Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,580

Sort By: Relevance

$113K - $254K *

Drive innovation by developing scalable Python services and AI-driven solutions. Collaborate with data science teams to enhance pricing automation and improve operational efficiency in a fully remote...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Transportation

$132K - $170K *

Transform client relationships and drive growth by consulting with C-level executives to implement strategic solutions that enhance value and satisfaction across major accounts, ensuring retention and...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Business Services

$172K - $202K *

Lead the charge in delivering innovative insights and strategies for clients, leveraging in-depth market analysis and research expertise to address complex challenges and drive actionable results for...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Business Services

$120K - $145K *

Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$180K - $220K *

Lead the sales strategy for a healthcare Payer business unit, driving market penetration, revenue growth, and client satisfaction. Collaborate with leadership to shape go-to-market strategies and buil...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$187K - $220K *

Transform product marketing by shaping positioning, launching AI features, and driving go-to-market strategies. Collaborate with cross-functional teams to influence product direction and execute impac...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $145K *

Shape the future of energy efficiency by leading complex client programs and strategic initiatives. Drive portfolio success through operational excellence, financial performance, and strong client rel...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$80K - $120K *

Join a mission-driven team as an Account Executive, where you'll engage with K-12 district leaders, build partnerships, and drive sales to improve outcomes for English learners across a diverse territ...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$145K - $165K *

Drive impactful clinical research strategies by collaborating with cross-functional teams, analyzing data, and disseminating findings through publications and presentations. Elevate your career while...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Drive the pre-execution contract lifecycle for pharmacy and medical benefits, ensuring clear agreements and timely completion. Collaborate with cross-functional teams to enhance contracting processes...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $200K *

Accelerate sales growth by managing key partnerships and driving cloud solutions. Collaborate with teams to achieve targets, nurture relationships, and deliver exceptional customer experiences while s...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$124K - $236K *

Reimagine your career by leading a dynamic team in financial advisory. Drive impactful projects with finance executives, enhance reporting processes, and foster client relationships while developing j...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$145K - $193K *

Transform the marketing data landscape by leading the architecture and evolution of a scalable data platform. Drive innovation in analytics, AI, and operational frameworks to enhance marketing strateg...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$158K - $190K *

Shape the future of medical device marketing by leading strategic initiatives for the Americas peripheral and closure portfolios. Drive growth, oversee major product launches, and collaborate with cro...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by driving growth in IVIG and specialty infusion services. Build strong provider relationships, educate on treatment options, and collaborate with healthcare teams to enhance patient...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Join a team that advances occupational safety management across projects by implementing and overseeing comprehensive safety policies. Collaborate with cross-functional teams to ensure compliance with...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$73K - $102K *

Join a team that's shaping innovative SAP solutions. Leverage your expertise in ABAP and Fiori to drive impactful projects, enhance client experiences, and contribute to a dynamic consulting environme...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Transform the future of marketing by designing and deploying AI-driven growth systems. This hands-on role merges engineering and marketing to enhance customer engagement and streamline operations thro...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$88K - $154K *

Champion the successful execution of field projects, ensuring adherence to budget, timeline, and quality standards while leading teams and coordinating with stakeholders in a dynamic environment...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$88K - $154K *

Transform your career by leading full-lifecycle recruiting for federal proposals, focusing on defense and intelligence sectors. Collaborate with teams to develop strategies, source talent, and ensure...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Elevate project success by managing costs for complex Life Sciences construction initiatives. Collaborate with multidisciplinary teams, ensuring client objectives are met through effective cost manage...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Join a team that's dedicated to delivering exceptional tax services while fostering client relationships. Leverage your expertise in public accounting to manage multiple engagements and grow within a...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$95K - $115K *

Shape the future of tax services by leading client engagements, mentoring teams, and delivering exceptional service. Leverage your expertise in a collaborative environment to drive growth for privatel...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$94K - $151K *

Unlock potential by driving the design and maintenance of IT storage solutions. Collaborate with cross-functional teams to enhance system performance and reliability, ensuring alignment with enterpris...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Elevate the security landscape by leading identity governance and workforce protection initiatives. Drive strategic direction, oversee technical teams, and ensure compliance while enhancing identity s...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.