join a team that's dedicated to providing exceptional pharmaceutical care and clinical services. You'll manage medication orders, supervise healthcare teams, and contribute to departmental goals while...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Help us enhance patient care by diagnosing and managing health issues, collaborating with healthcare teams, and advocating for individuals and communities in diverse settings. Your expertise will driv...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$160K - $180K *

Join us as a strategic operator to drive high-priority growth initiatives, aligning cross-functional teams and transforming ideas into actionable plans while leveraging AI tools for enhanced efficienc...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$104K - $161K *

Champion growth by managing agency relationships and driving revenue in your territory. Develop and implement best practices to enhance sales performance while analyzing market trends to achieve profi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K *

Partner with us to enhance product knowledge through comprehensive training programs, ensuring effective customer support and the growth of clinical expertise in the field sales organization. Be a cli...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $90K *

Lead change and drive excellence in safety, quality, and customer experience. Collaborate with teams to enhance productivity and implement process improvements while mentoring a dedicated workforce in...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$116K - $146K *

Manage quality assurance for PV EPC projects, ensuring compliance with standards and regulations. Oversee inspections, audits, and training while collaborating with teams to enhance project quality an...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Lead the charge in shaping market strategies and messaging for innovative traffic management solutions, collaborating across teams to drive customer engagement and adoption through compelling content...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$100K - $120K *

Elevate traffic management solutions by driving revenue through strategic partnerships with government agencies. Cultivate relationships, identify opportunities, and execute sales strategies to achiev...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$135K - $168K *

Drive exceptional patient care by leading a pharmacy team, promoting best practices, and ensuring compliance. Cultivate a culture of excellence while managing operations and enhancing patient experien...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$75K - $100K *

Join a team that's dedicated to enhancing information security and compliance operations. This mid-level role focuses on supporting security workflows, documentation, and IT service desk escalations...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Lead the charge in overseeing flight operations, ensuring safety and efficiency while advancing aerospace technologies through interdisciplinary research and collaboration with stakeholders...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$185K - $344K *

Champion the evolution of field intelligence capabilities, driving strategic governance and analytics integration to enhance decision-making and execution support across the organization, ensuring ali...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$57K - $178K *

Champion the administration of estates and trusts, ensuring compliance and accuracy in tax filings while managing client relationships and case documentation. Leverage your expertise to deliver except...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$90K - $110K *

Pioneer a unified marketing infrastructure by managing automation platforms, lead intelligence, and analytics. Collaborate with cross-functional teams to enhance data governance and optimize marketing...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Advance global drug safety initiatives by leading pharmacovigilance activities, ensuring compliance with regulations, and collaborating with cross-functional teams to enhance product safety and operat...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$143K - $194K *

Join a team that drives the execution of integrated media plans, ensuring compliance and operational excellence. Collaborate with cross-functional teams while enhancing brand strategies in healthcare...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.