Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,580
Sr. Director, Integrated Evidence Generation Lead
$175K - $210K *
Lead pioneering evidence generation initiatives to inform oncology product strategies and lifecycle management through cross-functional collaboration and data-driven decision-making...
Reposted 1 week ago
Senior Game Application Security Analyst
$177K - $265K *
Join a team that's dedicated to safeguarding player experiences by investigating and combating cheating in games. Leverage your analytical skills to create data-driven reports and collaborate with eng...
Reposted 1 week ago
Senior Engineering Manager, Platform
$150K - $180K *
Lead and grow a high-performing platform engineering team, setting vision and roadmap while collaborating with cross-functional leaders to enhance product velocity and reliability for enterprise custo...
1 week ago
$146K - $206K *
Join a dynamic team to build secure customer authentication features, enhancing user experiences across B2C and B2B platforms. Collaborate with engineers to develop backend services and APIs, ensuring...
1 week ago
$80K - $95K *
Lead the charge in client strategy and Meta campaign management, ensuring optimal performance and strong relationships. Own a portfolio of accounts, drive results, and proactively solve issues to enha...
1 week ago
$80K - $95K *
Take ownership of client relationships and campaign performance, managing a portfolio of accounts. Lead strategy discussions, optimize Meta campaigns, and ensure client satisfaction through proactive...
1 week ago
$125K - $150K *
Innovate AI solutions by developing tools and integrations that enhance workflows, drive efficiency, and empower teams. Collaborate across departments to implement scalable AI applications that delive...
1 week ago
Structural Project Designer - Nuclear
$94K - $143K *
Lead the charge in developing structural designs using advanced modeling software. Collaborate with multi-disciplinary teams to create detailed drawings and resolve design challenges, ensuring timely...
1 week ago
$162K - $200K *
Unlock your potential by serving as a key legal partner, guiding commercial transactions and enhancing our legal infrastructure while collaborating cross-functionally to drive efficiency and complianc...
1 week ago
Staff Product Manager, Databases
$190K - $285K *
Shape the future of database protection by owning the Oracle roadmap, collaborating with engineering teams, and driving cross-database initiatives to enhance recovery solutions for critical enterprise...
1 week ago
$150K - $180K *
Transform enterprise sales strategies by identifying and addressing client needs in Logistics and Manufacturing. Drive national account growth through innovative solutions, relationship building, and...
1 week ago
$87K - $108K *
Join a team that's shaping the future of water and energy utilities by leading proposal development, coordinating resources, and implementing winning strategies. Collaborate with experts to create imp...
1 week ago
$130K - $180K *
Make your mark at a leading veterinary practice, providing critical emergency care to pets. Collaborate with a dedicated team in a well-equipped facility, handling diverse cases while enjoying mentors...
1 week ago
$100K - $120K *
Manage day-to-day operations and maintenance of critical facilities, ensuring seamless execution of integrated plans while addressing emergencies and performance standards. Lead a team to optimize fac...
1 week ago
$95K - $115K *
Lead the charge in overseeing facility operations and project execution, ensuring seamless integration across maintenance, IT, and electrical operations while managing performance deficiencies and cor...
1 week ago
Global Commercial Vehicle Sales Leader
$188K - $230K *
Unlock your potential by leading a global sales team, driving growth strategies, and fostering relationships with key OEMs and suppliers in the Commercial Vehicle sector. Collaborate across functions...
1 week ago
$75K - $158K *
Join a team that's dedicated to optimizing operations in a fast-paced environment. Support technical and functional stakeholders while ensuring seamless processing and troubleshooting across systems...
1 week ago
Research Scientist II - Deepfake Detection & Authentication (Video & Audio)
$160K - $185K *
Contribute to groundbreaking research in deepfake detection and identity authentication. Drive innovative projects, collaborate with engineers, and translate complex models into scalable solutions, en...
1 week ago
$108K - $130K *
Empower enterprise infrastructures by designing automated workflows for secure, scalable network management. Utilize advanced scripting and automation to optimize systems while leveraging your experti...
Reposted 1 week ago
Nurse Practitioner / Physician Assistant - Texas
$140K - $150K *
Join a team that's dedicated to transforming addiction treatment through telehealth. Collaborate with physicians to provide comprehensive care for patients with substance use disorders, ensuring a sup...
1 week ago
$160K - $180K *
Transform digital healthcare services by designing and deploying scalable machine learning models. Collaborate with cross-functional teams to enhance predictive capabilities and ensure compliance with...
1 week ago
$108K - $130K *
Drive successful battery energy storage projects by managing installations, ensuring quality, and maintaining customer satisfaction. Collaborate with cross-functional teams to deliver projects on time...
1 week ago
$184K - $200K *
Unlock potential by driving the vision and strategy for innovative products that empower independent candidates and enhance user engagement. Collaborate with cross-functional teams to create scalable...
Reposted 1 week ago
Junior Salesforce Developer | Public Health
$81K - $98K *
Advance your career by leveraging your public health expertise and Salesforce skills to develop impactful solutions. Collaborate with a dedicated team to enhance public health technology, ensuring it...
Reposted 1 week ago
Client Partner - Consumer Products & Retail (remote)
$210K - $250K *
Transform client relationships and drive AI-led growth in the Consumer Products, Manufacturing & Retail sectors. Lead strategic accounts, mentor teams, and shape innovative solutions to enhance busine...
1 week ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.