Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Revenue Cycle Jobs in South Dakota

Sort By: Relevance

$189K - $256K *

Join a global team to shape regulatory strategies in biotechnology, supporting product development and lifecycle management in Inflammation and Rare Diseases. Lead regulatory efforts, ensure complianc...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Help us manage diverse projects that drive strategic growth and collaboration across teams. As a key member of the EPMO, you'll ensure project success through effective stakeholder management and cont...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$111K - $160K *

Transform category growth by leveraging insights and strategies to enhance customer performance. Collaborate cross-functionally to optimize assortments and drive sales initiatives across diverse retai...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$135K - $185K *

Transform data into actionable insights by enhancing financial models, optimizing sales performance, and driving operational efficiencies. Collaborate with cross-functional teams to support strategic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$90K - $100K *

Accelerate progress at a dynamic agency by leading complex client campaigns. Manage project scope, timelines, and budgets while collaborating with cross-functional teams to deliver high-quality result...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$121K - $161K *

Transform your career by leading the design and implementation of Veeva Vault RIM, ensuring optimal performance and compliance while collaborating with cross-functional teams to enhance user experienc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $352K *

Shape the future of marketing compliance by leading automation initiatives, overseeing review processes, and driving collaboration across teams. This hands-on role combines strategic oversight with di...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$128K - $178K *

Lead the charge in shaping the future of destination marketing through data-driven insights and innovative product strategies. Collaborate with cross-functional teams to enhance customer experiences a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Empower growth by leading SOX and MAR compliance programs, overseeing consultants, and implementing a scalable control environment. Drive governance and quality oversight while collaborating with inte...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Drive product strategy and execution for a critical portfolio area, leading cross-functional teams to transform user insights into impactful software solutions while mentoring others and shaping platf...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$81K - $142K *

Lead the design and development of enterprise data management solutions, collaborating with stakeholders to analyze requirements and enhance data processing capabilities using advanced technologies in...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$102K - $170K *

Accelerate progress at transforming data solutions by building production-grade assets. Leverage your expertise in data engineering and business fluency to create trusted, reusable data products that...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$102K - $170K *

Engage in building production-grade data solutions by transforming architectural designs into trusted data products. Collaborate with cross-functional teams to ensure quality and governance while deli...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Partner with us to drive revenue growth and strategic account management across a diverse portfolio. You'll own the full sales cycle, collaborate with cross-functional teams, and build lasting relatio...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Champion innovations in Risk Operations by optimizing processes and integrating automation. Collaborate with cross-functional teams to enhance efficiency and drive measurable improvements in operation...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$280K - $340K *

Transform regulatory strategy and operations across CMC and clinical activities, leading a high-performing team to ensure compliance and successful product approvals from development through post-appr...

United StatesRemote

3 weeks ago

  •   15+ years exp.  •   Information Technology

$85K - $111K *

Drive the claims module for health care projects, providing domain expertise and analysis. Collaborate with teams to ensure quality processes, meet customer expectations, and assist in implementation...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$100K - $120K *

Shape the future of clinical documentation integrity by leading audits and compliance initiatives across facilities. Collaborate with healthcare teams to enhance operational efficiency and ensure adhe...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$204K - $276K *

Lead the charge in global observational research, driving clinical operational strategy and execution. Collaborate with cross-functional teams to ensure quality and efficiency in evidence generation t...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Join a dynamic team as you lead corporate accounting operations, driving financial reporting, audits, and process improvements. Shape the future of accounting through strategic leadership and innovati...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$122K - $182K *

Unlock potential by leading enterprise-scale data and AI solutions, modernizing actuarial processes, and driving cloud-native transformations. Collaborate with stakeholders to enhance decision-making...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $121K *

Champion legal operations excellence by driving process improvements, metrics establishment, and AI integration to enhance workflow efficiencies and support the Legal team in dynamic, fast-paced envir...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $175K *

Join a team that's driving transformation in insurance technology by leading complex SaaS programs. You'll ensure delivery excellence, manage risks, and enhance client confidence while shaping the fut...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $200K *

Unlock potential by leading high-performing teams in construction disputes and advisory. Drive client relationships, innovate solutions, and ensure quality execution while fostering growth and collabo...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$120K - $140K *

Transform your career by leading product development initiatives that enhance enterprise reporting and analytics. Collaborate with cross-functional teams to deliver high-quality solutions that meet bu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.