Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$125K - $150K *
Manage financial operations for a large-scale, multi-source IT services program. Collaborate with enterprise partners and ensure accurate financial reporting, chargebacks, and support for invoicing. E...
Reposted 4 weeks ago
$160K - $200K *
Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...
Today
$170K - $185K *
Join a dynamic team to define and lead product strategy for Family Building Navigation, enhancing member engagement through innovative digital experiences and personalized support while collaborating...
5 days ago
$82K - $139K *
Lead the charge in transforming complex customer agreements into compliant ASC 606 conclusions, ensuring accurate revenue processes while partnering across teams to automate and enhance operational ef...
Reposted 4 weeks ago
Senior Director - Business Finance
$206K - $268K *
Empower operational finance by leading cost-of-revenue functions, serving as a strategic partner to executives and enhancing organizational performance and scalability through effective leadership and...
Reposted 5 days ago
Vice President, Reporting and Data Analytics
$202K - $250K *
Champion data-driven decision-making by leading the development of integrated analytics and reporting strategies. Drive operational efficiency and financial performance through innovative data solutio...
3 days ago
$135K - $160K *
Drive clinical data management excellence by leading strategies, ensuring data integrity, and collaborating across functions to support successful clinical trials and regulatory submissions in a dynam...
Yesterday
$125K - $150K *
Pioneer in radiology innovation by enhancing clinical value and technology. Join a forward-thinking team that prioritizes high-quality patient care while driving improvements in service and operationa...
Reposted 2 weeks ago
Actuarial Manager, Medicare Value-Based Care
$129K - $162K *
Develop and lead actuarial processes for Medicare Value-Based Care, managing monthly results, payer settlements, and special projects. Collaborate with cross-functional teams to enhance analytics and...
2 weeks ago
Revenue Cycle Enterprise Partner
$133K - $191K *
Transform revenue cycle operations by leading strategic initiatives, optimizing performance, and fostering collaboration across business units to enhance service delivery and achieve organizational go...
1 week ago
Revenue Cycle Business Partner II
$78K - $113K *
Unlock potential by leading complex revenue cycle projects, providing analytical support, and collaborating across departments to enhance billing processes and resolve financial issues in a fast-paced...
3 days ago
Director, Technical Products and Operations
$200K - $235K *
Drive product excellence by owning the lifecycle and security of high-performance client SaaS platforms hosted on AWS. Lead a dedicated team to optimize operations, ensure compliance, and deliver seam...
Reposted 1 week ago
Senior Principal, Business Management
$135K - $160K *
Drive strategic initiatives by developing KPI frameworks and operational dashboards, analyzing performance data, and collaborating across teams to enhance business outcomes and support informed decisi...
Today
$160K - $200K *
Drive strategic growth and operational excellence in cardiology, fostering physician partnerships and overseeing clinical and financial performance to enhance patient care and organizational success...
Today
Senior Director, Client Success
$150K - $180K *
Reimagine client partnerships by managing complex relationships, driving performance, and leading recovery strategies. Collaborate with executives to ensure client success and identify growth opportun...
2 weeks ago
Associate Director, Business Improvement
$130K - $160K *
Reimagine business improvement strategies as a senior contributor, leading high-impact initiatives across functions. Drive alignment, governance, and measurable outcomes while influencing stakeholders...
2 weeks ago
Director, Sales Strategy & Value
$150K - $180K *
Unlock potential by driving sales strategy and value analysis, partnering with cross-functional teams to enhance proposals, pricing, and contracts. Lead market research and client engagement to optimi...
2 weeks ago
$170K - $180K *
Transform the sales landscape by leading strategic initiatives that enhance performance management, forecasting, and accountability across the commercial organization, driving profitable growth and ac...
3 weeks ago
Director, Distribution Strategy
$172K - $203K *
Empower the distribution strategy by designing and managing rate content across channels, ensuring accurate delivery and partner trust. Collaborate with cross-functional teams to build scalable progra...
1 week ago
Director, Specialty Clinical Solutions- REMOTE
$143K - $243K *
Champion innovative clinical strategies in specialty pharmacy, overseeing services and solutions to enhance client value and outcomes. Collaborate with cross-functional teams to drive program performa...
3 weeks ago
Director, Sales & Operations Planning
$150K - $180K *
Drive operational excellence by leading the S&OP strategy, aligning resources with business goals, and optimizing capacity planning across the network to enhance efficiency and service delivery...
1 week ago
Snr Director, Global Controller
$160K - $200K *
Lead global accounting functions, ensuring integrity and efficiency in financial processes. Supervise teams across multiple locations while enhancing reporting accuracy and compliance within a growing...
Reposted today
$275K - $350K *
Lead the charge in transforming operations by integrating AI and technology to enhance member and clinician experiences, ensuring efficient care delivery and operational excellence across a distribute...
1 week ago
Director, Commercial Project Management
$201K - $251K *
Join us to lead cross-functional project management in a dynamic biotech environment. Drive global commercialization initiatives, ensuring alignment and execution across teams while enhancing operatio...
2 weeks ago
Senior Manager, Clinical Conduct
$90K - $110K *
Empower cross-functional teams to drive the Future of Medicine initiatives, ensuring scalable processes and compliance while enhancing patient safety and experience through strategic planning and exec...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.