Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$155K - $210K *
Lead complex programs and strategic client engagements, driving technology transformation and sustainable business value. Act as a trusted adviser to C-level stakeholders, shaping program vision and e...
2 weeks ago
General Manager, Multi-Site Pharmacy Operations
$100K - $120K *
Optimize multi-site pharmacy operations by overseeing daily workflows, staffing, and performance metrics. Collaborate with leadership and Pharmacists-in-Charge to ensure compliance and efficiency acro...
2 weeks ago
Associate Director, Drug Product, Pulmovant
$130K - $160K *
Lead the technical direction for inhaled dry powder products, ensuring product performance and manufacturability while collaborating with cross-functional teams to navigate development and regulatory...
2 weeks ago
Director, Capital Formation High Net Worth
$160K - $200K *
Lead the charge in capital formation by raising equity from high-net-worth investors, ensuring timely funding for real estate deals. Build and coach a high-performing team while architecting a vibrant...
6 days ago
Executive Assistant - Bellevue
$93K - $109K *
Innovate alongside executives by providing strategic support to drive organizational success, manage high-stakes priorities, and enhance workflow efficiency. You'll serve as a vital liaison and truste...
Reposted 1 week ago
Account Manager, North America Large Accounts
$173K - $288K *
Empower growth and relationships in a strategic role focused on managing key accounts. Drive customer satisfaction and revenue retention through strategic collaboration and consultative selling within...
Reposted 3 weeks ago
$105K - $130K *
Drive global events strategy and execution, ensuring alignment with GTM priorities to generate measurable business outcomes across the customer lifecycle, from acquisition to retention...
Reposted 3 days ago
$160K - $200K *
Drive the evolution of Sales Operations by designing and optimizing processes, governance, and technology to enhance execution and productivity across the organization, ensuring alignment with strateg...
3 days ago
Senior Director, European Regulatory Strategy Lead
$160K - $259K *
Champion regulatory excellence by leading European strategies for innovative therapies. Drive successful submissions and interactions with health authorities, ensuring compliance and alignment across...
2 weeks ago
Senior Director - BDM - Life Insurance & Annuities
$170K - $200K *
Join us to drive client relationships and business growth, managing complex accounts while ensuring delivery excellence. Collaborate with stakeholders to create strategic account plans and lead new bu...
6 days ago
Trade Compliance Manager, Master Data & Controls
$87K - $139K *
Optimize trade compliance processes by managing master data and ensuring regulatory readiness. Lead cross-functional collaboration to enhance data accuracy and streamline customs operations, driving e...
6 days ago
$150K - $180K *
Pioneer a robust quality function across fulfillment networks, ensuring inventory integrity and process adherence while driving continuous improvement and regulatory compliance in a high-stakes operat...
1 month ago
$83K - $129K *
Lead the charge in advanced compliance activities, ensuring administrative solutions align with laws and regulations. Utilize AI tools to enhance efficiency, guide teams, and deliver scalable complian...
3 weeks ago
Director, Advanced Missions Group - Tactical Communications & Networking
$170K - $185K *
Join a team that's redefining tactical communications and networking strategies for unmanned systems. Leverage your expertise to shape connectivity solutions, ensuring seamless data exchange across jo...
3 weeks ago
$160K - $200K *
Lead the charge in shaping Stedi's litigation strategy, driving affirmative disputes and regulatory actions to protect and expand our operational freedom in the healthcare sector. Collaborate with lea...
3 weeks ago
$144K - $200K *
Lead a national team of Key Account Leaders to drive sales in campus public safety, focusing on recruitment, coaching, and team performance. Shape strategies to enhance sales effectiveness and adapt t...
1 week ago
Project Manager - Power Solutions
$165K - $185K *
Grow your career with us by leading complex electrical power solutions projects. Collaborate with diverse teams to deliver innovative solutions for mission-critical facilities, ensuring projects meet...
3 weeks ago
SSA - Associate Director, AI & Applied Solutions
$140K - $190K *
Lead the charge in applying AI and data science to drive client value. Build prototypes and mentor teams while engaging with clients at all levels. Shape tech strategies, foster innovation, and delive...
Reposted 2 weeks ago
Senior Director, Product Finance
$227K - $280K *
Lead strategic finance initiatives to empower product decisions, driving financial evaluations and business cases for new product lines. Collaborate with C-suite and product teams to optimize resource...
2 weeks ago
Medical Director, General Medicine
$180K - $220K *
Drive clinical excellence by providing medical expertise across therapeutic areas, ensuring safety and integrity in clinical trials. Collaborate with project teams and senior management to enhance cli...
2 weeks ago
$115K - $158K *
Join us in driving strategic sales initiatives and optimizing operational performance. This role requires strong project management and analytical skills to enhance sales effectiveness and support mar...
Yesterday
Director, Technical Program Management
$209K - $239K *
Drive complex technical initiatives and lead multi-year integration strategies to enhance platform capabilities, ensuring alignment with business objectives and fostering a culture of excellence in Te...
4 weeks ago
Program Administration Director
$130K - $216K *
Transform program administration for a large federal services initiative, overseeing workforce planning, financial operations, and compliance. Collaborate with diverse teams to enhance operational eff...
1 week ago
$115K - $130K *
Drive financial success by overseeing BIM project operations, managing budgets, and collaborating with stakeholders to ensure alignment with organizational objectives while delivering comprehensive fi...
Yesterday
Associate Medical Director, Global Safety Physician
$184K - $253K *
Drive global pharmacovigilance efforts by managing safety data, leading clinical development strategies, and collaborating across teams to enhance product safety and efficacy throughout their lifecycl...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.