Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$84K - $126K *
Join a team that's driving growth in the cardiovascular ASC market by developing strategic partnerships and executing innovative market strategies across the U.S. Collaborate with diverse stakeholders...
4 days ago
$113K - $188K *
Elevate your career by leading strategic sourcing initiatives, driving supplier negotiations, and developing comprehensive category strategies to maximize member value and enhance operational efficien...
Yesterday
$113K - $188K *
Reimagine your career with a strategic sourcing leader role, driving negotiation strategies and supplier engagement to enhance service line value. Collaborate with cross-functional teams to optimize s...
Yesterday
$113K - $188K *
Transform your career by leading strategic sourcing initiatives, driving supplier negotiations, and enhancing value for service lines. Collaborate with cross-functional teams to develop innovative str...
Yesterday
Operations Director, Biomarker Programs
$175K - $200K *
Lead the charge in optimizing biomarker program operations, ensuring seamless sample processing from collection to storage. Collaborate across teams to uphold quality and compliance while driving grow...
2 weeks ago
$80K - $95K *
Join a team that's driving financial excellence by managing revenue accounting activities, ensuring compliance with ASC 606, and leveraging advanced analytics to enhance reporting and operational effi...
2 weeks ago
$79K - $109K *
Transform financial operations by owning monthly close processes, ensuring accurate COGS and accruals. Collaborate with leadership to drive data-driven decisions in a dynamic, growth-stage tech enviro...
1 week ago
$229K - $310K *
Drive project management and business development to enhance operational efficiency in life sciences R&D, while leading diverse teams and ensuring profitability through strategic customer engagement a...
Reposted 1 week ago
$85K - $100K *
Drive financial excellence by owning month-end close, reconciliations, and management reporting. Collaborate with leadership to enhance processes and ERP systems, ensuring accuracy and compliance as t...
2 weeks ago
Director, Financial Services Customer Partner - Incentive
$159K - $286K *
Architect strategic account relationships to drive growth and profitability. Leverage deep connections with C-suite executives to deliver tailored solutions and maximize renewals, ensuring customer sa...
1 week ago
Senior Director, Corporate Relations- St Louis, MO
$115K - $150K *
Lead corporate partnerships and account management to drive revenue growth, targeting Fortune 1000 companies. Cultivate executive relationships and manage a team to secure multi-million dollar partner...
2 weeks ago
$114K - $135K *
Transform event experiences by leading strategy and execution for high-impact trade shows and corporate events. Collaborate cross-functionally to drive brand awareness and measurable business impact i...
Reposted 2 weeks ago
$175K *
Optimize revenue cycle management by leading a dynamic team to enhance processes, drive automation, and ensure compliance in a fast-paced telehealth environment. Collaborate with cross-functional team...
Reposted today
Sr. / Principal Medical Writer (Regulatory focus) - Sponsor-dedicated; NA/CAN/UK
$80K - $175K *
Champion the creation of high-quality regulatory documents, managing writing tasks and leading reviews. Collaborate across teams to ensure clarity and compliance, mentoring junior writers while delive...
Reposted 2 weeks ago
Sr. / Principal Medical Writer (Regulatory focus) - Sponsor-dedicated; NA/CAN/UK
$110K - $130K *
Advance your career by leading medical writing projects in a regulatory environment. Collaborate with cross-functional teams to produce high-quality documents, ensuring compliance with industry standa...
1 week ago
Product Manager, New Content Initiatives and Analysis
$140K - $175K *
Transform investment research by evaluating and integrating diverse datasets, enhancing AI-driven workflows, and driving strategic content initiatives to elevate platform value and user experience...
1 week ago
Principal IT Analyst - Veeva RIM
$121K - $161K *
Transform your career by leading the design and implementation of Veeva Vault RIM, ensuring optimal performance and compliance while collaborating with cross-functional teams to enhance user experienc...
4 weeks ago
Enterprise Account Executive, Florida
$290K - $305K *
Pioneer enterprise sales in Florida, driving value-based solutions for large organizations. Collaborate with cross-functional teams to exceed targets, utilizing strategic partnerships to enhance growt...
Reposted 2 weeks ago
$110K - $130K *
Join a team that's redefining DME resupply operations by leading a global, remote call center. Drive revenue growth, optimize performance, and ensure compliance while managing a diverse workforce to e...
6 days ago
$180K - $190K *
Empower our team to drive innovation by developing crucial AI tools that enhance operational efficiency. Oversee governance, training, and metrics to ensure impactful adoption across departments while...
Reposted 4 days ago
$240K - $330K *
Unlock potential by leading a global enablement team to develop and implement a comprehensive strategy that enhances sales effectiveness and drives revenue growth across all customer-facing roles...
3 weeks ago
Sr. Revenue Operations Director, Digital Commerce
$135K - $160K *
Elevate your career by driving new business initiatives and enhancing operational efficiency. Collaborate with cross-functional teams to resolve issues and optimize processes, ensuring seamless execut...
Today
Claims Technical Director - General Liability
$140K - $160K *
Join a team that's dedicated to managing complex general liability claims, focusing on Construction and specialty lines. Drive strategic claim resolutions, ensure compliance, and enhance customer sati...
4 days ago
$190K - $250K *
Lead strategic partnerships with cloud providers to drive co-sell initiatives, enhance pipeline generation, and foster deep relationships with key stakeholders, ensuring alignment between internal sal...
5 days ago
$190K - $250K *
Drive growth by managing strategic cloud partnerships, aligning sales strategies, and executing co-sell initiatives to enhance pipeline and revenue. Collaborate with internal teams and cloud partners...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.