Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$76K - $148K *

Play a key role in managing clinical trials, ensuring compliance and quality oversight of project deliverables while collaborating with cross-functional teams to meet timelines and budget goals...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $220K *

Join a team that's redefining strategic sourcing for commercial categories. Lead initiatives that drive value, enhance supplier performance, and align with business goals while managing vendor relatio...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by leading a remote pharmacy program focused on medication adherence. Collaborate with a specialized team to enhance patient care through data-driven strategies and operational suppor...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $200K *

Manage compliance and regulatory functions for a global SaaS provider, advising on laws impacting enterprise clients. Collaborate cross-functionally to ensure timely compliance and develop best practi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Join a team that's dedicated to identifying and recruiting top-tier leadership talent across various sectors. Engage in full-cycle recruiting or selected stages, leveraging your expertise to connect w...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$155K - $175K *

Serve as a key scientific partner in the field, driving prelaunch and launch strategies through trusted relationships, high-quality exchanges, and actionable insights to enhance product adoption and c...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Manage a portfolio of strategic enterprise clients, fostering executive relationships and driving retention and adoption. Utilize data and AI tools to enhance client value, mentor team members, and sh...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $125K *

Advance your career by coordinating healthcare technology integration across multiple VA sites. Leverage your project management skills to support the Federal Electronic Health Record Modernization pr...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$113K - $188K *

Join a dynamic team to design and develop high-performance ETL solutions, integrating data from diverse sources. Collaborate with cross-functional teams to optimize data workflows and ensure complianc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$246K - $332K *

Transform the future of field operations by leading strategic initiatives that enhance commercial effectiveness and drive measurable impact across customer-facing teams. Collaborate with cross-functio...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$204K - $274K *

Champion the U.S. Biologics Regulatory CMC team by providing strategic leadership, ensuring timely regulatory submissions, and fostering collaboration among global stakeholders to drive innovative bio...

United StatesRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Drive portfolio value creation through strategy execution, leveraging your extensive experience in revenue growth and go-to-market capabilities to lead engagements and mentor GTM teams across technolo...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$98K - $163K *

Analyze and support federal clients in oversight and monitoring of grant programs, ensuring program integrity and accountability. Collaborate with stakeholders to assess risks, develop recommendations...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$74K - $98K *

Champion regulatory audit excellence by leading PACE audits, ensuring compliance, and driving cross-functional collaboration to enhance operational readiness and continuous improvement across the orga...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in transforming finance operations through strategic planning and execution. Build and scale the finance function for a high-growth startup, ensuring resources align with growth initia...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $230K *

Lead the accounting and financial reporting functions within a growing healthcare organization. Drive integrity across multiple entities, ensure compliance, and strategize cash management while suppor...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Healthcare

$119K - $186K *

Lead the development of a risk-based compliance framework for U.S. pharmaceutical commercialization, advising senior leaders and ensuring adherence to compliance standards while fostering ethical deci...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$108K - $114K *

Join a team that's dedicated to enhancing patient care as a Speech Language Pathologist. Collaborate with health professionals in a supportive environment, providing essential therapy services to impr...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$190K *

Optimize engineering services by leading DevOps and SRE teams, enhancing CI/CD processes, and ensuring data governance. Drive operational excellence and security while fostering a collaborative enviro...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$142K - $177K *

Champion innovative risk adjustment solutions by leveraging deep expertise to enhance payer and provider strategies. Collaborate with cross-functional teams to deliver impactful presentations and driv...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$192K - $252K *

Champion digital transformation by optimizing medical technology solutions and enhancing HCP engagement strategies. Drive adoption and value realization of innovative tools across Field Medical teams...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead the charge in developing and overseeing scientific content across multiple therapeutic areas, ensuring high-quality contributions and strategic client interactions to drive growth and innovation...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$71K - $112K *

Drive impactful financial and operational analysis to enhance performance. Collaborate with stakeholders, mentor junior analysts, and present insights that inform strategic decisions across the organi...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive client success by leading strategic account teams, ensuring satisfaction, and fostering strong relationships. Leverage expertise to enhance service delivery and support client retention through...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$66K - $106K *

Elevate your career by leading a dynamic team focused on investigating and resolving fraud, waste, and abuse. Drive quality objectives, mentor team members, and ensure timely case development while co...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.