Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$140K - $180K *
Elevate customer insights by translating data into actionable product capabilities. Collaborate with cross-functional teams to prioritize initiatives, enhance marketing performance, and leverage AI fo...
2 days ago
Senior Director Business Operations
$168K - $240K *
Lead the charge in optimizing business operations through innovative solutions, driving efficiency and productivity while fostering cross-functional collaboration and data-driven decision-making to en...
2 days ago
Application Penetration Tester
$110K - $130K *
Engineer robust security solutions by assessing web applications and APIs. Leverage your expertise in OWASP and SANS frameworks to identify vulnerabilities, conduct thorough testing, and enhance secur...
2 days ago
Strategic ABA Practice Partner
$100K - $120K *
Unlock potential by partnering with ABA practice owners to enhance operations, drive growth, and improve performance. Collaborate closely with providers to navigate challenges and implement strategic...
2 days ago
Workers Compensation Claims Examiner | Riverside, CA
$85K - $105K *
Join us to analyze and adjudicate complex workers compensation claims, delivering innovative solutions in a dynamic environment. Collaborate with clients across industries while enjoying professional...
2 days ago
Principal Product Manager, GRC
$150K - $180K *
Drive product strategy and execution for a critical portfolio area, leading cross-functional teams to transform user insights into impactful software solutions while mentoring others and shaping platf...
2 days ago
$110K - $130K *
Lead the charge in shaping product marketing strategies that drive adoption and pipeline. Collaborate with cross-functional teams to craft compelling narratives and ensure our differentiated value res...
2 days ago
$77K - $126K *
Lead the charge in managing complex construction projects, ensuring financial success and customer satisfaction while collaborating with stakeholders and subcontractors to deliver exceptional results...
2 days ago
$130K - $140K *
Elevate your career by joining a dynamic team to design and implement innovative cloud solutions in a multi-cloud environment, ensuring scalability, security, and alignment with business objectives wh...
2 days ago
Medical Science Liaison - Senior Medical Liaison - Mid Atlantic Region
$162K - $203K *
Champion scientific engagement by building relationships with key opinion leaders in Urology and Women's Health. Leverage expertise to support medical strategies and enhance product knowledge across t...
2 days ago
ServiceNow Mid-Level Developer
$130K - $150K *
Elevate employee experiences by designing and implementing HR solutions. Lead technical projects, optimize integrations with Microsoft 365, and mentor developers to enhance ServiceNow capabilities and...
2 days ago
$150K - $180K *
Champion the growth of our commercial engine by leading business development efforts, forging strategic partnerships, and driving revenue as quantum computing transitions to enterprise applications. C...
2 days ago
Associate Director, Clinical Supply Chain (Remote)
$150K - $185K *
Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...
Reposted 2 days ago
Commercial Operations Manager (Remote)
$115K - $140K *
Drive operational excellence in commercial readiness and support cross-functional teams to ensure effective execution of launch strategies and operational priorities in a dynamic biotech environment...
Reposted 2 days ago
Senior Director, Quality Assurance (Remote)
$225K - $275K *
Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...
Reposted 2 days ago
$95K - $115K *
Join a team that's redefining product marketing by leading impactful go-to-market strategies, enabling sales teams, and shaping customer insights to drive success in a fast-paced B2B SaaS environment...
2 days ago
Sr Strategic Account Manager (Director)-IMB
$132K - $207K *
Elevate your career by driving growth in the mortgage industry, partnering with top lenders to enhance FICO's analytics solutions. Lead strategic initiatives, foster client relationships, and deliver...
2 days ago
$200K - $225K *
Transform marketing strategies to drive growth and engagement across public and private sectors. Lead integrated marketing efforts, brand positioning, and customer marketing services while leveraging...
2 days ago
Associate Director, US Pricing, Contracting and Channel Strategy
$157K - $256K *
Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...
2 days ago
Account Executive, Maestro PMS
$120K - $182K *
Accelerate growth by driving new software sales, building client relationships, and tailoring solutions to meet unique business needs. Collaborate with cross-functional teams to ensure a seamless cust...
2 days ago
$85K - $105K *
Optimize regulatory compliance processes for a multi-state transportation network. Collaborate cross-functionally to ensure operational readiness and manage ongoing compliance across diverse markets...
2 days ago
Staff Product Manager, Pricing
$168K - $210K *
Transform pricing strategies by leading cross-functional teams to enhance decision-making and model deployment. Drive the evolution of pricing platforms, integrating advanced AI to streamline workflow...
2 days ago
Physician, Family Medicine - Telemedicine Opportunity - DrHouse
$210K *
Elevate patient care by delivering high-quality telehealth services across South Dakota. Join a compassionate team of board-certified physicians managing diverse clinical cases through innovative virt...
2 days ago
$120K - $150K *
Elevate your career by driving enterprise sales for innovative solutions. Engage with multinational accounts, build strategic relationships, and lead complex negotiations to unlock growth opportunitie...
2 days ago
$150K - $180K *
Shape strategic sales initiatives targeting Fortune 2000 accounts. Drive complex sales cycles, engage with C-suite leaders, and leverage AI solutions to meet revenue goals while building a robust pipe...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.