Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Contract and Billing Specialist
$84K - $128K *
Join a team that's dedicated to resolving complex billing and contract cases for Mid-Market and Commercial accounts. You'll collaborate cross-functionally to enhance customer satisfaction and streamli...
1 week ago
Senior Director, Sales (Enterprise West)
$175K - $210K *
Lead and grow a high-performing sales team, driving enterprise revenue and strategy in a dynamic market. Collaborate with partners and stakeholders to expand business while shaping product direction a...
2 days ago
Executive Director Access Services - Immunology
$255K - $424K *
Lead the development and execution of Immunology access services strategy, ensuring seamless patient and provider experiences. Collaborate cross-functionally to enhance reimbursement initiatives and d...
3 days ago
Director - Americas Engineered Equipment
$150K - $180K *
Transform the Industrial Segment by leading growth strategies across the Americas. Drive sales accountability, foster key relationships, and collaborate cross-functionally to enhance customer satisfac...
Today
Vice President of Product and Technology PMO
$247K - $321K *
Accelerate progress at a high-growth SaaS organization by leading the Product & Technology PMO, driving execution excellence across R&D initiatives and fostering strategic alignment to scale operation...
Reposted 3 weeks ago
Director, Analytical Development and Quality Control
$192K - $235K *
Lead analytical development and quality control for sterile parenteral products, ensuring regulatory compliance and successful product launches. Collaborate cross-functionally to establish strategies...
1 week ago
Group Lead Operations Account Management
$110K - $130K *
Lead the charge in operational excellence by overseeing performance across client accounts, ensuring effective communication and high-quality execution in revenue cycle management, while mentoring tea...
2 days ago
$135K - $237K *
Unlock potential by leading actuarial strategies that drive innovation and performance. Oversee a team, develop statistical models, and engage with regulators to ensure compliance and support business...
3 weeks ago
$110K - $130K *
Reimagine medical communication by leading a team of writers to craft regulatory and scientific documents. Oversee projects, ensuring clarity and quality for diverse audiences while adhering to timeli...
Reposted 3 weeks ago
Senior Consultant, Healthcare Finance (Healthcare & Medicaid Finance and Analysis)
$95K - $130K *
Unlock potential by driving healthcare finance consulting excellence. Collaborate with project teams to enhance service delivery through financial modeling, data analytics, and quality improvement ini...
1 week ago
$80K - $95K *
Transform credentialing operations by leading a dedicated team to ensure compliance, enhance efficiency, and support provider network growth through strategic oversight and process improvement initiat...
2 weeks ago
$83K - $140K *
Lead the charge in financial modeling and forecasting, driving strategic insights and collaborative planning processes across Corporate Finance & Strategy to optimize performance and align financial g...
Reposted 4 weeks ago
Senior Product Manager, Quantum
$138K - $165K *
Champion the future of quantum computing by defining product vision and driving development for innovative solutions. Collaborate with cross-functional teams to integrate quantum capabilities into SAS...
Yesterday
Director of Data Center Services
$125K - $150K *
Lead the charge in operational excellence for a Data Center Services unit, driving performance, workforce development, and customer satisfaction across multiple locations while overseeing mission-crit...
3 weeks ago
Project Director, Dermatology and Rheumatology, CRO, US, remote USA
$125K - $150K *
Oversee a portfolio of clinical studies, ensuring compliance and quality. Lead Project Managers in executing complex trials, driving operational efficiency and client satisfaction while leveraging you...
2 weeks ago
Project Manager for Service Delivery - Atlanta, GA
$95K - $115K *
Join a team that's dedicated to delivering successful projects on time and on budget. As a key player, you'll drive project planning, coordinate with stakeholders, and ensure effective communication t...
Reposted 2 weeks ago
$82K - $153K *
Unlock potential by driving acquisition strategies and building relationships with agency owners. Collaborate with leadership to enhance deal pipelines and support growth initiatives through effective...
Today
Manager Pricing - Retail, Technology, Healthcare
$105K - $115K *
Lead financial pricing strategies and support sales operations through analytical insights, forecasting, and continuous improvement initiatives. Collaborate with cross-functional teams to optimize mar...
2 weeks ago
$81K - $110K *
Lead the transformation of patient care by enhancing utilization review processes, ensuring quality documentation, and collaborating with healthcare teams to optimize clinical outcomes and financial p...
3 days ago
Commercial Director- Model Audit, Model Build and Transactions Advisory
$125K - $150K *
Shape the future of financial modelling by leading a dynamic team responsible for analyzing and auditing complex financial models, ensuring reliability, and driving growth within a collaborative envir...
Reposted 2 days ago
Product Management Senior Advisor
$113K - $188K *
Champion the development of innovative tools for customer service teams, enhancing agent efficiency and service quality. Collaborate across departments to drive product strategy, leveraging data and u...
6 days ago
Associate Director, Strategic Accounts (Texas)
$135K - $160K *
Contribute to the success of a dynamic sales team by managing key accounts, leading a team of specialists, and driving advocacy for innovative hematology solutions. Collaborate cross-functionally to e...
1 week ago
$148K - $163K *
Transform financial systems through leadership in automation, AI, and strategic planning. Oversee the integrity of core finance technology and collaborate across departments to enhance operational eff...
Reposted 3 weeks ago
Product Manager, Clinical Programs & Case Management
$86K - $138K *
Unlock innovative healthcare solutions by leading product strategy and lifecycle management for clinical programs. Collaborate across teams to enhance member experiences and drive business value while...
1 week ago
$110K - $130K *
Partner with us to tackle complex operational challenges, driving impactful initiatives across our portfolio. This role offers hands-on experience and growth opportunities, ideal for future leaders ea...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.