Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$97K - $115K *

Drive strategic partnerships by managing key technology alliances, focusing on Microsoft. Collaborate across teams to identify growth opportunities, enhance partner engagement, and align initiatives w...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$120K - $145K *

Join a team that's building and scaling a data and analytics platform to enhance clinical AI performance. Collaborate with cross-functional teams to create actionable insights and drive improvements i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$295K - $325K *

Drive strategic sales leadership across the Western US, translating brand vision into effective field execution. Build and sustain a high-performing team while collaborating cross-functionally to achi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$112K - $179K *

Shape the future of data-driven insights by leveraging advanced machine learning techniques, collaborating with cross-functional teams, and communicating complex analyses to drive impactful business d...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $160K *

Lead the charge in executing population health strategies, ensuring high-quality consulting delivery and team performance across regions. Collaborate with leadership to drive impactful solutions and f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $140K *

Transform infrastructure and deployment modernization efforts, serving as a technical cornerstone for multiple programs. Drive DevSecOps maturity and cloud adoption while ensuring secure, rapid delive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$101K - $165K *

Transform co-marketing initiatives by executing strategic campaigns across diverse channels. Collaborate with partners and cross-functional teams to drive revenue growth, enhance brand awareness, and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $120K *

Advance strategic initiatives by collaborating across teams to launch innovative data tools and insurance programs. Drive project management efforts and contribute to executive presentations that shap...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $165K *

Join a dynamic team to oversee complex life application underwriting, ensuring risk selection aligns with financial goals. Drive process improvements and collaborate with stakeholders to enhance servi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$85K - $100K *

Drive clinical excellence by partnering with agency leaders to assess, develop, and deliver tailored education programs for nursing staff, ensuring compliance and enhancing patient care across a netwo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$223K - $313K *

Shape the future of behavioral health care strategy and operations. Leverage your medical expertise to enhance quality, operational efficiency, and patient outcomes while navigating complex regulatory...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$123K - $207K *

Elevate enterprise systems by leading design and enhancements, ensuring reliability and usability. Collaborate with cross-functional teams to translate requirements into scalable solutions while drivi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$200K - $250K *

Unlock the potential of Open Source and AI governance by leading a multidisciplinary team to ensure compliance, drive best practices, and foster innovation across the enterprise, while collaborating w...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$108K - $130K *

Contribute to the development of innovative web applications using .Net, Angular, and SQL. Collaborate with a dynamic team to enhance existing systems and design new solutions, ensuring high-quality s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $125K *

Champion data engineering excellence by designing and maintaining robust data pipelines and analytics solutions. Collaborate with stakeholders to enhance data quality and support enterprise-level data...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $130K *

Optimize the employee experience through innovative engagement strategies and precise HR operations. Be a key player in fostering a vibrant culture while ensuring operational excellence in onboarding...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$104K - $161K *

Accelerate progress at driving agency relationships and revenue growth in the commercial trucking sector. Manage a diverse portfolio of accounts while implementing best practices to enhance sales perf...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$91K - $141K *

Empower agency growth by managing relationships and driving performance in Nebraska and Kansas. Lead strategic initiatives, deliver training, and ensure accountability to achieve sales goals while fos...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Join us to tackle complex challenges as a strategic technical leader, influencing product direction and driving customer success. Your expertise will shape innovative solutions while engaging directly...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Help us ensure high-quality decision-making by collaborating with leaders to frame strategies and analyze options, driving impactful decisions that align with organizational goals and values while fos...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$77K - $135K *

Join us to manage a diverse portfolio of 90-120 real estate assets, ensuring lease compliance and fostering strong landlord relationships while solving complex challenges across North America...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$196K - $210K *

Partner with us to shape the future of semiconductor workforce development by aligning industry needs with educational strategies, fostering partnerships, and leading initiatives that ensure technical...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$98K - $134K *

Champion user-centered design as a Senior Product Designer, leading onboarding experiences that empower educators and learners. Collaborate across teams to create intuitive, impactful solutions that s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Transform developer experiences by designing intuitive growth-focused products. Collaborate with a dedicated team to enhance usability, streamline onboarding, and boost retention for impactful voice-d...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $169K *

Unlock your potential as you design and enhance go-to-market programs that drive sales productivity and revenue growth. Collaborate with cross-functional teams to translate strategy into actionable in...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.