Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$100K - $110K *
Elevate the impact of early childhood development by managing and expanding the HELP product suite. Drive customer relationships, account growth, and new business development while supporting practiti...
4 days ago
$96K - $115K *
Lead strategic hiring initiatives by partnering with senior leaders to source and secure top salaried and executive talent. Drive full-cycle recruitment, market intelligence, and candidate experience...
Reposted 4 days ago
Director, MSP Sales Acceleration
$259K - $323K *
Unlock potential by leading a global team to drive sales activation within MSP partners, enhancing service demand and ensuring partner success through strategic enablement and collaboration across reg...
4 days ago
$73K - $91K *
Lead compassionate patient care as a Registered Nurse, collaborating with interdisciplinary teams to enhance health outcomes. Thrive in a supportive environment that values teamwork, professionalism...
4 days ago
$73K - $91K *
Lead compassionate patient care as a Registered Nurse, utilizing clinical expertise to enhance health outcomes. Collaborate with interdisciplinary teams in a dynamic environment, ensuring quality and...
4 days ago
$76K - $96K *
Empower patient care by joining our dedicated nursing team, where you'll provide compassionate, quality care in a fast-paced environment. Collaborate with healthcare professionals to enhance patient o...
4 days ago
$96K - $133K *
Join a team that's dedicated to delivering high-quality projects on time and within budget. As a key player, you'll coordinate efforts across departments, ensuring effective communication and resource...
4 days ago
Data and AI Governance Specialist
$108K - $149K *
Advance the organization by establishing robust data and AI governance practices. Collaborate across teams to ensure compliance, integrity, and responsible usage of data and AI assets, supporting both...
Reposted 4 days ago
Senior Compensation Consultant
$110K - $130K *
Lead complex compensation initiatives, ensuring equitable pay programs while managing projects. Serve as a subject matter expert in various compensation areas and collaborate with teams to enhance org...
Reposted 4 days ago
Workers' Compensation Claims Specialist - Alternative Markets
$90K - $110K *
Unlock potential by joining a dynamic team as a Workers’ Compensation Claims Specialist. Leverage your expertise to investigate, resolve, and manage claims while ensuring compliance and delivering exc...
Reposted 4 days ago
Senior Product Analyst - Employer Health Solutions
$79K - $125K *
Lead the charge in enhancing Employer Health Solutions products, driving market competitiveness through collaboration, strategic analysis, and innovative development. Support regulatory compliance and...
Reposted 4 days ago
Senior Business Intelligence Analyst - Enterprise Analytics
$90K - $115K *
Lead the charge in transforming complex business needs into impactful analytic products. Collaborate with stakeholders to design, develop, and maintain reusable semantic models that enhance decision-m...
4 days ago
$180K - $220K *
Lead the global Accounting and Treasury function, driving financial systems, reporting, and IPO readiness while building a scalable team to support international growth and operational complexity...
4 days ago
$165K - $215K *
Champion the evolution of Android features, driving product impact through collaboration and innovation. Own the development process from concept to deployment, ensuring high-quality user experiences...
4 days ago
$160K - $200K *
Join us to redefine retail marketing in the cannabis industry. Lead strategy, visual merchandising, and shopper engagement initiatives to enhance brand presence and drive sales across U.S. dispensarie...
4 days ago
Finance Program Manager - Work at Home
$97K - $155K *
Empower strategic financial decisions by analyzing data trends. Contribute to budgeting, reporting, and operational improvements, ensuring compliance with financial guidelines while supporting healthc...
Reposted 4 days ago
$130K - $140K *
Shape the future of AI-driven financial advice by designing intuitive, impactful products. Collaborate closely with PMs and engineers to create solutions that enhance user experience and drive results...
4 days ago
Principal Business Intelligence Lead, System Performance
$200K - $275K *
Elevate data strategy and reporting for the System Performance Organization, transforming complex robotics data into compelling narratives for executive stakeholders while fostering team growth and al...
Reposted 4 days ago
Head of Policy and Public Affairs
$200K - $220K *
Lead strategic policy initiatives and public affairs to drive next-gen power infrastructure deployment with carbon capture. Engage stakeholders and influence regulatory frameworks to support sustainab...
4 days ago
$110K - $130K *
Join a dynamic team providing empathetic pharmacy consulting and clinical services. Oversee pharmacy operations, enhance patient experiences, and manage staff performance while ensuring compliance wit...
4 days ago
$80K - $95K *
Elevate compliance standards by coordinating and executing key program elements, advising on policies, delivering training, and managing compliance risks, ensuring an ethical culture and integrity in...
Reposted 4 days ago
$160K - $180K *
Collaborate with partners to build a robust technical foundation for channel sales. Enable engineers to independently deploy solutions, ensuring technical readiness and driving measurable success in p...
4 days ago
Sr. Engineer - Platform Data Engineer (Remote)
$140K - $215K *
Unlock potential by architecting and managing robust data infrastructure, ensuring reliability and scalability while mentoring junior engineers and enhancing platform performance in a dynamic analytic...
4 days ago
Product Manager (Records Management Systems) - Remote
$110K - $130K *
Advance public safety software solutions by driving the product vision and roadmap for Records Management Software, optimizing features and ensuring alignment with customer needs, market trends, and t...
Reposted 4 days ago
Virtual Design Construction Designer
$68K - $93K *
Unlock your potential by driving project success with design expertise and collaboration. As a key contributor, you will innovate and mentor, ensuring high standards in virtual design and construction...
Reposted 4 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.