Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$80K - $95K *
Join a team that's dedicated to enhancing contract management and customer experience. Leverage your expertise in contract administration and customer service to streamline processes and ensure compli...
1 week ago
Registered Nurse (RN) | Postpartum - GYN
$67K - $100K *
Empower patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to support patients' physical and emotional needs in a dynamic clinica...
3 weeks ago
Product Marketing Manager (Chorus)
$110K - $130K *
Shape the market presence of Chorus by owning positioning, messaging, and launch governance. Collaborate with cross-functional teams to craft strategies that enhance product perception and drive insig...
4 weeks ago
Principal, Cloud Solutions Architect
$208K - $235K *
Join a dynamic team to architect scalable cloud solutions, ensuring high engineering standards while collaborating with cross-functional stakeholders to drive innovation and governance in a fast-paced...
4 weeks ago
Associate Director, Field Execution Lead
$152K - $283K *
Deliver impactful field execution by bridging strategy and operations, ensuring initiatives achieve success through proactive risk management and collaboration across teams, all while enhancing accoun...
Reposted 3 weeks ago
Associate Director, Early Patient Engagement & Professional Societies
$145K - $195K *
Unlock patient engagement strategies by integrating insights into drug development. Collaborate with diverse teams to generate evidence, engage with professional societies, and lead initiatives that p...
1 month ago
$142K - $195K *
Unlock potential by designing secure, enterprise-scale solutions that protect critical data and systems. Collaborate with stakeholders to assess threats, innovate security architecture, and enhance en...
Reposted 4 weeks ago
Regulatory Promotional Review Specialist
$80K - $95K *
Optimize the promotional review process by coordinating cross-functional workflows, ensuring compliance, and facilitating timely approvals of marketing materials. Collaborate with internal and externa...
Yesterday
$100K - $120K *
Shape user experiences by designing intuitive UI for Playground and Console. Collaborate with senior designers on impactful feature work, enhancing product impressions while gaining fluency in our des...
3 weeks ago
Senior Principal Solutions Architect (Federal Civilian Growth)
$200K - $250K *
Join us in shaping technical strategies and growth initiatives for federal opportunities. Collaborate across teams to develop compelling solutions that drive success in complex pursuits, ensuring alig...
Reposted 2 days ago
$195K - $215K *
Lead the charge in brand strategy, inspiring teams and fostering innovative solutions in a dynamic healthcare advertising environment, focused on advancing compelling communications and effective clie...
Reposted 1 week ago
$92K - $115K *
Unlock potential by leading requirements documentation for software projects. Collaborate with stakeholders and technical teams to ensure successful delivery throughout the project lifecycle, while su...
1 week ago
Director, Business Improvement
$150K - $180K *
Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...
1 week ago
Account Specialist (Norwich, CT)
$160K - $192K *
Drive commercial success by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and enhance patient access to innovative th...
1 week ago
Senior Technical Account Manager
$110K - $130K *
Join a team that's dedicated to enhancing customer success through expert guidance in Privilege Access Management. Leverage your technical skills to support enterprise clients, ensuring seamless deplo...
3 weeks ago
$140K - $170K *
Shape the future of healthcare market strategies by analyzing trends, defining growth initiatives, and collaborating cross-functionally to drive innovation in life science and medical services. Lead m...
2 days ago
Lead Application Support Analyst - Health Plan
$67K - $108K *
Join a team that's dedicated to enhancing healthcare through innovative technology solutions. Lead projects, collaborate with stakeholders, and ensure optimal application use while mentoring team memb...
Reposted 2 days ago
$90K - $110K *
Transform Medicaid programs by managing initiatives, coordinating stakeholders, and driving quality improvements. Leverage your expertise to implement policies and enhance operational efficiency in a...
2 weeks ago
Senior Oncology Account Manager, Atlanta North
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...
1 week ago
$105K - $115K *
Optimize security measures by leading technical solutions to mitigate information risks. Ensure compliance with corporate policies and oversee incident response, safeguarding all computing platforms a...
3 weeks ago
Regional Director- Bar Review REMOTE
$90K - $95K *
Transform engagement in legal education by managing relationships, driving program success, and supporting bar exam strategies across multiple states. Collaborate with schools and students to enhance...
Reposted 6 days ago
Senior Oncology Account Manager, Pittsburgh
$150K - $230K *
Empower oncology practices by driving product adoption and building relationships with key stakeholders. Lead strategic initiatives to enhance patient access and optimize territory management while ex...
1 week ago
Category Growth Manager, Women's Hormones
$130K - $150K *
Drive growth and strategy for key telehealth categories by leveraging market insights, customer feedback, and cross-functional collaboration to enhance performance and deliver exceptional customer exp...
6 days ago
Physical Medicine and Rehabilitation Medical Director
$206K - $413K *
Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...
Reposted 5 days ago
Senior Financial Analyst (Revenue FP&A)
$100K - $120K *
Lead the charge in enhancing revenue forecasting and planning, partnering with Sales and Marketing to deliver actionable financial insights that drive growth and resource allocation across diverse rev...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.