Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Product Manager, National Center for Clinical Trials (NCCT)
$122K - $183K *
Transform how we operate by leading technology-driven initiatives that enhance business capabilities. Collaborate with cross-functional teams to define product strategies and drive measurable outcomes...
4 days ago
Director of Client Experience, Lab Network
$125K - $160K *
Drive client success in our lab network by managing relationships, ensuring renewals, and identifying growth opportunities. Collaborate across teams to enhance processes and improve client experiences...
2 weeks ago
Director Search Strategy & Performance Marketing
$135K - $160K *
Pioneer in search strategy, driving optimization across paid, organic, and AI channels. This role collaborates with cross-functional teams to enhance visibility, engagement, and customer acquisition t...
Reposted 2 weeks ago
Director, Corporate Partnership Management - Remote
$110K - $115K *
Unlock potential by leading strategic enterprise partnerships, orchestrating cross-functional initiatives, and driving growth for complex, multi-million dollar accounts. Foster executive engagement an...
Today
Director, Corporate Partnership Management - Remote
$110K - $115K *
Accelerate progress at the forefront of enterprise partnerships, driving strategic alignment and growth for complex, seven-figure accounts. Lead cross-functional teams to enhance partner retention and...
Today
Director, Corporate Partnership Management - Remote
$110K - $115K *
Unlock your potential by leading strategic enterprise partnerships, driving growth, and fostering executive engagement. Collaborate across teams to enhance multi-layered initiatives and ensure alignme...
Yesterday
Director, Technical Products and Operations
$200K - $235K *
Drive product excellence by owning the lifecycle and security of high-performance client SaaS platforms hosted on AWS. Lead a dedicated team to optimize operations, ensure compliance, and deliver seam...
Reposted 2 weeks ago
Clinical Development Director, Early Development Oncology
$274K - $371K *
Develop and lead early phase clinical strategies for oncology candidates, ensuring design and execution of clinical trials. Collaborate with internal teams and external experts to drive innovative dru...
Reposted 2 weeks ago
Sr. Director of Web and Digital Strategy
$135K - $160K *
Lead the charge in shaping and executing enterprise digital strategy, overseeing web platforms and social media while aligning business goals with audience needs to enhance brand presence and performa...
3 weeks ago
Executive Director, Financial Planning & Commercial Growth
$175K - $210K *
Join a team that's shaping the future of innovation in cancer research by leading financial planning and commercialization efforts to support strategic growth and decision-making across an impactful o...
Reposted 2 weeks ago
Senior Business Development Representative, Remote
$90K - $120K *
Accelerate progress at driving revenue through strategic pipeline development and multi-touch outreach. Collaborate with marketing to uncover opportunities and engage with elite engineers, ensuring a...
1 week ago
Sr. Director, Information Security
$220K - $250K *
Lead enterprise security operations and resilience, driving cyber risk strategy and innovation. Collaborate cross-functionally to embed security principles, modernize defenses, and build high-performi...
2 weeks ago
$75K - $109K *
Advance the future of Building Information Modeling by leading BIM strategies, ensuring model quality, and mentoring teams. Drive innovation through technology initiatives and enhance project delivery...
1 week ago
$62K - $112K *
Transform member engagement by proactively addressing concerns, coordinating solutions, and enhancing satisfaction. Collaborate with cross-functional teams to drive improvements and ensure a seamless...
3 weeks ago
General Manager, Mergers & Acquisitions
$170K - $205K *
Drive the integration and growth of a newly acquired business, overseeing P&L, client relationships, and operations. Collaborate with teams to ensure seamless transition and performance against revenu...
3 weeks ago
Senior Manager II, Client Insights
$88K - $125K *
Unlock potential by leveraging advanced analytics and consultative skills to drive client success in the Consumer Healthcare vitamins sector. Collaborate cross-functionally to deliver insights and fos...
Yesterday
Sr. Advisory Consultant, Data Governance
$110K - $130K *
Take ownership of data governance by facilitating alignment among stakeholders, executing metadata management, and coaching teams on sustainable stewardship practices. Drive data quality and complianc...
Reposted 4 weeks ago
$120K - $150K *
Transform the supply chain landscape by leading procurement and subcontracting efforts, ensuring compliance with federal regulations while driving efficiency and innovation in support of critical defe...
3 weeks ago
Account Executive, Risk Management
$100K - $120K *
Unlock client success by managing complex Risk Management accounts, coordinating teams, and driving service delivery. Collaborate with clients to ensure expectations are met and explore opportunities...
3 weeks ago
$80K - $95K *
Drive the future of finance data analysis by ensuring accuracy and usability of financial data. Collaborate with finance and data teams to enhance reporting processes and validate data integrity for i...
1 week ago
Vice President, Head of Aviation
$180K - $230K *
Lead the aviation underwriting team, driving strategic growth and profitability while managing key accounts and fostering broker relationships. Oversee P&L, develop talent, and ensure compliance with...
4 days ago
Senior Backend Software Engineer, DX
$180K - $235K *
Lead the charge in developing robust backend applications, driving complex projects from design to launch. Collaborate across teams, mentor junior engineers, and tackle architectural challenges to enh...
2 weeks ago
Senior Dynamics Systems Analyst
$100K - $120K *
Join a dynamic team to lead a global transition to D365 F&O, enhancing finance operations through process improvements and automation. Collaborate across departments to streamline complex business pro...
Reposted 5 days ago
$85K - $105K *
Join a team that's dedicated to driving sales success by developing strong client relationships and identifying new business opportunities in a competitive environment. Leverage your skills to deliver...
4 days ago
Project Executive - Industrial
$150K - $180K *
Lead the charge in delivering large-scale industrial projects, ensuring operational excellence and client satisfaction while developing high-performing teams and driving strategic growth across missio...
4 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.