Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Managing Director, Go-to-Market Value Creation
$210K - $250K *
Drive portfolio value creation through strategy execution, leveraging your extensive experience in revenue growth and go-to-market capabilities to lead engagements and mentor GTM teams across technolo...
Reposted 2 weeks ago
Senior Consultant – Federal Grants Monitoring and Program Integrity
$98K - $163K *
Analyze and support federal clients in oversight and monitoring of grant programs, ensuring program integrity and accountability. Collaborate with stakeholders to assess risks, develop recommendations...
Yesterday
Senior Quality Operations Specialist, Audit
$74K - $98K *
Champion regulatory audit excellence by leading PACE audits, ensuring compliance, and driving cross-functional collaboration to enhance operational readiness and continuous improvement across the orga...
3 weeks ago
$150K - $180K *
Lead the charge in transforming finance operations through strategic planning and execution. Build and scale the finance function for a high-growth startup, ensuring resources align with growth initia...
Reposted 4 weeks ago
$190K - $230K *
Lead the accounting and financial reporting functions within a growing healthcare organization. Drive integrity across multiple entities, ensure compliance, and strategize cash management while suppor...
Reposted yesterday
Director Commercial Compliance
$119K - $186K *
Lead the development of a risk-based compliance framework for U.S. pharmaceutical commercialization, advising senior leaders and ensuring adherence to compliance standards while fostering ethical deci...
2 weeks ago
Yourgi Senior Manager of Engineering Services
$190K *
Optimize engineering services by leading DevOps and SRE teams, enhancing CI/CD processes, and ensuring data governance. Drive operational excellence and security while fostering a collaborative enviro...
1 week ago
Senior Solutions Consultant - Risk Adjustment
$142K - $177K *
Champion innovative risk adjustment solutions by leveraging deep expertise to enhance payer and provider strategies. Collaborate with cross-functional teams to deliver impactful presentations and driv...
1 week ago
Director, Medical Digital Solutions
$192K - $252K *
Champion digital transformation by optimizing medical technology solutions and enhancing HCP engagement strategies. Drive adoption and value realization of innovative tools across Field Medical teams...
2 weeks ago
Senior Scientific Director (Virology)
$150K - $180K *
Lead the charge in developing and overseeing scientific content across multiple therapeutic areas, ensuring high-quality contributions and strategic client interactions to drive growth and innovation...
4 weeks ago
Senior Decision Support Analyst
$71K - $112K *
Drive impactful financial and operational analysis to enhance performance. Collaborate with stakeholders, mentor junior analysts, and present insights that inform strategic decisions across the organi...
1 week ago
Client Success Executive - Prescription Benefits
$80K - $95K *
Drive client success by leading strategic account teams, ensuring satisfaction, and fostering strong relationships. Leverage expertise to enhance service delivery and support client retention through...
Reposted 2 days ago
Complaints/Referrals Team Lead - Medicare
$66K - $106K *
Elevate your career by leading a dynamic team focused on investigating and resolving fraud, waste, and abuse. Drive quality objectives, mentor team members, and ensure timely case development while co...
Reposted yesterday
$110K - $130K *
Join a team that's dedicated to driving growth in healthcare accounts. Leverage your strategic sales expertise to build relationships, identify opportunities, and deliver value in a fast-paced environ...
Yesterday
Proposal Writer - Federal Government Contracting (GovCon) | Washington, D.C. | Remote
$80K - $95K *
Create compelling, compliant proposals for federal contracts, collaborating with cross-functional teams to translate technical concepts into persuasive narratives that meet government requirements and...
3 weeks ago
Senior Oncology Account Manager, Detroit
$150K - $230K *
Transform the oncology landscape by driving product success and building strong relationships with key stakeholders. Leverage your expertise to enhance patient access and deliver innovative solutions...
1 week ago
$120K - $160K *
Contribute to malaria programming by providing technical leadership and support to country teams, ensuring quality interventions, compliance, and strategic resource investments across health facilitie...
1 week ago
Senior Engineer/Scientist- Epidemiologist
$110K - $130K *
Elevate your career by providing expert epidemiological insights into occupational exposures for military aviation and firefighter data sets, driving impactful research and analysis to enhance safety...
4 weeks ago
$242K - $303K *
Join as the primary privacy leader to manage and enhance an enterprise-wide privacy program while navigating complex regulations. Collaborate across departments to drive compliance, innovation, and ef...
Reposted 4 weeks ago
$150K - $180K *
Shape the future of our platform by leading cross-organizational initiatives, defining architectural standards, and mentoring engineers. Drive technical excellence and influence across teams while own...
3 weeks ago
Head of Business Risk & Controls
$180K - $200K *
Lead the development of a robust risk and control framework, ensuring effective identification and management of risks in fiduciary and regulated financial services. Collaborate with stakeholders to e...
2 weeks ago
Project Manager 2, Patient Monitoring (Northeast and Mid-Atlantic Region)
$85K - $125K *
Collaborate with cross-functional teams to lead large-scale healthcare projects, ensuring timely installation and customer satisfaction. Manage project scope, timelines, and resources while communicat...
Reposted 2 days ago
$95K - $115K *
Unlock potential by driving business growth in the Geo division. Build relationships with engineers and contractors, educate on product offerings, and secure bidding opportunities. Remote work availab...
1 week ago
Senior Oncology Account Manager, Orlando
$150K - $230K *
Drive the promotion of oncology products by building relationships with key stakeholders, exceeding performance goals, and ensuring patient access to therapies while managing territory resources effec...
1 week ago
Sr. Implementation Engineer (MANTL)
$96K - $120K *
Accelerate progress at the forefront of digital banking by leading complex client implementations, resolving advanced technical issues, and ensuring successful delivery of innovative solutions that al...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.