Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Revenue Cycle Jobs in South Dakota

Sort By: Relevance

$120K - $177K *

Lead and develop a distributed team of Project Coordinators, enhancing operational health and governance across complex automation deployments while driving continuous improvement and collaboration wi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K *

Unlock potential by driving enterprise account strategies and engaging technical leaders. Collaborate with AEs to create meaningful outreach and build a pipeline that converts, focusing on quality int...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$105K - $163K *

Champion client success by leading project teams to deliver high-quality card processing solutions. Drive enhancements, manage complex implementations, and ensure client satisfaction through effective...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $123K *

Lead the charge in pharmaceutical meetings operations, driving client partnerships and operational excellence while navigating compliance. Shape processes and enhance stakeholder engagement to deliver...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Transportation

$120K - $150K *

Elevate your career by leading clinical trial management teams, ensuring quality and compliance in monitoring strategies. Collaborate with cross-functional teams to optimize clinical operations and dr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$147K - $217K *

Lead transformative analytics initiatives in life sciences, driving innovation and client success. Mentor teams, enhance measurement standards, and collaborate cross-functionally to deliver actionable...

RemoteRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$108K - $149K *

Drive revenue operations excellence by enhancing MSSP processes and systems. Collaborate with cross-functional teams to operationalize strategies, streamline workflows, and support partner lifecycle m...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$156K - $235K *

Transform the healthcare sales landscape by leading a dynamic team to drive revenue and margin growth. Leverage your expertise to achieve commercial objectives while fostering strong relationships and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$67K - $100K *

Drive category sourcing strategies and supplier relationships to optimize procurement processes, ensuring alignment with organizational standards and delivering value across assigned categories while...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Lead the charge in developing clinical content strategies and overseeing teams within the market access practice. Drive innovation, enhance client strategies, and ensure high standards in service deli...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$89K - $120K *

Drive collaboration across teams to coordinate scientific data, streamline processes, and enhance operational efficiency. This role requires strong judgment and the ability to manage cross-functional...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$231K - $340K *

Advance enterprise procurement value through strategic insights and influence. Lead high-stakes engagements, build enduring frameworks, and coach teams while presenting compelling value narratives to...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$150K - $185K *

Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...

United StatesRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in clinical study start-up operations, driving team development and ensuring timely site activation. Collaborate cross-functionally to enhance processes, meet regulatory standards, and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$190K - $300K *

Manage and optimize the digital marketing strategy for oncology products, enhancing customer engagement through innovative digital assets. Lead cross-functional teams to execute comprehensive marketin...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$206K - $343K *

Transform your career by leading AI & Data initiatives for Energy Providers. Drive growth, build client relationships, and develop a high-performing team while delivering innovative solutions that add...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$147K - $220K *

Champion transformative health solutions by managing key client relationships, driving sales, and collaborating across teams to enhance Verily's impact in Life Sciences. Leverage expertise to unlock n...

RemoteRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Lead the enhancement of finance systems in a dynamic environment, focusing on optimizing NetSuite and integrating additional solutions. This role involves strategy, system configuration, and process i...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$119K - $186K *

Manage legal services for indirect sourcing, delivering strategic counsel and project management. Negotiate vendor agreements and ensure compliance while collaborating with stakeholders to support bus...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$145K - $160K *

Drive strategic initiatives by leading complex, cross-functional projects that align stakeholders and transform business priorities into actionable plans, ensuring successful execution across Revenue...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Partner with us to enhance clinical IT solutions as an Epic Analyst II, providing critical support, training, and implementation for Epic EHR systems. Collaborate with teams to optimize workflows and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$185K - $255K *

Transform the financial engine of R&D by leading revenue strategies, pricing, and cost management. Collaborate with senior leaders to align short-term goals with long-term product vision, while buildi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Lead and develop engineering teams focused on clinical data integration and insights. Drive the direction of data pipelines and ensure impactful, equitable health outcomes through effective collaborat...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $154K *

Join a dynamic team as a Document Control Supervisor, overseeing document management for construction and engineering projects. Drive process improvements, ensure compliance, and support project teams...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$74K - $98K *

Elevate quality operations by leading corrective action plans (CAPs) for regulatory compliance. Collaborate with cross-functional teams to drive accountability, resolve barriers, and ensure sustained...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.