Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,580
$150K - $180K *
Shape and execute a comprehensive partnership strategy to drive growth, enhance market presence, and foster high-value alliances across the healthcare ecosystem, collaborating with executive leadershi...
6 days ago
$110K - $130K *
Champion transformative initiatives by translating priorities into actionable plans, coordinating cross-functional teams, and driving organizational change to enhance operational effectiveness and ado...
6 days ago
Key Account Leader, Mid Cities East
$110K - $140K *
Lead the charge in driving sales for mid-sized public safety agencies, managing full-cycle deals from opportunity identification to closing. Collaborate with cross-functional teams to ensure successfu...
6 days ago
$106K - $167K *
Join us to analyze and optimize complex business processes, design ERP solutions, and lead integration efforts. Collaborate with teams to enhance performance and ensure compliance while delivering hig...
Reposted 6 days ago
$160K - $190K *
Pioneer innovative AI solutions to transform biomedical discovery, collaborating with top scientists and engineers to bridge virtual and real-world data, enhancing drug discovery and clinical care pro...
6 days ago
Clinical Applications Specialist
$80K - $95K *
Help us deliver exceptional training and support for medical imaging equipment, enhancing customer experiences through expertise and mentorship while traveling frequently to engage with healthcare pro...
6 days ago
$73K - $102K *
Join a team that's transforming ERP solutions by customizing and integrating systems to meet business needs. Collaborate with stakeholders to enhance performance and ensure compliance while delivering...
6 days ago
$110K - $130K *
Drive AI-powered marketing initiatives to optimize campaigns, enhance pipeline generation, and leverage automation. Collaborate cross-functionally while experimenting with emerging technologies to red...
6 days ago
Mission Integration Lead - Survivable Airborne Operations
$130K - $150K *
Unlock potential by leading the design and integration of secure, resilient network architectures for mission-critical systems, ensuring operational performance and recovery objectives are met through...
6 days ago
$80K - $120K *
Shape the future of data-driven decision-making by developing innovative data products and AI solutions. Collaborate with cross-functional teams to deliver impactful analytics and automation tools tha...
6 days ago
Territory Sales Manager (IOWA)
$97K - $151K *
Lead the growth of agency relationships to enhance profitability in your territory. Oversee the execution of strategic initiatives, manage agent performance, and deliver training to drive success in G...
6 days ago
$92K - $153K *
Join a team that's dedicated to enhancing patient access by managing reimbursement challenges and providing education to healthcare providers. This role requires strong relationship-building skills an...
6 days ago
Senior Frontend Engineer, Ads Formats
$190K - $267K *
Drive impactful ad experiences by leveraging your frontend expertise in JavaScript and TypeScript. Collaborate with cross-functional teams to enhance user engagement and optimize ad performance across...
6 days ago
Manager, Corporate Communications - Software
$81K - $128K *
Unlock potential by shaping integrated corporate communications strategies that connect software innovation with community impact, bridging B2B and B2C narratives to advance fraud prevention and eleva...
Reposted 6 days ago
Senior Director of Engineering
$261K - $308K *
Transform Women's Health engineering by leading a high-impact team to deliver innovative software solutions. Collaborate across functions to shape strategy and drive organizational excellence while en...
6 days ago
Microsoft Power Platform Tech Lead / Architect
$113K - $147K *
Pioneer innovative solutions as a Microsoft Power Platform Architect, leading enterprise-grade design and implementation. Collaborate with stakeholders to enhance efficiency, automate processes, and d...
6 days ago
Manager, Data Protection Analysts (Americas)
$120K - $145K *
Shape the future of data protection by leading a high-performing team of analysts. Drive incident response, enhance security strategies, and collaborate with clients to mitigate risks in a fast-paced...
6 days ago
Talent Acquisition and Employee Engagement Manager
$100K - $120K *
Partner with us to shape the future of talent acquisition and employee engagement. Lead strategies that attract, retain, and support exceptional talent while enhancing the employee experience across a...
6 days ago
Sr. Manager, Global Channel Partner Marketing
$135K - $160K *
Shape the future of partner marketing by building and executing joint plans with key resellers and distributors, driving engagement and pipeline growth through innovative campaigns and strategic commu...
6 days ago
$150K - $180K *
Unlock your potential as a Senior Applied AI Engineer, leading teams to design and deliver impactful AI solutions. Drive technical excellence and mentor engineers while shaping the future of AI system...
6 days ago
Senior Product Manager (Healthcare Data Products)
$120K - $145K *
Transform healthcare data products by leading strategy, execution, and cross-functional collaboration. Drive product-market fit and commercialization for API-based solutions, ensuring alignment with c...
6 days ago
Sales Manager - Australia/New Zealand Market
$100K - $120K *
Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...
Reposted 6 days ago
$95K - $115K *
Transform procurement operations by leading strategy and team management in a regulated manufacturing environment. Drive supplier performance, cost efficiency, and material availability to support pro...
6 days ago
Software Engineer 4/5 - Model Serving Systems, AI Platform
$466K - $500K+*
Unlock potential by developing scalable AI/ML model serving infrastructure. Collaborate cross-functionally to enhance performance and availability of high-traffic systems, driving innovation in a dyna...
6 days ago
Director Strategy for Advanced Networking and Enterprise
$156K - $215K *
Empower innovation in advanced networking and enterprise solutions by defining strategic roadmaps and driving product lifecycle planning across high-speed networking, optical technologies, and AI plat...
6 days ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.