Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Lead Analyst, Independent Dispute Resolution (IDR)
$80K - $95K *
Shape the future of healthcare revenue management by leading IDR processes, ensuring compliance, and driving data-informed improvements while mentoring a team of analysts to optimize workflows and enh...
6 days ago
Director, GCP Inspection Management- Americas
$172K - $232K *
Lead the GCP Inspection Management team to ensure inspection readiness and compliance. Oversee strategy development, cross-functional collaboration, and risk mitigation for successful regulatory inspe...
3 weeks ago
Program Director, Professional Services
$150K - $170K *
Lead a dedicated team to drive client success across diverse delivery modes, ensuring effective governance and coordination. Drive business development within a portfolio, nurturing critical client re...
Reposted 2 weeks ago
$96K - $116K *
Champion innovative medical policy solutions by analyzing data, ensuring quality, and collaborating across clinical operations. Drive enhancements in payment policy management while supporting diverse...
1 week ago
Health Policy and Government Relations Partner
$110K - $130K *
Lead the development and implementation of health policy initiatives that align with organizational goals. Collaborate with stakeholders to influence policy decisions and improve health outcomes at lo...
Yesterday
$195K - $240K *
Champion the growth of NeoCloud sales by building a dedicated team and strategy to secure key accounts, drive long-term contracts, and enhance customer relationships in a dynamic, AI-driven market...
1 week ago
Senior Manager, Global Payroll
$142K - $210K *
Transform global payroll operations by leading a team to ensure compliance, accuracy, and efficiency across US and international payrolls while managing complex tax and pay issues...
1 week ago
Director, UCC & Tax Lien Compliance
$190K - $304K *
Drive operational excellence in managing merchant liens and levies compliance. Build a specialized team, establish governance frameworks, and ensure effective collaboration across departments to creat...
3 weeks ago
Clinical Care Manager, Transitions of Care
$69K - $101K *
Join us to enhance member health outcomes through holistic care management, collaborating with multidisciplinary teams to support individuals with complex needs. Utilize assessments and interventions...
3 weeks ago
Senior Manager, Drug Safety & Pharmacovigilance
$132K - $172K *
Lead pharmacovigilance operations and safety science initiatives, ensuring compliance and quality in drug safety reporting. Oversee vendor performance, manage safety data, and contribute to regulatory...
2 weeks ago
$170K - $195K *
Elevate revenue growth by building strong relationships with law firms and corporations. Drive new business development through consultative sales, leveraging industry insights and collaboration with...
1 week ago
Professional Services Operations Lead
$88K - $105K *
Drive operational excellence by owning the Professional Services intake and workflow governance processes, ensuring efficient request management and seamless team collaboration to enhance service deli...
2 days ago
Senior Consultant - Healthcare Compliance
$100K - $125K *
Empower healthcare compliance by enhancing programs, mitigating risks, and driving operational integrity. Collaborate with diverse clients to deliver tailored solutions in a dynamic regulatory landsca...
3 weeks ago
$130K - $175K *
Transform IT operations by establishing automated, self-service systems while ensuring ISO compliance. As a crucial partner across functions, you'll enhance security protocols, streamline workflows, a...
Reposted 3 weeks ago
$110K - $130K *
Drive new business in Facility Management by identifying prospects, analyzing market needs, and converting leads into clients. Collaborate with marketing and sales teams to deliver tailored solutions...
3 weeks ago
$128K - $192K *
Unlock potential by driving new business growth through actionable health intelligence. Build relationships, identify client needs, and showcase solutions to enhance employee wellbeing and manage heal...
Today
Associate Director, Strategic Accounts (New England)
$135K - $160K *
Unlock potential by leading a dynamic sales team in hematology, driving strategic account management and fostering key stakeholder relationships to enhance the clinical experience with ZYNLONTA across...
1 week ago
Director, Medical Science Liaison (East)
$148K - $222K *
Drive clinical adoption and enhance partnerships by leading a high-performing Medical Science Liaison team. Collaborate with sales and medical teams to educate stakeholders, influence decision-making...
1 week ago
$97K - $113K *
Lead financial operations and strategic planning for program teams, ensuring effective budget management, resource allocation, and compliance with regulations. Drive process improvements and enhance E...
6 days ago
Workday Financials Senior Principal Consultant, Record to Report - Global AMS
$128K - $192K *
The Workday Financials Senior Principal Consultant, Record to Report is a dynamic professional responsible for leading the Financials workstream and ensuring operational efficiency in Workday engageme...
Reposted 5 days ago
Senior Financial Analyst (Consolidation)
$100K - $120K *
Lead the consolidation of financial models and metrics, partnering with cross-functional teams to deliver actionable insights and support strategic decision-making across the organization...
2 days ago
Vice President, Strategic Accounts (B2B Software)
$215K - $240K *
Transform how organizations engage with high-value clients by leading a global sales team. Drive account growth, retention, and strategic partnerships while developing comprehensive multi-year account...
Reposted today
$175K - $225K *
Contribute to the growth of our retail segment by leading human capital strategies that optimize talent acquisition, performance management, and organizational design in alignment with business object...
Reposted 3 weeks ago
Manager, Product Management, Member Interaction & Engagement Data
$108K - $180K *
Shape the future of product development, leading cross-functional teams to execute strategic initiatives and optimize customer engagement through innovative data solutions and market insights. Drive i...
Reposted 1 month ago
$200K *
Lead the charge in building and scaling AI Data Operations, transforming emerging opportunities into commercially viable solutions. Drive strategy, partnerships, and operational excellence to support...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.