Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Associate Director, Strategic Accounts (Texas)
$135K - $160K *
Contribute to the success of a dynamic sales team by managing key accounts, leading a team of specialists, and driving advocacy for innovative hematology solutions. Collaborate cross-functionally to e...
1 week ago
Director, Global Drug Safety & Pharmacovigilance Operations
$150K - $180K *
Advance global drug safety initiatives by leading pharmacovigilance activities, ensuring compliance with regulations, and collaborating with cross-functional teams to enhance product safety and operat...
2 days ago
Senior Product Manager, Value realization
$104K - $143K *
Deliver impactful reporting solutions by translating measurement needs into actionable requirements, managing backlogs, and collaborating with cross-functional teams to ensure effective execution and...
3 days ago
Global Category Lead - Value & Access, Associate Director
$148K - $201K *
Drive category strategy and supplier relationships to enhance Market Access, Pricing, and Health Economics. Collaborate with cross-functional teams to optimize procurement processes and improve operat...
1 week ago
Senior Director, Delivery Excellence
$207K - $277K *
Lead the charge in enhancing global ERP delivery excellence, driving governance, quality, and continuous improvement across teams. Foster collaboration and optimize resource utilization to ensure pred...
3 weeks ago
Senior Sales Operations Analyst
$79K - $120K *
Partner with us to enhance sales efficiency by owning project-level workstreams, streamlining processes, and utilizing data analytics to empower our Enterprise Account Executives to focus on customer...
Reposted 2 weeks ago
$95K - $128K *
Shape the future of sales operations by collaborating with senior leaders to optimize processes, streamline workflows, and enhance efficiency for Enterprise Account Executives, driving impactful chang...
Reposted 4 weeks ago
Sr. Director, Strategy & Execution
$160K - $200K *
Transform the future of go-to-market strategy by leading cross-functional teams, driving execution governance, and shaping long-range plans to achieve growth objectives in a dynamic, global environmen...
3 weeks ago
$150K - $180K *
Optimize quality operations for large-scale data pipelines, ensuring high standards and consistency across diverse datasets. Lead a team to enhance efficiency and reliability in audio data processing...
3 weeks ago
$109K - $164K *
Drive advanced digital forensics and incident response initiatives while mentoring a skilled engineering team. Leverage deep technical knowledge to enhance operational capabilities and ensure exceptio...
Reposted 2 weeks ago
Executive Medical Director (Retina Program)
$350K - $398K *
Drive impactful clinical trials in ophthalmology with leadership in study design, execution, and biomarker strategy. Collaborate cross-functionally to ensure timely delivery and regulatory compliance...
Reposted 3 weeks ago
$133K - $225K *
Unlock potential by leading a high-performing accounting team, overseeing statutory reporting across international entities, and ensuring accurate financial management while driving process optimizati...
3 weeks ago
$117K - $158K *
Manage and prioritize the ERP product backlog, translating business needs into actionable requirements. Collaborate with stakeholders to enhance operational effectiveness and drive continuous improvem...
Yesterday
Sr. Manager - Procurement Services
$140K - $180K *
Accelerate procurement excellence by leading high-impact customer engagements, driving strategic initiatives, and fostering a culture of continuous improvement within a dynamic team environment...
2 weeks ago
$175K *
Shape the future of global telecommunications by leading strategy, architecture, and operations for voice and video infrastructure, ensuring reliable and cost-effective communication services aligned...
1 week ago
Manager, Clinical Lab Project Management
$114K - $187K *
Champion clinical laboratory operations by managing complex projects, ensuring timely study starts, and collaborating with cross-functional teams to deliver impactful results in precision medicine...
3 weeks ago
$180K - $205K *
Drive financial excellence by delivering insights and analysis for the Field Service organization. Collaborate across departments to enhance forecasting, budgeting, and operational efficiency while su...
1 week ago
$120K - $145K *
Transform your career by driving VAR growth across North America. Lead partner recruitment, develop strategic plans, and enhance sales execution to achieve sustainable revenue growth in the mid-market...
2 days ago
Senior Director, Early Oncology
$230K - $345K *
Transform clinical trial management by leading early-phase oncology programs. Drive strategic vision, operational excellence, and cross-functional collaboration to ensure timely, budget-compliant exec...
Yesterday
$95K - $115K *
Unlock potential by driving business growth in the Geo division. Build relationships with engineers and contractors, educate on product offerings, and secure bidding opportunities. Remote work availab...
1 week ago
Sr Manager, Pricing Transformation
$131K - $180K *
Lead the transformation of enterprise pricing by managing the implementation of a modern pricing platform, ensuring seamless integration across departments while driving governance, change management...
3 weeks ago
$104K - $153K *
Elevate your career by leading the Inside Sales strategy to drive growth, enhance customer engagement, and develop a high-performing team. Collaborate across functions to optimize processes and delive...
3 weeks ago
Executive Director, Clinical Operations
$285K - $310K *
Lead the strategic execution of global clinical trials, ensuring adherence to timelines, budgets, and quality standards while fostering collaboration across teams and mentoring Clinical Operations per...
6 days ago
$160K - $185K *
Unlock your potential by leading a dynamic team to drive channel partnerships, transforming opportunities into revenue-generating relationships across diverse verticals in a fast-growing ecosystem...
1 week ago
Program Specialist, Care Management
$74K - $119K *
Transform healthcare delivery by coordinating strategic programs that enhance clinical and operational excellence. Collaborate with diverse teams to implement innovative solutions, ensuring compliance...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.