Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Veeva CRM, Senior Manager - Organizational Change Management (OCM) - Remote, United States
$120K - $145K *
Lead the charge in organizational change management for complex life sciences transformations, focusing on global Veeva CRM implementations. Drive strategy, execution, and stakeholder engagement acros...
1 week ago
Sr Business Analyst - Manufacturing
$68K - $113K *
Lead cross-functional teams to drive the successful launch of a new manufacturing facility, ensuring effective project execution, communication, and continuous improvement...
Reposted today
Senior Director, Counsel, Diagnostics & Medical Devices
$199K - $321K *
Join a dynamic team to provide strategic legal counsel on diagnostics and medical devices, ensuring compliance with FDA regulations and commercial strategies while collaborating across business units...
1 week ago
Product Manager, Growth & Lifecycle
$110K - $130K *
Take ownership of customer-facing products that enhance user journeys. Drive growth through experimentation and data analysis, maximizing conversion and retention while partnering with cross-functiona...
1 month ago
Account Manager - Accredo - Remote
$75K - $125K *
Manage day-to-day client relationships, ensuring satisfaction and retention through effective communication, performance monitoring, and cross-functional collaboration to drive business outcomes and o...
Yesterday
$84K - $100K *
Transform premium accounting operations by leading teams, ensuring compliance, and driving process improvements through analytics and AI tools. Collaborate cross-functionally to enhance service levels...
1 week ago
$170K - $200K *
Champion the evolution of exposure management by leading the design and implementation of a robust operating model, ensuring effective risk reduction and accountability across security operations and...
Reposted 6 days ago
$94K - $107K *
Support and enhance data governance operations by collaborating with teams to implement standards, manage data cataloging, and drive tool adoption, ensuring compliance and effective governance workflo...
3 weeks ago
$90K - $110K *
Unlock potential by driving new business sales in a dynamic, AI-enabled environment. Own your territory, create a robust pipeline, and engage sophisticated buyers to deliver consistent revenue growth...
Yesterday
Technical Revenue Accounting and Policy Manager
$143K - $169K *
Unlock potential by developing and maintaining ASC 606 revenue policies, ensuring compliance and accuracy in revenue recognition. Collaborate cross-functionally to shape contract structures and suppor...
Reposted 1 week ago
$94K - $107K *
Transform data governance operations by driving process adoption, supporting data stewards, and enhancing governance tools. Collaborate with teams to ensure compliance, improve workflows, and leverage...
3 weeks ago
Director, Product Quality Lead
$172K - $232K *
Lead the charge in advancing global quality initiatives, ensuring product excellence, and fostering expertise in quality risk management while collaborating across teams to enhance compliance and oper...
Reposted 3 weeks ago
$110K - $130K *
Lead and guide project teams in implementing GRC and cybersecurity programs, ensuring the effectiveness of IT controls and compliance frameworks while mentoring junior staff and managing client relati...
Reposted 3 days ago
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
3 weeks ago
$108K - $135K *
Elevate your career by overseeing treasury operations, managing liquidity, and enhancing banking relationships. Collaborate with finance teams to align strategies with financial objectives, ensuring o...
1 week ago
$100K - $130K *
Drive the future of revenue accounting by ensuring accurate recognition and compliance with ASC 606. Collaborate cross-functionally to streamline processes, support complex deals, and maintain audit r...
1 week ago
$200K - $232K *
Unlock potential by leading legal reviews for promotional and medical materials. Collaborate across teams to ensure compliance and provide practical guidance in a fast-paced environment, supporting pr...
2 weeks ago
Sr. Manager - Loan Portfolio & Revenue (R14333)
$112K - $180K *
Lead the evolution of revenue forecasting and lending portfolio planning, enhancing financial models and insights. Collaborate across functions to drive strategic analysis and improve decision-making...
1 week ago
Regulatory Promotional Review Specialist
$80K - $95K *
Optimize the promotional review process by coordinating cross-functional workflows, ensuring compliance, and facilitating timely approvals of marketing materials. Collaborate with internal and externa...
Yesterday
Director, Employer Sales - National Accounts
$349K - $396K *
Lead the charge in driving national growth strategies for enterprise employers, managing a top-performing sales team focused on Fortune 500 engagements, overseeing the acquisition lifecycle, and ensur...
Reposted 2 weeks ago
Account Manager II (Remote Southeast Territory)
$67K - $101K *
Innovate your sales career by driving revenue growth and building lasting customer relationships. Own your territory, manage the full sales cycle, and collaborate with teams to accelerate deals and en...
Reposted 1 week ago
Senior Specialist, Epic Solution Delivery (Ambulatory)
$110K - $130K *
Lead the charge in Epic solutions delivery by providing expert support, managing projects, and mentoring team members. Shape the future of healthcare IT by aligning technical teams with stakeholder ne...
Reposted today
$112K - $140K *
Transform your career by leading claims advocacy efforts, managing complex coverage issues, and providing expert guidance to brokers and clients. Collaborate with teams to ensure positive outcomes and...
3 weeks ago
$127K - $165K *
Unlock potential by leading regulatory strategies for innovative medical devices. Collaborate with teams to ensure compliance, execute FDA submissions, manage project timelines, and establish processe...
Reposted 5 days ago
Director, Growth & Retention - Shopper
$225K - $275K *
Lead the charge in driving shopper growth, transforming casual users into engaged buyers through innovative acquisition and retention strategies while overseeing a dedicated team from day one...
1 month ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.