Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director, Talent - Talent Management
$110K - $120K *
Lead the charge in enhancing Talent Management programs, ensuring effective execution and continuous improvement. Oversee performance management, employee relations, and operational continuity while d...
2 weeks ago
Director, Talent - Talent Management
$110K - $120K *
Elevate talent management by executing core programs, enhancing employee experience, and driving performance initiatives. Lead cross-functional projects, ensuring accountability and operational contin...
2 weeks ago
Director, Talent - Talent Management
$110K - $120K *
Lead the execution and enhancement of Talent Management programs, ensuring effective performance management, employee relations, and operational continuity. Drive accountability and visibility across...
2 weeks ago
$187K - $234K *
Lead and inspire a team of Enterprise Solution Engineers to drive AI-enabled customer outcomes, collaborating across functions to deliver innovative strategies and solutions while mentoring talent and...
6 days ago
$206K - $257K *
Lead and mentor a dynamic team of Enterprise Solution Engineers, driving AI-enabled strategies and customer success across the US South. Collaborate with cross-functional teams to enhance product valu...
6 days ago
Product Management Senior Advisor
$113K - $188K *
Champion the development of innovative tools for customer service teams, enhancing agent efficiency and service quality. Collaborate across departments to drive product strategy, leveraging data and u...
1 week ago
Director of Demand Generation & Integrated Marketing
$100K - $110K *
Drive integrated demand-generation programs that engage priority audiences and convert interest into action. Collaborate across teams to optimize campaigns, enhance performance, and contribute to meas...
3 days ago
Sr. Customer Relationship Manager
$85K - $122K *
Empower customer experience by leading strategic initiatives and enhancing service delivery. Manage key accounts, drive process improvements, and mentor team members to ensure exceptional customer sat...
Yesterday
Director of Strategic Accounts (U.S. Mid-Atlantic Education)
$139K - $213K *
Join a team that's driving innovation in education technology by generating strategic opportunities and delivering tailored solutions to key decision-makers in the Mid-Atlantic region, ensuring except...
Yesterday
$75K - $90K *
Unlock new business opportunities by developing strategic marketing and sales plans. Collaborate with executives to secure and grow employer accounts, driving revenue growth and expanding market share...
6 days ago
$100K - $120K *
Join a dynamic team to drive sales growth in the beauty sector, identifying new opportunities and fostering relationships with key retailers. Collaborate across departments to shape strategies that am...
Reposted 4 weeks ago
Senior Analyst, ALM & Treasury
$88K - $141K *
Empower financial strategies by analyzing interest rate and liquidity risks. Collaborate with stakeholders to enhance capital planning and reporting processes while ensuring compliance with regulation...
1 week ago
Senior Director, Oncology Communications
$166K - $244K *
Lead the Oncology narrative and media strategy, driving impactful communications across channels. Collaborate with cross-functional teams to enhance brand presence and storytelling, ensuring alignment...
Today
Director of Property Accounting
$140K - $165K *
Shape the future of property accounting by leading a dynamic team, ensuring timely financial reporting, and driving innovative processes that enhance client trust and operational efficiency across mul...
1 week ago
Associate Director, Marketing, Lung Patient
$186K - $233K *
Shape impactful marketing strategies for lung cancer programs, collaborating with cross-functional teams to drive patient engagement and launch readiness. Lead initiatives that align with brand goals...
1 week ago
Regional Sales Director - Birmingham
$180K - $215K *
Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Collaborate cross-functionally to achieve strategic goals in a fast-pace...
1 week ago
Senior Director, Business Management & Execution Lead
$170K - $200K *
Champion operational excellence by leading business unit strategies, enhancing performance management, and driving cross-functional collaboration to achieve enterprise goals and scalable solutions...
Yesterday
Customer Growth & Success Director - Cancer Registry
$135K - $165K *
Drive customer success in Cancer Registry by building relationships, enhancing retention, and translating insights into actionable solutions. Collaborate across teams to improve outcomes and shape bus...
5 days ago
Sr. Manager Aetna Account Management
$82K - $182K *
Drive customer success by managing relationships and articulating Aetna's technology value across diverse markets. Collaborate with teams to enhance client engagement and satisfaction through innovati...
Reposted 1 week ago
$106K - $177K *
Unlock potential by leading cross-functional teams to shape product strategy, drive growth, and enhance customer value through data-driven insights and innovative solutions across the full product lif...
3 weeks ago
$80K - $95K *
Drive client success by managing a portfolio of accounts, optimizing Meta campaigns, and fostering strong relationships. Lead strategy discussions, analyze performance data, and ensure client satisfac...
6 days ago
Key Account Manager, Global Rare Diseases - Central
$165K - $198K *
Join a team that's dedicated to transforming rare disease treatment through strategic account management and collaboration. Drive sales performance while educating healthcare professionals and ensurin...
4 days ago
$200K - $225K *
Transform healthcare data into actionable insights by leading actuarial strategy and health economic analyses. Collaborate with cross-functional teams to enhance value propositions and drive commercia...
Today
$135K - $150K *
Elevate your career by leading product operations, enhancing processes, and driving AI adoption. Collaborate with cross-functional teams to optimize product delivery and analytics, ensuring seamless c...
1 week ago
Senior Manager - Dazodalibep HCP Launch Marketing
$149K - $202K *
Transform the HCP launch landscape by leading innovative marketing initiatives for a groundbreaking treatment in Sjögren's disease. Collaborate cross-functionally to engage healthcare professionals an...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.