Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$85K - $95K *

Unlock potential by leading business analysis to transform processes into actionable requirements for a major financial management system. Collaborate with stakeholders to enhance workflows and ensure...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$177K - $338K *

Champion DMPK project leadership by ensuring high-quality data delivery and supporting drug candidate progression through innovative modeling and cross-functional collaboration in a dynamic biotech en...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Engage with patients as a Virtually Integrated Care RN, providing essential remote support and care coordination. Utilize advanced clinical skills to assess needs, develop care plans, and enhance pati...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$190K - $210K *

Unlock data-driven insights as a hybrid leader, balancing hands-on analytics with high-level client strategy. Drive impactful initiatives and foster cross-functional collaboration to deliver valuable...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $160K *

Analyze complex data and drive solutions as a Business Analyst in the public sector. Leverage your expertise in pension systems to identify issues and enhance processes, ensuring effective communicati...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $160K *

Empower the development of mission-critical applications on the ServiceNow platform, collaborating with stakeholders to deliver scalable solutions while ensuring compliance with federal standards and...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $230K *

Grow your career with a dynamic role that drives oncology product success, builds key relationships, and enhances patient access through strategic engagement and innovative solutions in a competitive...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock potential by providing in-home occupational therapy services, evaluating safety, assessing functional needs, and implementing personalized treatment plans to enhance patient independence and qu...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$140K - $180K *

Join a team that's dedicated to developing scalable software solutions, designing responsive UIs, and optimizing backend services. Collaborate across functions to drive innovation and champion best pr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$215K - $289K *

Lead the charge in driving legal strategy and contract negotiations across all business units, ensuring compliance and supporting revenue growth through effective collaboration with sales, finance, an...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $160K *

Champion the design and implementation of scalable data pipelines, ensuring data integrity and availability. Collaborate with cross-functional teams to optimize data workflows and enhance infrastructu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Engineer innovative fraud detection models and features to identify high-risk activities while ensuring a seamless experience for legitimate customers. Collaborate with teams to translate insights int...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Join a team that's dedicated to delivering successful projects on time and on budget. As a key player, you'll drive project planning, coordinate with stakeholders, and ensure effective communication t...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$82K - $182K *

Analyze healthcare costs and quality outcomes to drive value-based care strategies, collaborating with clinical and financial teams. Lead data-driven insights and financial modeling to enhance operati...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$84K - $131K *

Engineer innovative web applications by leveraging Java and Spring Boot. Collaborate across teams to implement DevSecOps practices, ensuring secure, efficient delivery while integrating AI capabilitie...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Drive client engagement and solution development in digital banking, leveraging expertise in banking technology and pre-sales. Collaborate with teams to deliver tailored solutions and impactful demons...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$136K - $171K *

Pioneer clinical trial excellence by leading operational planning and execution. Collaborate cross-functionally to ensure compliance, quality, and timely delivery of clinical studies while mentoring j...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$101K - $136K *

Transform clinical documentation by crafting high-quality regulatory submissions. Collaborate with cross-functional teams to ensure compliance with FDA and ICH guidelines while managing timelines and...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive the development of high-quality regulatory and clinical documents, leading medical writing efforts and collaborating with cross-functional teams to ensure accuracy, clarity, and compliance with...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Drive the planning and execution of complex therapeutic programs from discovery to clinic. Serve as a senior program management partner, ensuring successful execution and alignment across cross-functi...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $170K *

Take ownership of strategic finance leadership, optimizing cash flow and credit risk while developing innovative financing solutions to drive profitable growth and enhance operational efficiency acros...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$199K - $269K *

Grow your career with a leadership role in AI Digital Product Management, driving strategy and innovation across a portfolio of AI products. Collaborate with cross-functional teams to deliver scalable...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$96K - $120K *

Partner with cross-functional teams to drive successful integrations, ensuring best practices and client satisfaction. Become the internal expert on data management while leading technical relationshi...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Elevate project delivery by leading cross-functional teams in Interactive Response Technology, ensuring client satisfaction and timely execution while managing risks and fostering continuous improveme...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$87K - $131K *

Join a team that's dedicated to delivering exceptional patient care while overseeing nursing staff and collaborating with healthcare professionals to enhance service quality and operational efficiency...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.