Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Channel Sales Representative, Microsoft Teams Voice
$162K - $244K *
Join a team that's driving channel success by building strong partnerships, creating impactful business plans, and enhancing pipeline growth through strategic collaboration and support for regional pa...
3 days ago
Senior Supplier Quality Engineer
$116K - $154K *
Bring your expertise to drive supplier quality excellence, implementing quality plans, managing audits, and fostering improvements. Collaborate with engineering teams to enhance manufacturability and...
3 days ago
Associate Director Of Brand Activation & Content
$120K - $145K *
Lead the charge in defining and activating brand strategies across multiple channels, enhancing donor engagement and retention through innovative content and social communications while collaborating...
3 days ago
Sr. Principal Contract Negotiation Analyst
$106K - $160K *
Lead complex contract negotiations and drive strategic supplier relationships. Collaborate with stakeholders to assess risks, develop negotiation strategies, and enhance contracting practices while me...
3 days ago
Clinical Applications Pharmacist
$95K - $115K *
Join our team to enhance clinical systems for medication management, focusing on optimizing workflows and supporting pharmacy operations. Collaborate with stakeholders to ensure accuracy and efficienc...
3 days ago
$152K - $209K *
Champion AI security by leading the development of standards and frameworks that enable responsible AI adoption across the enterprise, ensuring compliance and risk management while fostering innovatio...
3 days ago
Technical Specialist - Embedded QT
$168K - $231K *
Unlock potential by leading the design and development of innovative software solutions for medical devices. Collaborate with cross-functional teams to ensure high-quality, secure software that enhanc...
3 days ago
SAP Functional Consultant – Finance & Logistics (FI/CO/FM/SD)
$90K - $189K *
Support Department of Defense operations by configuring SAP S/4HANA for finance and logistics. Collaborate with stakeholders to enhance enterprise systems, ensuring seamless integration and compliance...
3 days ago
$63K - $129K *
Shape your career by driving Agile execution excellence in federal HCM modernization. Lead cross-functional teams, facilitate SAFe ceremonies, and foster a continuous improvement culture within a larg...
Reposted 3 days ago
SME Software Developer - REMOTE
$114K - $252K *
Unlock potential by leading software development initiatives, ensuring system integration, and guiding teams through agile methodologies to deliver high-quality solutions that meet customer requiremen...
3 days ago
Regulatory Submissions Lead II
$110K - $130K *
Lead and execute regulatory strategies for multi-region clinical trials, ensuring compliance and timely submissions. Collaborate with project teams to manage risks and drive operational excellence thr...
3 days ago
Lead Mechanical Engineer 1 - Nuclear Plant Analysis
$118K - $180K *
Join a dynamic team enhancing nuclear power plants through advanced engineering. Leverage your expertise in thermodynamics and fluid mechanics to drive power uprate projects, mentor junior staff, and...
3 days ago
Senior Air Permitting Specialist
$100K - $152K *
Empower progress in environmental compliance by developing air permitting strategies for complex industrial projects. Collaborate with multi-disciplined teams to ensure adherence to air quality regula...
3 days ago
Structural Engineering Consultant 2 - Nuclear
$145K - $222K *
Lead a structural engineering team, guiding projects for nuclear facilities. Utilize your expertise in design and analysis while collaborating with clients and multidisciplinary teams to deliver innov...
3 days ago
Project Management Technical Director - Northern/Central California
$132K - $174K *
Shape the future of environmental consulting by leading complex projects, fostering client relationships, and driving strategic initiatives. Collaborate with multidisciplinary teams to ensure excellen...
3 days ago
$110K - $130K *
Elevate product execution by translating client needs into actionable requirements, collaborating with engineering and data science teams to deliver standardized measurement solutions across various c...
3 days ago
$89K - $113K *
Transform data integrity by assisting in the analysis and cleansing of Enterprise Business Systems. Collaborate with teams to resolve anomalies and ensure compliance with DoD standards while supportin...
3 days ago
Manager of Clinical Engagement
$115K - $130K *
Join a team that's redefining clinical engagement by leading strategic initiatives to enhance clinician pipelines, improve hiring processes, and foster partnerships across multiple regions, driving or...
3 days ago
Senior Product Marketing Manager, Risk Advisory
$125K - $150K *
Shape the future of product marketing by bridging product and go-to-market teams. Drive impactful messaging, enablement, and strategies that resonate with audiences, ensuring alignment in a fast-paced...
3 days ago
$115K - $150K *
Architect and streamline cloud network infrastructure. Support robust security and connectivity across Azure, OpenShift, and SASE platforms. Collaborate with cross-functional teams, ensuring optimal p...
Reposted 3 days ago
Workday Integrations Principal Consultant - Global AMS (Global Application Managed Services)
$106K - $159K *
Unlock potential by leading integration initiatives and providing expert guidance within a dynamic team, ensuring effective business solutions and improved service delivery for a portfolio of global c...
Reposted 3 days ago
Engineering Manager - Product Development & Vertical Brands (REMOTE)
$95K - $158K *
Join a dedicated team to lead the software development efforts for private brand growth. Empower engineers to create innovative solutions while overseeing project delivery and fostering a collaborativ...
Reposted 3 days ago
Senior Manager, Financial Planning & Analysis
$142K - $178K *
Lead the charge in strategic financial planning, driving insights and forecasts that shape growth. Collaborate with executives and teams to enhance financial models and reporting processes in a dynami...
3 days ago
$120K - $145K *
Join a dynamic finance team as you oversee financial reporting, manage reconciliations, and enhance accounting processes. Your expertise will ensure compliance with GAAP while supporting audits and op...
Reposted 3 days ago
$110K - $130K *
Engage with customers to unlock growth by developing strategic partnerships, managing account pipelines, and delivering tailored solutions that meet operational needs while representing the company at...
Reposted 3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.