Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Manager, Clinical Data Management Study Lead
$114K - $187K *
Optimize clinical data management processes by leading teams and ensuring compliance with standards. Collaborate with stakeholders to enhance data quality and streamline operations across multiple com...
2 days ago
Area Director, Electrophysiology & Structural Heart-West
$176K - $243K *
Unlock potential by driving the adoption of advanced electrophysiology solutions through strategic partnerships, enhancing customer engagement, and fostering relationships with key stakeholders to ens...
Yesterday
Senior Director, Commercial Operations
$215K - $235K *
Pioneer comprehensive commercial operations by designing, implementing, and optimizing pricing and deal negotiation processes. Drive ongoing analytics and continuous improvement, ensuring success in a...
Reposted 4 weeks ago
$80K - $95K *
Join a team that's redefining inpatient coding operations, ensuring quality and compliance while optimizing workflows. Lead a dedicated team to enhance documentation practices and support financial he...
2 weeks ago
Director, Commercial Programs Pricing and Analytics
$125K - $150K *
Drive pricing strategy and analytics for power distribution products, ensuring competitive market positioning and margin protection. Collaborate cross-functionally to enhance quoting processes and del...
2 days ago
Associate Director, Omnichannel & Media Strategy
$90K - $115K *
Explore a strategic leadership role focused on developing omnichannel engagement strategies that connect media, analytics, and customer experiences, driving measurable outcomes for healthcare brands a...
1 week ago
Director of Operations, ES - Tampa, FL
$143K - $196K *
Elevate healthcare delivery by leading strategic partnerships and optimizing operations within Oncology service lines. Drive performance through exceptional customer engagement and collaboration acros...
2 weeks ago
$215K - $289K *
Lead the charge in driving legal strategy and contract negotiations across all business units, ensuring compliance and supporting revenue growth through effective collaboration with sales, finance, an...
4 weeks ago
Product Manager, File and Remit
$120K - $145K *
Transform the future of tax compliance by building a scalable filing platform and remittance infrastructure, enabling seamless global transactions and automation for international sellers. Drive innov...
3 weeks ago
$101K - $126K *
Join a dynamic team to lead complex projects, ensuring timely delivery and alignment with strategic goals. Collaborate across departments, manage risks, and mentor others while leveraging best practic...
2 weeks ago
$106K - $197K *
Elevate your career by managing complex revenue accounting activities, leading process improvements, and collaborating across teams to enhance scalability and efficiency in a dynamic environment focus...
3 days ago
Director, Transformation & AI Enablement
$181K - $208K *
Lead the charge in enterprise transformation and AI enablement, driving strategic initiatives and measurable outcomes through collaboration with cross-functional teams and senior leaders to enhance bu...
Yesterday
$180K - $220K *
Develop and execute comprehensive tax strategies to optimize cash flow, ensure compliance, and support acquisition-driven growth. Lead a high-performing tax organization while advising executive leade...
4 weeks ago
VP, Payer Sales - National Accounts
$160K - $172K *
Elevate your career by driving growth in national health plan accounts. Leverage your expertise to build relationships, negotiate complex deals, and exceed revenue targets while collaborating with cro...
2 weeks ago
Associate Director, Clinical Solutions Engineering
$177K - $221K *
Drive the development and implementation of innovative clinical solutions, leading a technical team to deliver AI-enabled applications and analytics. Collaborate with stakeholders to ensure scalable...
Today
Director - Portfolio Valuation & Decision Analysis
$112K - $236K *
Drive strategic decision-making by evaluating investment alternatives and lifecycle opportunities. Collaborate with cross-functional teams to optimize portfolio value and support program planning thro...
1 week ago
VICE PRESIDENT, OPERATIONS (SOUTHEAST)
$180K - $220K *
Drive the future of healthcare operations by leading a $300M portfolio, fostering physician partnerships, and executing growth strategies while managing financial and operational performance for a dyn...
Reposted 1 week ago
$110K - $130K *
Explore a pivotal role overseeing financial management, budgeting, and compliance. Collaborate with leadership to provide insights that drive operational decisions and ensure organizational sustainabi...
1 week ago
Executive Director, Health Economics & Outcomes Research (HEOR)
$246K - $332K *
Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...
1 week ago
Director, Workforce Strategy & Transformation
$150K - $180K *
Champion strategic workforce planning and AI-driven work design to enhance capability, improve productivity, and advance internal mobility across teams. Drive tools and strategies aligning workforce p...
Reposted today
$150K - $180K *
Elevate client relationships by managing strategic Tier 1 accounts, driving revenue growth, and ensuring customer satisfaction. Collaborate cross-functionally to develop account strategies and deliver...
3 weeks ago
Director, Patient Access (Travel)
$92K - $125K *
Drive operational excellence in patient access by leading teams, enhancing processes, and fostering collaboration across healthcare facilities. Your leadership will ensure compliance, improve patient...
Today
Senior Manager, Regulatory Affairs
$120K - $145K *
Transform regulatory strategies for rare disease and cardio-pulmonary drug-device programs. Collaborate with cross-functional teams to ensure compliance and drive successful submissions globally, supp...
2 weeks ago
$193K - $241K *
Lead and oversee Medical Information teams, ensuring high-quality service delivery and compliance. Drive strategic initiatives, manage resources, and collaborate cross-functionally to enhance operatio...
6 days ago
$100K - $300K *
Unlock potential by driving enterprise growth in non-commercial foodservice technology. Own the full sales lifecycle, engage stakeholders, and deliver tailored solutions that enhance operational effic...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.