Discover professional opportunities across California with Ladders. From established business centers to growing regional economies, the state offers senior-level roles in technology, healthcare, finance, entertainment, manufacturing, and more. Browse vetted job listings with salaries of $100,000 or higher and find positions that align with your experience and career goals.
California’s diverse economy supports leadership and specialized roles at companies of all sizes. Depending on your background, you may find opportunities in software and technology, life sciences, healthcare, financial services, clean energy, media, aerospace, and professional services. Job availability and compensation vary by role, employer, and location.
Explore openings in major employment centers such as Los Angeles, San Francisco, San Diego, San Jose, Sacramento, and surrounding communities. Listings may include on-site, hybrid, and remote arrangements; review each posting for its work location and requirements.
Use Ladders to focus your search on vetted professional jobs paying $100,000 or more. Review role responsibilities, qualifications, compensation details, and workplace expectations, then apply directly to opportunities that fit your goals. Keep your profile and resume current so employers can better understand your experience.
HR Process Improvement Specialist
$97K - $145K *
Join us to enhance operational efficiency and drive process improvements across departments. As a senior specialist, you'll lead initiatives that streamline workflows, implement automation, and elevat...
Reposted 2 weeks ago
Medical Director, Clinical Informatics, Pathology
$2K - $500K+*
Transform healthcare delivery by leading clinical informatics initiatives that enhance patient outcomes through strategic digital technology adoption and optimization. Collaborate with diverse teams t...
3 weeks ago
Senior Marketing Performance Analyst
$132K - $165K *
Transform marketing performance through data-driven insights and collaboration. Partner with cross-functional teams to analyze campaigns, optimize strategies, and mentor junior analysts, driving impac...
3 days ago
$80K - $95K *
Transform patient care by providing specialized nursing services in North County. Enjoy flexible hours and the opportunity to work close to home while conducting comprehensive assessments and supporti...
5 days ago
$85K - $100K *
Transform patient care by providing safe, effective support in a dynamic healthcare environment. Collaborate with a team to assess, plan, and implement treatment strategies while ensuring adherence to...
3 weeks ago
$85K - $100K *
Drive exceptional patient care through effective assessment, intervention, and education. Collaborate with healthcare teams to fulfill organizational standards and enhance patient outcomes. Integrate...
4 weeks ago
$100K - $120K *
Support clinical studies by assisting teams with tasks like medical monitoring and protocol management. Collaborate across functions and engage with stakeholders to ensure successful trial outcomes wh...
3 weeks ago
$100K - $120K *
Drive evidence-based healthcare improvements by leading evaluations and strategic analyses. Collaborate with multidisciplinary teams to enhance Military Health System outcomes through expert consultat...
3 weeks ago
Associate Director - Clinical Operations - Healthcare
$155K - $259K *
Elevate your career by leading integrated optimization programs that enhance clinical, operational, and financial performance for healthcare clients. Drive measurable outcomes while managing diverse m...
Reposted 2 weeks ago
$74K - $108K *
Join a team that's dedicated to optimizing patient care through effective managed care strategies. You'll advocate for clients, collaborate with multidisciplinary teams, and enhance relationships with...
2 weeks ago
$160K - $200K *
Build high-impact AI/ML features and robust backend systems, demonstrating exceptional coding skills while mentoring engineers. Lead technical architecture and ensure software meets regulatory standar...
3 weeks ago
$100K - $120K *
Grow your career with a leadership role that enhances patient care and manages a dynamic team in Oncology Infusion. Oversee operations, staff development, and quality assurance to ensure efficient, co...
3 weeks ago
Sr. Healthcare Data Scientist (Medicare/Medicaid)
$85K - $115K *
Lead advanced analytics initiatives to detect and prevent fraud in Medicare and Medicaid, leveraging expertise in data science and machine learning to drive impactful solutions alongside a team of pro...
4 weeks ago
Solutions and Services Architect
$85K - $118K *
Innovate the pharmacy landscape by architecting comprehensive TPA solutions, transforming complex requirements into streamlined operations, and enhancing client outcomes through strategic PBM partners...
3 weeks ago
$89K - $110K *
Grow your career with a dynamic team providing home and community care. Leverage your nursing expertise in an interdisciplinary setting to ensure quality outcomes, effectively communicate with clients...
3 weeks ago
$89K - $110K *
Shape the future of patient care by joining an interdisciplinary team focused on delivering high-quality home and community services. Utilize your nursing skills to assess needs, improve outcomes, and...
3 weeks ago
$89K - $110K *
Engage with an interdisciplinary care management team to enhance client care. Review medical records, track quality indicators, conduct visits and collaborate on client treatment for optimal outcomes...
3 weeks ago
IT Enterprise Applications Analyst
$73K - $103K *
Lead the charge in managing bank applications ensuring top availability, performance, and security. Collaborate with diverse teams to troubleshoot issues, enhance systems, and maintain compliance with...
Reposted 3 weeks ago
$126K - $189K *
Join a team that's leading provider enrollment operations, ensuring timely onboarding, compliance, and accuracy. Drive strategic initiatives and enhance operational efficiency across networks while co...
3 weeks ago
$215K - $250K *
Unlock potential by leading advanced operations research for space sensing missions. Drive quantitative analyses and modeling efforts that shape U.S. Space Force strategies and capability decisions fo...
Reposted 2 weeks ago
$140K - $190K *
Join a team that's transforming clinical trials through advanced data science. Drive the development of predictive models and machine learning algorithms to enhance patient enrollment and trial manage...
2 weeks ago
Analyst I/II-Homelessness Response Division- Housing Department
$92K - $123K *
Empower the community by coordinating shelter placements and enhancing data management in the Homelessness Response Division. Collaborate with partners to streamline services and improve outcomes for...
1 week ago
Registered Nurse - Home Health
$118K - $135K *
Transform the future of patient care as a Home Health RN Case Manager. Utilize your clinical expertise to develop and implement comprehensive care plans, collaborating with families and interdisciplin...
Reposted 5 days ago
Registered Nurse - Home Health
$118K - $135K *
Join a team that crafts comprehensive care plans for patients at home, enhancing wellness and reducing hospital visits through skilled assessments, education, and interdisciplinary collaboration in a...
Reposted 5 days ago
Registered Nurse - Home Health
$118K - $135K *
Join a dynamic team and lead innovative home health care solutions, ensuring optimal patient wellness and seamless care management while collaborating with interdisciplinary teams in a supportive and...
Reposted 5 days ago
What types of $100,000+ jobs can I find in California?
California listings may include senior and specialized roles in technology, healthcare, finance, life sciences, entertainment, clean energy, manufacturing, and other fields. Available positions depend on current employer needs.
Where in California can I search for jobs?
You can explore opportunities across the state, including major employment hubs such as Los Angeles, San Francisco, San Diego, San Jose, and Sacramento. Check each posting for its specific location and work arrangement.
Are all jobs on this page guaranteed to pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review each listing for compensation information and details, since pay can vary by position and employer.
Can I find remote or hybrid California jobs?
Some listings may offer remote or hybrid work, while others require on-site work. The job posting provides the employer’s location and work arrangement requirements.
How can I improve my California job search?
Narrow your search by role, location, industry, and work arrangement. Keep your resume and profile updated, and carefully compare each opportunity’s qualifications and compensation details.