Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$140K - $180K *

Elevate customer insights by translating data into actionable product capabilities. Collaborate with cross-functional teams to prioritize initiatives, enhance marketing performance, and leverage AI fo...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$168K - $240K *

Lead the charge in optimizing business operations through innovative solutions, driving efficiency and productivity while fostering cross-functional collaboration and data-driven decision-making to en...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Engineer robust security solutions by assessing web applications and APIs. Leverage your expertise in OWASP and SANS frameworks to identify vulnerabilities, conduct thorough testing, and enhance secur...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Unlock potential by partnering with ABA practice owners to enhance operations, drive growth, and improve performance. Collaborate closely with providers to navigate challenges and implement strategic...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $105K *

Join us to analyze and adjudicate complex workers compensation claims, delivering innovative solutions in a dynamic environment. Collaborate with clients across industries while enjoying professional...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Drive product strategy and execution for a critical portfolio area, leading cross-functional teams to transform user insights into impactful software solutions while mentoring others and shaping platf...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Lead the charge in shaping product marketing strategies that drive adoption and pipeline. Collaborate with cross-functional teams to craft compelling narratives and ensure our differentiated value res...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$77K - $126K *

Lead the charge in managing complex construction projects, ensuring financial success and customer satisfaction while collaborating with stakeholders and subcontractors to deliver exceptional results...

2 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$130K - $140K *

Elevate your career by joining a dynamic team to design and implement innovative cloud solutions in a multi-cloud environment, ensuring scalability, security, and alignment with business objectives wh...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$162K - $203K *

Champion scientific engagement by building relationships with key opinion leaders in Urology and Women's Health. Leverage expertise to support medical strategies and enhance product knowledge across t...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Elevate employee experiences by designing and implementing HR solutions. Lead technical projects, optimize integrations with Microsoft 365, and mentor developers to enhance ServiceNow capabilities and...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Champion the growth of our commercial engine by leading business development efforts, forging strategic partnerships, and driving revenue as quantum computing transitions to enterprise applications. C...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $185K *

Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$115K - $140K *

Drive operational excellence in commercial readiness and support cross-functional teams to ensure effective execution of launch strategies and operational priorities in a dynamic biotech environment...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$225K - $275K *

Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a team that's redefining product marketing by leading impactful go-to-market strategies, enabling sales teams, and shaping customer insights to drive success in a fast-paced B2B SaaS environment...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$132K - $207K *

Elevate your career by driving growth in the mortgage industry, partnering with top lenders to enhance FICO's analytics solutions. Lead strategic initiatives, foster client relationships, and deliver...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$200K - $225K *

Transform marketing strategies to drive growth and engagement across public and private sectors. Lead integrated marketing efforts, brand positioning, and customer marketing services while leveraging...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$157K - $256K *

Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $182K *

Accelerate growth by driving new software sales, building client relationships, and tailoring solutions to meet unique business needs. Collaborate with cross-functional teams to ensure a seamless cust...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$85K - $105K *

Optimize regulatory compliance processes for a multi-state transportation network. Collaborate cross-functionally to ensure operational readiness and manage ongoing compliance across diverse markets...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$168K - $210K *

Transform pricing strategies by leading cross-functional teams to enhance decision-making and model deployment. Drive the evolution of pricing platforms, integrating advanced AI to streamline workflow...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$210K *

Elevate patient care by delivering high-quality telehealth services across South Dakota. Join a compassionate team of board-certified physicians managing diverse clinical cases through innovative virt...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $150K *

Elevate your career by driving enterprise sales for innovative solutions. Engage with multinational accounts, build strategic relationships, and lead complex negotiations to unlock growth opportunitie...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Shape strategic sales initiatives targeting Fortune 2000 accounts. Drive complex sales cycles, engage with C-suite leaders, and leverage AI solutions to meet revenue goals while building a robust pipe...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.