Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Quality Operations Specialist, CAP & Monitoring
$74K - $98K *
Elevate quality operations by leading corrective action plans (CAPs) for regulatory compliance. Collaborate with cross-functional teams to drive accountability, resolve barriers, and ensure sustained...
3 weeks ago
Senior Accounting Manager - Insurance
$160K - $180K *
Provide oversight for insurance accounting and reporting, driving process improvements and leveraging technology to enhance financial operations. Collaborate with teams to ensure compliance and accura...
3 weeks ago
Physician Relations Team Manager
$106K - $167K *
Shape the future of physician relations by leading a dynamic team focused on enhancing patient acquisition and optimizing outreach strategies through data-driven insights and performance metrics...
2 days ago
Associate Director, Enterprise Information Architecture
$143K - $193K *
Accelerate progress at the forefront of data-driven transformation in life sciences. Collaborate with leadership to shape and execute enterprise data architecture initiatives, ensuring scalable, trust...
2 weeks ago
$110K - $130K *
Unlock potential by fostering client relationships and expanding service offerings, enhancing market presence in the Consumer, Retail, and Logistics domain through innovative solutions and collaborati...
Reposted 3 weeks ago
Director of Program Management
$135K - $160K *
Transform your career by leading cross-functional teams to drive drug development strategies. Collaborate with key stakeholders to ensure successful execution of integrated plans, manage risks, and de...
1 week ago
Associate Director, Thought Leader Liaison, Oncology - Central
$157K - $256K *
Champion strategic engagements with oncology thought leaders to enhance insights and drive initiatives for our Solid Tumor portfolio, focusing on collaboration across teams and executing regional stra...
1 week ago
$110K - $130K *
Unlock potential by leading cross-functional initiatives to enhance caregiver enrollment technology. Drive strategy, optimize user experiences, and leverage data analytics to achieve growth in a dynam...
Today
$126K - $179K *
Lead the charge in transforming customer support through innovative AI solutions, enhancing satisfaction and operational efficiency. Drive strategic initiatives, foster team excellence, and ensure the...
1 month ago
$120K - $180K *
Drive the growth of our partner channel by leading recruitment and strategy for ISVs, VARs, and ISOs in the payments landscape. Collaborate across teams to enhance partner relationships and expand rev...
1 week ago
General Manager, Healthcare Practices
$275K - $325K *
Drive the growth of healthcare practices by owning strategy, partnerships, and P&L. Collaborate with teams to deliver tailored financial solutions, while leveraging your network to establish Flex as t...
Today
Software Engineering Manager, Billing
$150K - $180K *
Champion the evolution of our billing systems by leading a dynamic engineering team. Drive strategy, ensure accuracy, and collaborate across departments to enhance customer trust as we scale our usage...
1 week ago
Senior Director, Market Access Pricing & Contracting
$175K - $210K *
Drive the development and execution of U.S. pricing and contracting strategies, optimizing patient access and revenue performance. Collaborate across functions to ensure successful commercialization a...
3 weeks ago
Strategic Account Executive- Inventory Services
$94K - $125K *
Empower your career with an impactful role driving sales of complex supply chain solutions in healthcare. Engage C-suite executives, manage strategic accounts, and address industry challenges to deliv...
Reposted 4 weeks ago
Manager/Director, Talent Management
$130K - $170K *
Join a team that's advancing enterprise talent strategy through data-driven performance management, succession planning, and organizational effectiveness, partnering with leaders to build high-perform...
2 weeks ago
Director, Head of Patient Recruitment and Retention, Americas
$171K - $231K *
Drive innovative patient recruitment strategies to enhance clinical trial enrollment and retention. Collaborate with cross-functional teams to implement data-driven approaches, optimize patient engage...
Reposted 4 weeks ago
$84K - $131K *
Partner with us to enhance internal audit processes, evaluate risks, and ensure compliance. Collaborate with teams to assess controls, document findings, and support management in implementing effecti...
3 weeks ago
$72K - $116K *
Engage in financial analysis and reporting, developing forecasts and insights. Collaborate across departments to enhance business outcomes and present findings to management, driving strategic decisio...
Reposted 1 week ago
$110K - $130K *
Unlock compensation strategies by partnering with teams to analyze, model, and deliver data-driven solutions. Drive benchmarking, job architecture, and annual comp cycles to ensure equitable pay pract...
2 weeks ago
Assistant Director, Supervision
$127K - $171K *
Lead a dynamic team in overseeing compliance and supervision for securities and investment advisers. Drive risk mitigation strategies, enhance supervisory frameworks, and collaborate with cross-functi...
3 days ago
Director, Telehealth Sales & Strategic Partnerships
$130K - $160K *
Accelerate growth in telehealth by leading strategic partnerships and business development. Drive revenue through innovative solutions, executive relationships, and a deep understanding of the healthc...
1 week ago
Director, Telehealth Sales & Strategic Partnerships
$135K - $160K *
Join a dynamic team to drive telehealth sales and strategic partnerships, identifying opportunities and building relationships across the healthcare ecosystem. Own the commercial process from prospect...
2 weeks ago
$136K - $214K *
Join a team that's redefining healthcare marketing by crafting compelling narratives and driving innovative go-to-market strategies for AI Care solutions across the Payor ecosystem. Leverage your expe...
3 weeks ago
Associate Director - FP&A Industrial: Manufacturing & Distribution - Private Equity Advisory
$135K - $160K *
Transform the Private Equity landscape by leading FP&A initiatives, enhancing operational efficiencies, and mentoring teams to deliver tailored solutions that drive sustainable value creation for clie...
1 week ago
$110K - $130K *
Champion client success by managing key relationships and driving strategic initiatives. Lead cross-functional teams to deliver high-quality work while ensuring financial performance and growth for as...
Reposted yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.