Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$100K - $120K *

Transform nursing services through strategic leadership, ensuring compliance, quality improvement, and patient-centered care across all locations while mentoring clinical staff and enhancing operation...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$182K - $198K *

Build and lead a robust Service Management Office to enhance IT operations, ensuring effective governance, accountability, and continuous improvement across a complex 24x7 environment, while fostering...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$168K - $264K *

Drive the development of mechanistic models to guide RNA therapeutic design, collaborating closely with chemists and biologists to enhance siRNA efficacy across various disease programs through advanc...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Transform the future of healthcare operations by leading strategic projects that enhance patient care, optimize processes, and drive revenue growth across multi-site practices. Collaborate with stakeh...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead strategic initiatives to enhance operational efficiency and patient experience across multi-site healthcare operations. Collaborate with stakeholders to drive measurable improvements in revenue a...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Shape a culture of safety and accountability by leading and enhancing the clinical risk management program, while collaborating with clinical leaders to mitigate risks and improve processes across the...

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$161K - $235K *

Empower transformative clinical excellence in rehabilitation services, leading a dynamic team to enhance patient care and operational efficiency across multiple facilities while fostering collaboratio...

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$180K - $220K *

Transform medical strategies by leading a team of experts, ensuring compliance and scientific accuracy in communications, and fostering client relationships to drive innovative healthcare solutions...

New York, NYRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Unlock your potential by leading medical strategies in a dynamic environment. Drive compliance, mentor a talented team, and collaborate with clients to ensure scientific accuracy in promotional materi...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Lead and optimize daily operations of a Care Concierge team, ensuring performance meets SLAs while managing staffing, training, and development across a 24/7 environment. Drive efficiency and enhance...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $140K *

Shape the future of healthcare operations by leading a dynamic team, ensuring optimal performance and patient satisfaction across a 24/7 Care Concierge function while driving continuous improvement an...

New York, NYRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $320K *

Champion transformative healthcare by leading care management initiatives, enhancing quality and access across services. Collaborate with leadership to optimize operations, improve patient outcomes, a...

Today

  •   11 - 15 years exp.  •   Healthcare

$85K - $100K *

Elevate clinical operations by managing Emergency Department nursing assignments, coordinating staffing, and ensuring quality care across multiple sites. Collaborate with teams to support contract lau...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to enhancing patient care through effective leadership and operational excellence. Oversee nursing and CMA operations, ensuring quality, safety, and improved health outcom...

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$186K - $279K *

Drive the scientific foundation for trustworthy clinical AI systems, leading research and evaluation methodologies. Collaborate with cross-functional teams to ensure scalable, regulated practices that...

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$203K - $247K *

Lead competitive intelligence and strategic insights for immunology initiatives. Collaborate across functions to provide commercial assessments and forecasts, guiding portfolio strategy and executive...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$345K - $375K *

Lead the charge in advancing clinical development for gene-editing therapeutics, focusing on early-stage studies. Collaborate with cross-functional teams to design and execute global trials, ensuring...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's dedicated to enhancing patient care through effective clinical operations management. Lead staff, optimize workflows, and ensure high-quality service delivery while collaborating wi...

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Transform healthcare delivery by leading clinical operations, enhancing workflow efficiency, and driving financial success. Collaborate with senior leadership to ensure high-quality patient care and o...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$137K - $215K *

Engage with cross-functional teams to lead complex operational initiatives, translating strategic priorities into actionable plans. Drive governance, risk management, and performance monitoring to enh...

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's redefining strategic planning in healthcare. Collaborate with experts to develop innovative, multichannel strategies, driving insights and brand growth while leading diverse project...

Chicago, ILRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Optimize your career by leading strategic planning initiatives, synthesizing insights, and collaborating with cross-functional teams to drive innovative solutions in the healthcare and pharma sectors...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock your potential by leading clinical reimbursement and compliance across a multi-site skilled nursing portfolio. Collaborate closely with clinical teams to optimize documentation, reimbursement s...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Drive operational excellence in physician services by leading recruitment, onboarding, and strategic initiatives. Collaborate with clinical leaders to enhance performance and support decision-making t...

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$125K - $150K *

Join a team that's committed to ensuring quality excellence in cell therapy. Oversee integrated project plans, coordinate efforts across departments, and lead initiatives to enhance compliance and ope...

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.