Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Anesthesiologist Jobs in South Dakota

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$190K - $220K *

Champion impactful scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $210K *

Elevate creative excellence by leading a multidisciplinary team, setting vision and quality standards, and driving impactful brand strategies across diverse channels in a dynamic healthcare environmen...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$125K - $150K *

Join a cutting-edge team as a Senior Recruiter, responsible for sourcing and hiring top-tier quantitative researchers and data scientists to fuel innovative AI-driven investment strategies, enhancing...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $110K *

Unlock growth by owning the TPA/PEO sales strategy, managing complex accounts, and driving revenue across diverse deal sizes. Collaborate with cross-functional teams to deliver tailored solutions and...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $125K *

Transform complex commercial casualty claims management by leveraging your expertise in construction-related exposures and litigation. Collaborate with a dedicated team to deliver exceptional outcomes...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $192K *

Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and enhance patient access to innovativ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $122K *

Take ownership of financial planning and analysis for G&A expenses, driving insights and reporting for senior leadership. Collaborate with teams to enhance budgeting, forecasting, and variance analysi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a team that's shaping federal policy and advocacy. As a Government Affairs Manager, you'll engage with Congress and the Executive Branch, driving strategic initiatives across key domestic issues...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$115K - $130K *

Unlock potential by driving data analysis and interpreting clinical trial results. Collaborate with stakeholders, ensure statistical integrity, and contribute to innovative methodologies in biostatist...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$73K - $120K *

Drive the success of inpatient Payment Integrity programs by overseeing audits, ensuring compliance, and enhancing quality across teams and vendors. Collaborate with stakeholders to optimize processes...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $200K *

Lead client engagements by leveraging tax expertise to drive revenue growth, manage complex planning discussions, and enhance client relationships while ensuring strategic alignment across teams for o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$73K - $91K *

Partner with us to enhance operational efficiency and effectiveness through process analysis, continuous improvement, and expert training in LEAN methodologies, fostering collaboration and problem-sol...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$111K - $167K *

Join a dynamic team as a strategic analytics partner, driving insights and performance improvements across revenue cycle operations. Collaborate with leaders to define KPIs, analyze data, and create i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$108K - $130K *

Unlock your potential by leading customer projects, ensuring seamless communication, and driving success in healthcare solutions. Collaborate with diverse teams to enhance client satisfaction and oper...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Shape the future of oncology by driving product success and building strong relationships with healthcare professionals. Lead initiatives that enhance patient access and deliver innovative solutions i...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $165K *

Build and manage clinical stewardship operations, driving client success through effective program implementation and cross-functional collaboration. Leverage clinical expertise to enhance client rela...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $185K *

Innovate global medical strategies for the Companion Animal Pain portfolio, driving growth and customer value through scientific engagement, KOL collaboration, and effective market implementation acro...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Shape the future of talent acquisition by driving full life cycle recruitment for financial advisors. Collaborate with leadership and engage candidates to build a diverse talent pipeline while trackin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$250K - $300K *

Unlock your potential as a Diagnostic Radiologist, joining a respected practice with modern technology and a supportive team. Enjoy a balanced lifestyle while delivering exceptional patient care in a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Explore opportunities to drive oncology product success by building strong relationships with healthcare professionals, managing territory resources, and delivering impactful solutions that enhance pa...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead the charge in building strategic partnerships that drive revenue and growth. Collaborate across teams to identify opportunities, negotiate agreements, and create impactful integrations that enhan...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Transform healthcare data solutions by designing scalable architectures, optimizing data pipelines, and ensuring compliance with regulations. Collaborate with cross-functional teams to deliver high-qu...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $192K *

Accelerate commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to enhance patient access and support innovative therapies in a dyn...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$211K - $281K *

Champion regulatory excellence by leading U.S. FDA engagement and strategy for product development, ensuring timely approvals and compliance while driving cross-functional collaboration and organizati...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.