Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Head of Customer Success, Payer & Employer
$137K - $205K *
Transform customer relationships by leading a team to enhance account management, drive product adoption, and ensure client success in the healthcare sector, fostering growth and retention across dive...
3 weeks ago
Product Manager, Billing & Collections
$132K - $165K *
Shape the future of billing and collections by driving product strategy and enhancing user experiences. Collaborate with cross-functional teams to deliver reliable payment solutions that boost revenue...
3 weeks ago
Associate Director/Director, Asset Acquisition
$190K - $250K *
Analyze and evaluate therapeutic opportunities to drive innovation and business development. Collaborate with interdisciplinary teams to assess scientific and commercial viability, ensuring alignment...
Today
Account Manager- Client Success
$80K - $85K *
Grow your career with a dynamic team focused on client success, managing relationships, and delivering tailored solutions. Drive satisfaction and retention while collaborating across departments to en...
1 week ago
Associate Medical Director (Promotional Medical Education)
$100K - $125K *
Manage a team of medical writers to develop impactful scientific content, ensuring accuracy and compliance. Collaborate with clients and cross-functional teams to drive medical strategies and delivera...
Reposted 1 week ago
Account Executive, HME Provider Sales
$80K - $100K *
Join a team that's driving growth by acquiring new customers and enhancing revenue through innovative solutions. Manage the full sales cycle while collaborating with cross-functional teams to ensure e...
3 days ago
Senior Director, Clinical Diagnostics and Precision Medicine
$242K - $403K *
Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...
2 weeks ago
$110K - $130K *
Manage and lead field-based medical teams, ensuring client delivery and team performance while fostering scientific engagement and program growth. Collaborate with cross-functional teams to achieve st...
3 weeks ago
Payment Integrity Program Manager
$73K - $120K *
Drive the success of inpatient Payment Integrity programs by overseeing audits, ensuring compliance, and enhancing quality across teams and vendors. Collaborate with stakeholders to optimize processes...
3 weeks ago
Business Transformation Analyst - Finance
$88K - $105K *
Join a dynamic team to drive enterprise-wide transformation initiatives, leveraging data analysis and AI to enhance performance and innovation across departments, while fostering collaboration and ali...
Yesterday
$158K - $185K *
Join a dynamic team dedicated to revolutionizing cardiac health through innovative sales leadership. Guide a team of Territory Managers, driving revenue growth and operational excellence across a desi...
Reposted 5 days ago
$145K - $160K *
Lead the charge in transforming member support by defining strategy, enhancing team performance, and integrating AI solutions. Drive operational excellence while fostering a culture of empathy and acc...
3 days ago
Director, Disease Area Strategy Lead - General Medicine
$195K - $265K *
Lead the strategic direction of General Medicine, integrating scientific and commercial insights to drive portfolio decisions and early pipeline projects, while fostering cross-functional collaboratio...
3 weeks ago
Senior Financial Analyst, Cost Accounting
$58K - $125K *
Accelerate progress at the intersection of finance and strategy, driving cost accounting excellence and profitability analysis. Collaborate with cross-functional teams to enhance financial reporting a...
4 weeks ago
Director, Ohio Transportation Infrastructure
$157K - $283K *
Unlock your leadership potential as you drive innovative transportation projects in Ohio. Collaborate with stakeholders to enhance infrastructure, optimize project delivery, and lead a dynamic team to...
Reposted 3 weeks ago
Sr Editor, Consent Form Development
$66K - $116K *
Elevate your career by joining a team that reviews and edits informed consent forms, ensuring compliance with regulatory standards while mentoring new editors and enhancing organizational knowledge in...
1 week ago
Senior Director, Liquid Processing & Capital Projects Engineering
$176K - $205K *
Lead the charge in executing complex capital projects and liquid processing strategies. Drive innovation and efficiency across manufacturing networks while mentoring engineering teams and ensuring pro...
6 days ago
Professional Services Manager (HEDIS & Risk)
$95K - $115K *
Lead the charge in managing client engagements within healthcare, translating complex data and workflows into actionable solutions. Drive customer success by fostering relationships and guiding client...
Today
Director, Technology Alliances
$190K - $275K *
Join a team that's driving strategic technology alliances to transform integrations into robust commercial partnerships, focusing on co-selling, joint marketing, and stakeholder alignment while leadin...
Reposted 2 weeks ago
Project Director, Virtual Services
$85K - $105K *
Transform virtual resettlement services by leading a national portfolio that enhances access for refugees. Oversee strategy, implementation, and compliance while fostering partnerships and innovative...
1 week ago
Senior Case Manager, Reimbursement
$80K - $95K *
Lead the charge in case management by overseeing complex pharmacy reimbursement processes, ensuring timely completion of cases, and advocating for patients while collaborating with healthcare provider...
2 weeks ago
Director II Capture & Proposal Public Sector (SLED)
$163K - $218K *
Empower your career by leading SLED capture and proposal strategies. Drive growth and engage diverse teams in this pivotal role, shaping public sector outcomes through innovative procurement and partn...
Reposted 1 week ago
Assistant General Counsel - Corporate, Commercial & Structured Finance
$245K - $310K *
Champion innovative financing solutions as a strategic legal leader, overseeing structured finance, capital markets, and corporate law. Drive legal execution and team growth while ensuring compliance...
1 week ago
Sr. Manager, Industry Relations (RPh)
$132K - $166K *
Drive impactful relationships with pharmaceutical manufacturers, leading contract negotiations and strategic initiatives to enhance specialty pharmacy access and compliance. Oversee team performance a...
2 weeks ago
$150K - $180K *
Lead the charge in expanding and retaining enterprise client relationships, driving revenue growth and strategic account management across regions. Develop and mentor a high-performing account team to...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.