Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Payroll & Reporting Specialist
$70K - $93K *
Lead the charge in executing complex multi-state payroll processes, ensuring accuracy and compliance while collaborating cross-functionally. Drive system enhancements and maintain operational integrit...
2 days ago
$90K - $110K *
Join our new Data Engineering team to lead business intelligence initiatives, build trusted data models in Snowflake, and deliver impactful reports in Power BI. Collaborate with stakeholders to enhanc...
2 days ago
$100K - $120K *
Champion endpoint strategy and governance, leading a specialized team to deliver secure, scalable services across diverse devices. Collaborate with IT and business leaders to drive automation, operati...
2 days ago
Corporate Sales Engineer, Customer Sales (Remote)
$75K - $115K *
Innovate in cybersecurity as you drive technical conversations and deliver tailored solutions. Collaborate with sales teams to enhance customer relationships and showcase the unique value of next-gen...
2 days ago
Specialist, Cloud Security (Remote)
$85K - $128K *
Unlock potential by driving cloud security sales initiatives, collaborating with teams, establishing partnerships with key personas, and engaging customers to integrate innovative security solutions i...
Reposted 2 days ago
Manager, Platform Services Project Management (Remote)
$140K - $195K *
Transform project delivery by leading a team of Project Managers to ensure timely, budget-conscious deployment of customer projects while enhancing processes and driving efficiency across cross-functi...
2 days ago
$95K - $115K *
Optimize cloud data infrastructure by managing Snowflake systems, designing data pipelines, and collaborating with teams to enhance data accessibility and performance. Ensure reliability and scalabili...
Reposted 2 days ago
Field Application Engineer - Mission Critical / Raceway
$120K - $160K *
Elevate your career by serving as a technical leader for steel and PVC raceway products, driving specifications and supporting installations in commercial and industrial markets. Collaborate with engi...
2 days ago
Automation Engineer (Cisco CNC Upgrade)
$77K - $118K *
Transform network operations by designing and implementing automation solutions that enhance reliability and efficiency across multi-vendor infrastructures, utilizing advanced technologies like Python...
Reposted 2 days ago
$77K - $118K *
Drive the evolution of scalable, secure platforms by architecting solutions that enhance network intelligence and application delivery, collaborating with cross-functional teams to optimize performanc...
Reposted 2 days ago
Director, Global Transfer Pricing
$174K - $234K *
Champion the development and governance of global transfer pricing strategies, ensuring alignment with business operations and compliance across jurisdictions while leading cross-functional collaborat...
2 days ago
Senior Director, Regulatory Affairs, CMC
$204K - $274K *
Champion the U.S. Biologics Regulatory CMC team by providing strategic leadership, ensuring timely regulatory submissions, and fostering collaboration among global stakeholders to drive innovative bio...
Reposted 2 days ago
Thought Leader Liaison, US Oncology, South
$167K - $300K *
Unlock your potential by leading regional oncology thought leader engagement and advocacy strategies. Collaborate with cross-functional teams to shape brand strategy and launch planning for innovative...
2 days ago
Thought Leader Liaison, US Oncology, Northeast
$167K - $300K *
Elevate oncology marketing strategies by leading KOL engagement and advocacy initiatives. Utilize market insights to shape brand strategy and launch planning for innovative therapies, ensuring complia...
2 days ago
Thought Leader Liaison, US Oncology, Central
$167K - $300K *
Lead the charge in transforming cancer treatment through strategic KOL engagement and advocacy. Drive regional initiatives, leveraging market insights to shape brand strategy and launch planning for i...
2 days ago
Thought Leader Liaison, US Oncology, West
$167K - $300K *
Lead the charge in oncology marketing by developing KOL engagement strategies and insights for individualized therapies. Collaborate cross-functionally to drive brand strategy and launch planning, ens...
2 days ago
Senior Analyst Treasury Cash Forecasting & Analysis
$79K - $112K *
Transform cash forecasting processes by leveraging technology and analytics. Collaborate with Treasury leadership to enhance cash flow insights and automate reporting, ensuring accuracy and efficiency...
2 days ago
Assistant Director, Supervision
$127K - $171K *
Lead a dynamic team in overseeing compliance and supervision for securities and investment advisers. Drive risk mitigation strategies, enhance supervisory frameworks, and collaborate with cross-functi...
2 days ago
$137K - $185K *
Drive the execution of complex projects, ensuring alignment across global teams. Collaborate with stakeholders to manage risks, track progress, and deliver key medical strategies while fostering cross...
2 days ago
$120K - $145K *
Unlock product potential by leading the development of innovative food safety solutions. Collaborate with cross-functional teams to address complex industry challenges and drive scalable product strat...
2 days ago
$90K - $110K *
Lead a dynamic sales team to drive growth and enhance customer relationships. Foster a culture of accountability and collaboration while implementing strategic sales initiatives that support profitabi...
2 days ago
$125K - $150K *
Shape the future of marketing by leading strategy and execution in a dynamic B2B SaaS environment. Collaborate closely with leadership to drive pipeline growth and create compelling narratives that re...
2 days ago
Sr Manager, Data Process Excellence & Transformation
$115K - $192K *
Elevate operational excellence by leading process design and transformation initiatives. Drive automation, quality management, and continuous improvement to enhance client data operations and ensure s...
Reposted 2 days ago
Senior Scientist, Safety Assessment and Investigative Toxicology
$66K - $189K *
Innovate analytical strategies to enhance toxicology assessments, ensuring compliance and data integrity. Collaborate across teams to drive project success and influence decision-making through advanc...
2 days ago
Manager, Dispatch Follow Up (Cox Fleet)
$81K - $122K *
Transform fleet operations by leading a dynamic dispatch team, ensuring exceptional service delivery and operational excellence while fostering team development and customer satisfaction in a fast-pac...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.