Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

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$210K - $250K *

Shape the future of patient access by leading integrated strategies that enhance customer engagement and optimize portfolio performance across diverse healthcare channels, driving sustainable growth a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Lead the charge in strategic pre-award contracting, driving compliance and operational excellence. Oversee a high-performing team while collaborating across functions to enhance efficiency and support...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$113K - $188K *

Unlock potential by leading product strategy and management for diverse lines, ensuring customer needs drive innovation while aligning with corporate goals. Collaborate with cross-functional teams to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Champion growth by leading national accounts, driving strategy, and enhancing partnerships with specialty distributors and GPOs. Leverage expertise to ensure product availability and exceed corporate...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $155K *

Join a team that's redefining energy solutions by designing innovative fluid and power systems. As a Process Engineer, you'll drive the development and optimization of cutting-edge technologies in a f...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$190K - $200K *

Transform the future of work by driving AI-driven automation solutions. Engage with C-suite and technical stakeholders to showcase tailored integrations, enhance productivity, and build strategic rela...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$145K - $190K *

Join a team dedicated to advancing oncology clinical trials. In this role, you’ll manage global studies, oversee vendors, collaborate with multi-disciplinary teams, and ensure compliance with regulato...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $132K *

Champion the design of agent-ready workflows by translating complex business processes into clear requirements. Collaborate with product teams to enhance AI capabilities and ensure seamless human-agen...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $95K *

Unlock potential by designing innovative digital experiences that inspire and engage. Collaborate with teams to create user-centered solutions, leveraging research and creativity to tackle complex cha...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Lead the charge in enhancing organizational security by developing security frameworks, assessing controls, and collaborating with technical teams to create a resilient security architecture for moder...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$125K - $142K *

Unlock potential by leading clinical trial monitoring efforts, ensuring compliance and data integrity while collaborating with study teams. Your expertise will enhance patient safety and contribute to...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$97K - $132K *

Shape impactful educational proposals by leading RFP responses and submissions. Collaborate across teams to craft persuasive narratives and ensure compliance, driving state approvals and district awar...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$225K - $281K *

Lead detection and response strategy, building systems and automations to enhance security. Collaborate with teams to set standards, mentor engineers, and manage complex incidents, ensuring effective...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Join a team that's redefining healthcare recruiting by building and scaling a high-impact Direct Employer business through innovative sales strategies and cutting-edge technology, driving growth direc...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Staffing

$143K - $193K *

Transform clinical operations by leading regional study delivery, ensuring quality and compliance while managing timelines and budgets. Collaborate with cross-functional teams to drive study success a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion enterprise data architecture by establishing standards and a unified data catalog. Collaborate across teams to define metrics and ensure data governance, driving alignment and clarity in a ha...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Accelerate your career by leading a dynamic sales team to drive IT security solutions. Collaborate with clients and partners to enhance sales strategies, mentor talent, and achieve regional objectives...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$74K - $85K *

Grow your career with a supportive nursing team dedicated to quality care, offering flexible scheduling and competitive wages. Join us in enhancing residents’ lives through expert nursing practices an...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$160K - $190K *

Transform ambiguity into action by driving strategic initiatives across functions. Collaborate with executives to architect programs that enhance operational efficiency and deliver measurable business...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Champion the promotion of oncology products, building strong relationships with healthcare professionals to enhance patient access and drive brand value in a competitive market. Lead strategic initiat...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$220K - $250K *

Lead enterprise security operations and resilience, driving cyber risk strategy and innovation. Collaborate cross-functionally to embed security principles, modernize defenses, and build high-performi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Champion efficiency in the revenue cycle as you lead a dedicated billing team. Drive performance improvements, oversee compliance, and identify revenue opportunities while cultivating a culture of exc...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $185K *

Join a team that's transforming customer experiences through innovative technical solutions. As a Solutions Architect, you'll bridge business needs with technology, guiding clients from discovery to d...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Shape the future of clinical documentation integrity by leading audits and compliance initiatives across facilities. Collaborate with healthcare teams to enhance operational efficiency and ensure adhe...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.