Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Project Manager, Client Services
$80K - $95K *
Transform eDiscovery management by driving operational excellence, ensuring timely project delivery, and enhancing workflow efficiency. Collaborate with stakeholders to uphold quality standards and fo...
2 weeks ago
Director, Market Growth Strategy, Molecule to Market (CMC)
$185K - $256K *
Join a team that's redefining CMC strategies in life sciences. You'll engage with industry leaders, drive software adoption, and shape market narratives to enhance product lifecycle management and ope...
2 weeks ago
Senior Director, Software Engineering
$145K - $190K *
Lead the charge in designing and optimizing scalable data pipelines using Azure, PySpark, and Airflow. Collaborate with teams to ensure data quality and performance while mentoring engineers and drivi...
1 week ago
$110K - $130K *
Analyze cloud cost optimization challenges, partnering with customers to enhance FinOps services. Work closely with sales and product teams, utilizing deep Azure expertise to drive actionable insights...
Reposted 2 weeks ago
Sr. Staff Attorney (Regulatory)
$142K - $177K *
Lead legal initiatives by drafting documents, managing records, and providing counsel. Collaborate with executives to shape organizational direction while ensuring compliance and supporting continuous...
Today
$135K - $160K *
Lead the charge in defining user experience strategy, managing a multi-disciplinary design team to deliver innovative, user-centered digital products while fostering collaboration and high-impact desi...
2 weeks ago
Senior Director, Employer Program Management (P5), Lilly Employer
$166K - $244K *
Join a dynamic team to lead the Employer PMO, driving strategic program delivery and cross-functional alignment while enhancing operational efficiency and leveraging modern tools for impactful outcome...
2 days ago
Program Manager, Enterprise Growth & Capital Programs
$100K - $180K *
Lead the charge in delivering enterprise-level growth programs by ensuring alignment across all functions, driving planning and execution adherence, and managing complex initiatives for timely product...
Reposted 2 weeks ago
Operations Standards Manager (Remote)
$80K - $95K *
Drive operational excellence by developing and maintaining standards, ensuring consistency across markets, and collaborating with cross-functional teams to enhance processes and documentation for opti...
1 week ago
Director, Customer Success Onboarding
$120K - $145K *
Lead the onboarding function for diverse customer segments, managing a team to ensure a seamless transition from contract to go-live. Collaborate cross-functionally to enhance processes and drive cust...
2 weeks ago
Assoc Dir, Neuro Thought Leader Liaison (West region)
$190K - $225K *
Empower commercial strategies by building relationships with key thought leaders in rare neurological diseases, capturing insights to inform brand development and launch planning, and ensuring impactf...
Reposted 2 days ago
Group Director, Consumer Services
$150K - $180K *
Join a dynamic team as a senior leader, driving client relationships and revenue growth in lead-generation sectors. You'll manage a diverse portfolio, ensuring lead quality and speed while leveraging...
6 days ago
Deal Advisory Senior Associate
$95K - $140K *
Drive impactful financial due diligence for M&A activities, collaborating with clients and executives to assess enterprise value and risks. Join a high-performing team dedicated to excellence in deal...
Today
$150K - $180K *
Manage financial planning and performance analysis for the GTM organization, partnering with leadership across Sales, Marketing, and Customer Success to drive revenue growth and profitability through...
4 weeks ago
Healthcare IT Technical Operations Lead (Edifecs)
$90K - $120K *
Optimize operational excellence in healthcare IT by managing production support, driving issue resolution, and ensuring timely reporting for customer-facing technology delivery...
2 weeks ago
Senior Legal Analyst & Litigation Project Manager
$92K - $124K *
Partner with us to enhance legal operations and implement eDiscovery processes. You'll lead customer data privacy initiatives, improving cross-functional collaboration and response strategies for comp...
Reposted 4 weeks ago
$140K - $160K *
Engage with senior leaders and drive enterprise sales in the scientific sector. Own pipeline generation and foster relationships while leading complex sales cycles. Shape commercial proposals that bri...
4 weeks ago
$177K - $243K *
Advance your career by leading a global compensation function, shaping strategies, and building a high-performing team. Collaborate with key stakeholders to drive compensation programs that align with...
3 weeks ago
$90K - $125K *
Lead the development and submission of federal proposals, managing teams and resources to deliver compliant, compelling responses. Collaborate with cross-functional teams to ensure alignment with cust...
Yesterday
Lead Advisor, Commissioning & Assurance
$131K - $196K *
Architect and lead the commissioning process for cutting-edge liquid-cooled and AI factory deployments. Ensure rigorous testing and validation, providing independent assurance on performance and desig...
4 weeks ago
$85K - $100K *
Elevate healthcare interoperability by designing and supporting MEDITECH interfaces. Collaborate with teams to enhance data exchange, improve patient care, and ensure seamless integration across syste...
3 weeks ago
Scrum Master/Project Manager II, Technical Project Management
$95K - $115K *
Champion project success by managing SAP OTC enhancement initiatives, ensuring effective planning, stakeholder engagement, and delivery across Agile and Waterfall methodologies while driving continuou...
2 days ago
Business Development Director, DOE
$157K - $283K *
Lead the charge in driving business growth by developing strategic partnerships and innovative solutions for federal clients, while collaborating with cross-functional teams to deliver exceptional res...
1 week ago
Program Manager, Materials Planning
$137K - $185K *
Elevate procurement strategies by analyzing supplier performance and collaborating cross-functionally to ensure material availability and operational efficiency, driving continuous improvement in supp...
Reposted today
Lead Information Security Engineer
$139K - $250K *
Shape the future of cybersecurity by designing secure architectures and leading initiatives to protect systems and infrastructure. Drive improvements in security posture while collaborating with teams...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.