Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$150K - $180K *

Shape and execute a comprehensive partnership strategy to drive growth, enhance market presence, and foster high-value alliances across the healthcare ecosystem, collaborating with executive leadershi...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Champion transformative initiatives by translating priorities into actionable plans, coordinating cross-functional teams, and driving organizational change to enhance operational effectiveness and ado...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $140K *

Lead the charge in driving sales for mid-sized public safety agencies, managing full-cycle deals from opportunity identification to closing. Collaborate with cross-functional teams to ensure successfu...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$106K - $167K *

Join us to analyze and optimize complex business processes, design ERP solutions, and lead integration efforts. Collaborate with teams to enhance performance and ensure compliance while delivering hig...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $190K *

Pioneer innovative AI solutions to transform biomedical discovery, collaborating with top scientists and engineers to bridge virtual and real-world data, enhancing drug discovery and clinical care pro...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Help us deliver exceptional training and support for medical imaging equipment, enhancing customer experiences through expertise and mentorship while traveling frequently to engage with healthcare pro...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $102K *

Join a team that's transforming ERP solutions by customizing and integrating systems to meet business needs. Collaborate with stakeholders to enhance performance and ensure compliance while delivering...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Drive AI-powered marketing initiatives to optimize campaigns, enhance pipeline generation, and leverage automation. Collaborate cross-functionally while experimenting with emerging technologies to red...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$130K - $150K *

Unlock potential by leading the design and integration of secure, resilient network architectures for mission-critical systems, ensuring operational performance and recovery objectives are met through...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $120K *

Shape the future of data-driven decision-making by developing innovative data products and AI solutions. Collaborate with cross-functional teams to deliver impactful analytics and automation tools tha...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$97K - $151K *

Lead the growth of agency relationships to enhance profitability in your territory. Oversee the execution of strategic initiatives, manage agent performance, and deliver training to drive success in G...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$92K - $153K *

Join a team that's dedicated to enhancing patient access by managing reimbursement challenges and providing education to healthcare providers. This role requires strong relationship-building skills an...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$190K - $267K *

Drive impactful ad experiences by leveraging your frontend expertise in JavaScript and TypeScript. Collaborate with cross-functional teams to enhance user engagement and optimize ad performance across...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Media

$81K - $128K *

Unlock potential by shaping integrated corporate communications strategies that connect software innovation with community impact, bridging B2B and B2C narratives to advance fraud prevention and eleva...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$261K - $308K *

Transform Women's Health engineering by leading a high-impact team to deliver innovative software solutions. Collaborate across functions to shape strategy and drive organizational excellence while en...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$113K - $147K *

Pioneer innovative solutions as a Microsoft Power Platform Architect, leading enterprise-grade design and implementation. Collaborate with stakeholders to enhance efficiency, automate processes, and d...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Shape the future of data protection by leading a high-performing team of analysts. Drive incident response, enhance security strategies, and collaborate with clients to mitigate risks in a fast-paced...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Partner with us to shape the future of talent acquisition and employee engagement. Lead strategies that attract, retain, and support exceptional talent while enhancing the employee experience across a...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Shape the future of partner marketing by building and executing joint plans with key resellers and distributors, driving engagement and pipeline growth through innovative campaigns and strategic commu...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Unlock your potential as a Senior Applied AI Engineer, leading teams to design and deliver impactful AI solutions. Drive technical excellence and mentor engineers while shaping the future of AI system...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Transform healthcare data products by leading strategy, execution, and cross-functional collaboration. Drive product-market fit and commercialization for API-based solutions, ensuring alignment with c...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Transform procurement operations by leading strategy and team management in a regulated manufacturing environment. Drive supplier performance, cost efficiency, and material availability to support pro...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Staffing

$466K - $500K+*

Unlock potential by developing scalable AI/ML model serving infrastructure. Collaborate cross-functionally to enhance performance and availability of high-traffic systems, driving innovation in a dyna...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$156K - $215K *

Empower innovation in advanced networking and enterprise solutions by defining strategic roadmaps and driving product lifecycle planning across high-speed networking, optical technologies, and AI plat...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.