Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Associate Director, Virtual Health
$115K - $125K *
Elevate virtual health services by leading strategic initiatives, enhancing patient experiences, and driving operational excellence. Collaborate across teams to implement innovative care models and en...
2 days ago
$88K - $154K *
Optimize document management processes for a large-scale industrial project, ensuring accurate, secure, and accessible records throughout all project phases. Collaborate with multidisciplinary teams t...
6 days ago
Senior Account Manager, Med Affairs
$90K - $105K *
Collaborate with clients and teams to manage projects, expectations, and delivery, ensuring high standards and strategic growth in a fast-paced medical affairs environment. Leverage experience to iden...
Reposted 1 week ago
Senior Account Director (Medical Affairs)
$155K - $175K *
Lead the charge in client partnerships while driving strategic growth and team development. Utilize your expertise to deliver impactful insights and solutions in a fast-paced, evolving environment, en...
Reposted 2 weeks ago
$80K - $95K *
Take ownership of payroll operations, ensuring accuracy and compliance while leading a team to deliver timely wage payments and manage tax obligations effectively across the organization...
6 days ago
Revenue Operations Manager, Sales Ops
$120K - $145K *
Reimagine revenue operations by leading the design and execution of systems and processes that enhance sales performance. Collaborate cross-functionally to optimize workflows, improve data visibility...
3 weeks ago
Information Systems Security Officer
$143K - $175K *
Transform the landscape of information security by leading comprehensive RMF assessments and mentoring junior staff. Drive compliance and innovation in cybersecurity for emerging technologies while ma...
Yesterday
Director, Transactional Risk Monitoring
$125K - $150K *
Lead the charge in monitoring transactional risk for banking and treasury services, ensuring effective fraud detection and credit risk management across multiple program layers while driving resolutio...
1 week ago
$150K - $185K *
Shape strategic success for key accounts by leading market access initiatives, collaborating with cross-functional teams, and driving growth through innovative solutions and insights in the managed ma...
3 weeks ago
$110K - $130K *
Lead the charge in transforming complex genomic data into compelling narratives that resonate with audiences, driving engagement across diverse channels while collaborating with cross-functional teams...
1 week ago
AD/Director, Regulatory Affairs CMC
$190K - $285K *
Advance regulatory strategies for global CMC submissions, managing cross-functional collaboration and internal processes to meet compliance with health authority standards, while leveraging strong com...
Reposted 3 weeks ago
Clinical Informatics & Ontology Lead
$120K - $145K *
Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...
Today
Data Integration Administrator, TPA
$74K - $115K *
Join a dynamic team to develop and support SQL-based ETL processes, ensuring data quality and integration performance across business applications. Collaborate with technical teams to enhance data exc...
2 weeks ago
Associate Director, Project Management
$117K - $189K *
Pioneer global Orexin development programs by driving project management efforts. Partner with the Global Team Leader to oversee cross-functional teams, manage critical activities, and ensure project...
Reposted 3 days ago
Associate Director, Regulatory Science
$177K - $221K *
Champion regulatory excellence by leading cross-functional teams, ensuring compliance, and driving successful oncology drug development through strategic planning and expert guidance...
1 week ago
Delivery Director-Telecommunications-ServiceNow TSOM, CSM, TI, FSM, OSS, BSS
$150K - $180K *
Lead the charge in driving operational excellence and portfolio growth, ensuring customer satisfaction and seamless delivery across innovative projects. Collaborate with sales and project teams to ele...
Reposted 2 weeks ago
$80K - $100K *
Lead the charge in delivering comprehensive audit services, enhancing client relationships, and mentoring junior staff while managing multiple engagements in a dynamic, results-driven environment...
1 week ago
Senior Manager, Solution Engineering - DocV
$135K - $160K *
Drive customer success and system reliability by leading a high-impact, agile engineering team focused on short-term initiatives that enhance product adoption and solve complex integration challenges...
Reposted 4 weeks ago
$110K - $130K *
Lead large-scale automation projects, guiding teams through all phases with a focus on customer satisfaction, operational excellence, and financial management in a collaborative environment...
Reposted 1 week ago
Director Product Management - Workflows & AI
$190K - $275K *
Lead the strategy and execution of AI and workflow capabilities, driving innovative solutions that enhance user experience and business outcomes across a scalable product suite. Mentor a team of Produ...
Reposted 3 weeks ago
Medical Director, Occupational Health & Workers' Compensation Managed Care
$300K *
Elevate healthcare delivery by leading a dedicated team in clinical evaluations, ensuring best practices while providing client-facing support and expertise in medical claims, regulations, and emergin...
Reposted 2 weeks ago
Senior Director Payer Contracting
$150K - $180K *
Join us to lead payer contracting strategies, negotiate complex agreements, and enhance reimbursement performance across diverse healthcare models while managing a high-performing team in a dynamic, r...
3 weeks ago
$154K - $242K *
Champion operational excellence by leading global tax provisions and compliance. Collaborate with cross-functional teams to enhance processes, mentor talent, and drive strategic tax initiatives while...
3 days ago
$210K - $260K *
Join a fast-paced team of medical professionals to evaluate and enhance service appropriateness through evidence-based guidelines, impacting quality patient outcomes across multiple specialties while...
Reposted 3 weeks ago
$127K - $203K *
Join the charge in shaping technical solutions by transforming stakeholder needs into actionable requirements, fostering collaboration within teams, and ensuring project success throughout the product...
Reposted 3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.