Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$120K - $145K *

Unlock potential by leading the strategy and roadmap for a connected care platform, enhancing patient experiences through integrated technology solutions in healthcare settings. Drive product vision...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Deliver comprehensive patient care by assessing, diagnosing, and managing health issues. Collaborate with healthcare professionals and advocate for patients while enhancing nursing practices and suppo...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$88K - $105K *

Optimize patient care quality and safety through strategic leadership, data-driven initiatives, and collaboration with healthcare teams to enhance service delivery and compliance with regulatory stand...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Join a dynamic team to elevate client relationships and deliver exceptional wealth management services, supporting key investment strategies and ensuring client satisfaction with detailed financial an...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Accelerate our events strategy by managing end-to-end logistics, driving engagement, and optimizing performance to enhance customer relationships and sales opportunities across diverse sectors...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$62K - $100K *

Drive SaaS conversion initiatives by collaborating with teams to assess risks, readiness, and opportunities. Engage with customers to facilitate migrations and ensure effective communication throughou...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Engage with clients to enhance their cybersecurity resilience by leading incident response efforts, providing expert guidance, and preparing detailed reports to mitigate risks and improve security pos...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$155K - $185K *

Partner with us to lead high-impact projects in healthcare marketing, managing budgets and teams while ensuring creative excellence and strategic alignment. Drive client success through collaboration...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $246K *

Champion innovative IAM solutions by designing secure software and optimizing SaaS services. Collaborate across teams to embed security practices, conduct threat modeling, and enhance monitoring syste...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Lead operations as you manage production, engineering, quality, and sales teams. Drive continuous improvement and ensure safety while fostering a culture of teamwork and accountability to deliver supe...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$75K - $94K *

Shape exceptional client experiences by leading AV production and design projects. Collaborate across sectors to ensure successful event execution while building lasting relationships and maintaining...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$120K - $145K *

Lead the development of AI-driven document extraction solutions, ensuring accuracy and efficiency. Collaborate with cross-functional teams to prioritize features and manage product roadmaps, driving i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$193K - $238K *

Unlock potential by driving enterprise sales strategies to acquire new clients. Engage with C-level executives, manage key accounts, and exceed revenue goals while advocating for innovative EHS soluti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$466K - $500K+*

Join a team that's shaping the future of AI by designing and building scalable platforms for large-scale machine learning model training, enhancing performance, and creating user-friendly experiences...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$190K - $250K *

Analyze and evaluate therapeutic opportunities to drive innovation and business development. Collaborate with interdisciplinary teams to assess scientific and commercial viability, ensuring alignment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Lead the charge in enhancing organizational security by developing security frameworks, assessing controls, and collaborating with technical teams to create a resilient security architecture for moder...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $160K *

Champion the evolution of Workday PSA by architecting scalable solutions that integrate finance and operations. Lead major initiatives from design to implementation, ensuring alignment with global sta...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Transform customer HR environments by implementing and optimizing AI solutions. Collaborate with clients to configure integrations, troubleshoot issues, and enhance workflows, ensuring seamless deploy...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$185K - $315K *

Join us to shape strategic financial planning and analysis, leveraging AI to enhance forecasting and decision-making. This high-impact role collaborates with executives, driving insights that align wi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Consumer Technology

$85K - $124K *

Champion innovative project management solutions, guiding teams through configuration, product demonstrations, and stakeholder collaboration to deliver value-driven consulting services that adapt to e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Take ownership of SSP partnerships to optimize programmatic supply, enhance monetization, and ensure compliance. Collaborate with cross-functional teams to drive revenue growth and improve inventory q...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$70K - $110K *

Champion the resolution of complex Tier 3 auto claims, leveraging expertise in investigation, liability assessment, and negotiation to ensure effective outcomes while serving as the primary contact fo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$200K *

Transform the landscape of life sciences partnerships by driving co-developed deals. Leverage your extensive network and expertise to source, pitch, and close high-value agreements that enhance patien...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$150K - $180K *

Advance healthcare solutions by building executive relationships and driving enterprise sales. Lead the sales lifecycle, develop strategic accounts, and leverage modern tools to optimize revenue growt...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Elevate your career by leading the strategic growth of our Attorney Banking Division. Drive business development, mentor a remote team, and enhance client experiences while achieving personal producti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.