Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Director, Partnership Sales
$140K - $160K *
Drive new business growth by leveraging your expertise in partnership sales, integrated marketing, and sponsorships. Collaborate with brands and agencies to create compelling solutions that meet their...
2 weeks ago
Director, Account Management & Partnerships
$120K - $150K *
Lead the charge in managing client and media partner relationships, ensuring exceptional service and effective contract management while driving growth and collaboration in news media investments...
4 weeks ago
$220K - $260K *
Transform your career by leading product strategy and execution for payment solutions. Drive innovation in payment workflows, enhance reliability, and optimize operational efficiency while collaborati...
2 weeks ago
Market Development Director (Health Systems - Southeast)
$125K - $150K *
Join a team that's transforming healthcare by driving enterprise sales and partnerships with leading health systems. Leverage your expertise to educate executives on innovative solutions that enhance...
Yesterday
Senior Account Manager - Central
$85K - $95K *
Join a dynamic team to deliver exceptional client service, manage accounts, and enhance relationships with AmLaw firms. Drive success through proactive communication, issue resolution, and a client-fi...
2 weeks ago
$160K - $185K *
Join a team that's redefining the SaaS landscape by driving strategic growth and closing high-value deals. Engage with senior leaders, develop a robust pipeline, and collaborate cross-functionally to...
3 days ago
Account Executive, Corporate Accounts, Pacific Northwest Territory
$100K - $120K *
Champion growth by managing corporate healthcare accounts, crafting strategies, and fostering executive relationships to drive revenue and client satisfaction while navigating multi-stakeholder enviro...
1 month ago
Director- Allied Health Programs
$80K - $90K *
Elevate healthcare education by leading the development of innovative allied health programs. Drive growth and improvement through strategic partnerships, curriculum design, and compliance, ensuring l...
3 weeks ago
Account Executive (AutoQuotes)
$135K - $200K *
Engage as a pivotal Account Executive to drive sales growth in the foodservice manufacturing sector. Manage full sales cycles, leverage AI tools, and build strong relationships with C-suite stakeholde...
4 weeks ago
$138K - $198K *
Innovate financial strategies as a key partner in FP&A, driving insights and accountability across R&D and G&A. Own financial models, forecasts, and planning processes to support strategic decision-ma...
2 weeks ago
Director, GTM Planning & Compensation
$207K - $311K *
Shape the future of our global GTM strategy by leading capacity planning, territory design, and incentive structures, driving growth and operational excellence across Sales and Customer Success framew...
4 weeks ago
Director, Global Executive & Strategic Recruiting
$145K - $270K *
Elevate your career by leading global executive recruiting efforts, shaping talent strategies, and building high-performing teams. Drive impactful searches and foster relationships with senior leaders...
2 days ago
Manager, Digital Marketing Operations
$86K - $110K *
Take ownership of digital marketing operations, managing CRM campaigns and creative processes. Collaborate across teams to enhance performance, streamline workflows, and leverage AI for improved resul...
Yesterday
$76K - $148K *
Play a key role in managing clinical trials, ensuring compliance and quality oversight of project deliverables while collaborating with cross-functional teams to meet timelines and budget goals...
Reposted 1 week ago
Manager, Engineering Services Project Management
$110K - $130K *
Lead the charge in managing diverse capital improvement projects across facilities. Oversee planning, execution, and compliance to ensure safe, efficient delivery while minimizing operational disrupti...
Reposted today
Senior Product Manager, Consumer
$120K - $145K *
Empower consumer experiences by leading product strategy and execution for innovative genomics solutions. Collaborate with cross-functional teams to enhance user satisfaction and drive adoption throug...
1 week ago
Manager, Sourcing (Technology)
$100K - $120K *
Champion best practices in vendor management with a focus on strategic sourcing, risk mitigation, and client relationship cultivation to drive operational excellence and maximum value across client en...
Reposted 3 weeks ago
Account Manager, Enterprise Partnerships & Licensing
$95K - $105K *
Elevate client relationships by managing post-sale engagements, ensuring project success, and driving account growth. Collaborate with internal teams to deliver value and strengthen partnerships acros...
2 weeks ago
Environmental Services Manager
$85K - $95K *
Transform environmental compliance in supply chain services by managing assessments, audits, and training. Collaborate with stakeholders to ensure adherence to regulations and enhance operational effi...
2 weeks ago
$172K - $237K *
Unlock potential by leading a dynamic team in security operations. Enhance our AI security strategy and respond to incidents, while ensuring robust protection of endpoints, SaaS, and infrastructure ag...
Reposted 4 weeks ago
$100K - $110K *
Transform business opportunities within the public transit sector by leading complex sales cycles and fostering relationships with government agencies to drive growth and implement tailored software s...
Reposted 1 week ago
U.S. Director of Medical Affairs (US DMA) - Ophthalmology
$190K - $300K *
Transform medical affairs by driving scientific excellence and strategic initiatives in ophthalmology. Collaborate with cross-functional teams to enhance field readiness and optimize engagement across...
1 week ago
Finance Partner Senior, Geisinger Health Plan (Eastern Standard Time Zone resident)
$95K - $115K *
Transform financial operations by providing strategic support to business units, leading forecasting, and enhancing financial performance through collaboration and mentorship. Drive initiatives that p...
5 days ago
Senior Counsel, Commercial Transactions
$145K - $175K *
Lead commercial legal initiatives by providing strategic counsel, drafting agreements, and collaborating with cross-functional teams to drive business objectives while managing legal risks effectively...
Today
$80K - $95K *
Transform the Funding Department by leading a dedicated team, ensuring compliance with policies, optimizing processes, and fostering professional development to achieve high-quality funding approvals...
6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.